Medical device with coating that promotes endothelial cell adherence
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United States of America Patent
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Sep 28, 2010
Grant Date -
Feb 24, 2005
app pub date -
Apr 26, 2004
filing date -
Mar 15, 2000
priority date (Note) -
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Abstract
A medical device with a coating for capturing target cells in vivo is provided. In particular, the medical device is coated with at least one layer of matrix and a layer of antibodies, antibody fragments or combinations thereof, which bind with specificity to mature or progenitor endothelial cells at various developmental stages to form an endothelial cell layer on the surface of the device. The coated medical device can be, for example, a stent or a synthetic graft and is useful in therapy of diseases such as restenosis, atherosclerosis, and thromboembolic complications.
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