In vitro generation of GABAergic neurons from pluripotent stem cells
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United States of America Patent
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Oct 26, 2010
Grant Date -
May 5, 2005
app pub date -
Aug 31, 2004
filing date -
Sep 3, 2003
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Expired
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Abstract
The present disclosure is directed to improved methods for efficiently producing neuroprogenitor cells and differentiated neural cells such as GABAergic neurons from pluripotent stem cells, for example embryonic stem cells. Using the disclosed methods, cell populations containing a high proportion of GABAergic neurons have been isolated. The neuroprogenitor cells and terminally differentiated cells of the present disclosure can be generated in large quantities, and therefore may serve as an excellent source for cell replacement therapy in neurodegenerative disorders and neuronal diseases such as stroke, ischemia, epilepsy, and Huntington's disease.
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