Liquid chromatography-mass spectrometry
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United States of America Patent
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Sep 21, 2010
Grant Date -
Dec 25, 2008
app pub date -
Mar 21, 2008
filing date -
Mar 23, 2007
priority date (Note) -
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Abstract
A liquid chromatography/mass spectrometry system includes a chromatographic column through which an effluent passes, wherein the effluent comprises a plurality of analytes that correspond to a plurality of chromatographic peaks and an eluent; a post-column splitter having at least two output ports through which the effluent of the column is split to at least a first portion and a second portion; a mass spectrometer configured to receive the first portion from a first of the output ports for analysis; and a tube connected to a second of the output ports configured to prevent substantial evaporation of the eluent in the second portion until undergoing mass spectrometry. The second portion has a plurality of separated analytes corresponding to at least two chromatographic peaks. A method of using the system is also disclosed.
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