Methods of purifying Fc region containing proteins
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United States of America Patent
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Oct 26, 2010
Grant Date -
Mar 29, 2007
app pub date -
Jun 16, 2006
filing date -
Jun 17, 2005
priority date (Note) -
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Abstract
The present application provides methods of purifying polypeptides having a Fc region, for example, antibodies or antibody fusions, by adsorbing the polypeptides to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt buffer to remove impurities and subsequent recovery of the adsorbed polypeptides. The present application also features methods of eluting the purified polypeptide as well as the incorporation of the methods within a purification train. Kits comprising components for carrying out the methods and instructions for use are also provided.
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