Methods of identifying compounds that target tRNA splicing endonuclease and uses of said compounds as anti-fungal agents
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United States of America Patent
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Nov 9, 2010
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Mar 26, 2004
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Mar 27, 2003
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Abstract
The present invention relates to a method for screening and identifying compounds that modulate the activity of a fungal tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit or reduce the activity of a fungal tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for preventing, treating, managing and/or ameliorating a fungal infection or fungal infestation or one or more symptoms thereof.
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