Biomarker isolation and use thereof to characterize physiological state

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United States of America Patent

PATENT NO 7794952
SERIAL NO

11639414

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Abstract

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The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their presence or absence to a physiological state. The biomarkers can be captured from the system, and then detected using any suitable analytical system to determine their presence or absence. In one embodiment, the invention relates to a method of detecting a polypeptide biomarker in a blood serum or plasma sample obtained from a single subject with an affinity ligand which is capable of binding to a plurality of different polypeptide biomarkers derived from the same parental molecule.

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Patent Owner(s)

Patent OwnerAddress
GEORGE MASON UNIVERSITY OF FAIRFAX VIRGINIA4400 UNIVERSITY DRIVE FAIRFAX VA 22030

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liotta, Lance Bethesda, US 42 265
Petricoin, Emanuel Gainesville, US 20 233

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