Modified carbocyanine dyes and their conjugates
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United States of America Patent
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Sep 7, 2010
Grant Date -
May 11, 2006
app pub date -
Dec 20, 2005
filing date -
Sep 29, 2000
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Abstract
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
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