Lipophilic diesters of chelating agent for inhibition of enzyme activity
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United States of America Patent
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Sep 21, 2010
Grant Date -
Jul 27, 2006
app pub date -
Mar 16, 2003
filing date -
Sep 25, 2002
priority date (Note) -
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Abstract
The present invention relates to the use of lipophilic diesters of the chelating agent 1,2-bis(2 aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) for inhibition of proteolytic activities of certain metalloproteinases and of calpain. The invention further relates to methods for preventing, treating or managing MMP-related and calpain-related diseases or disorders in mammals comprising administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of said lipophilic diesters of the chelating agent BAPTA.
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