Phosphorus-containing thyromimetics
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United States of America Patent
Stats
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Nov 9, 2010
Grant Date -
May 7, 2009
app pub date -
Nov 19, 2004
filing date -
Nov 19, 2003
priority date (Note) -
In Force
status (Latency Note)
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Importance

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Forward Citations
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Abstract
The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndromex and diabetes.

First Claim
Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | Total Patents |
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METABASIS THERAPEUTICS, INC. | SAN DIEGO, CA | 47 |
International Classification(s)

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- [Patents Count]
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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Boyer, Serge H | San Diego, US | 15 | 191 |
Erion, Mark D | Del Mar, US | 65 | 1396 |
Jiang, Hongjian | San Diego, US | 12 | 40 |
Cited Art Landscape
Patent Info | (Count) | # Cites | Year |
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2003/0040,535 Tetrazole compounds as thyroid receptor ligands | 7 | 2002 | |
2003/0114,521 Oxamic acids and derivatives as thyroid receptor ligands | 2 | 2002 | |
2005/0054,727 Phenyl naphthol ligands for thyroid hormone receptor | 2 | 2004 | |
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5401772 Heteroacetic acid derivatives | 32 | 1993 | |
5569674 Heteroacetic acid derivatives | 27 | 1994 | |
5654468 Heteroacetic acid derivatives | 19 | 1996 | |
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5284971 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents | 34 | 1992 | |
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2004/0152,783 Controlled absorption of admixed thyroid hormone formulations | 2 | 2003 | |
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6117873 Substituted aminoalkane phosphonic acids | 11 | 1999 | |
6689896 Thyromimetic organic compounds | 2 | 2001 | |
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4673691 Human weight loss inducing method | 12 | 1984 | |
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5753254 Therapeutic agents containing thyroid hormones | 37 | 1996 | |
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5951989 Method for the treatment of dry skin | 54 | 1997 | |
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2004/0116,391 Stabilized thyroxine compounds | 5 | 2003 | |
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5232946 Phenylethanolamines, their use as pharmaceuticals and as performance enhancers in animals | 16 | 1990 | |
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5741803 Substituted thiazolidinedionle derivatives | 20 | 1995 | |
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6852706 Methods and compositions for healing heart wounds | 8 | 2001 | |
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6361992 Thyroid stimulating hormone superagonists | 27 | 1998 | |
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6194454 Cyano containing oxamic acids and derivatives as thyroid receptor ligands | 46 | 2000 | |
6326398 Oxamic acids and derivatives as thyroid receptor ligands | 9 | 2000 | |
6620830 Thyroid receptor ligands | 8 | 2001 | |
6545018 Oxamic acids and derivatives as thyroid receptor ligands | 6 | 2001 | |
6723744 Indole carboxylic acids as thyroid receptor ligands | 6 | 2002 | |
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6982348 Aminoethanol derivatives | 16 | 2002 | |
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4554290 Oxamic acid derivatives | 11 | 1984 | |
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5627173 Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders | 2 | 1996 | |
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6344481 Thyromimetic antiobesity agents | 6 | 2000 | |
6787652 6-Azauracil derivatives as thyroid receptor ligands | 8 | 2000 | |
6441015 Tetrazole compounds as thyroid receptor ligands | 6 | 2001 | |
6664291 Malonamic acids and derivatives thereof as thyroid receptor ligands | 5 | 2001 | |
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6716877 Method to treat chronic heart failure and/or elevated cholesterol levels | 3 | 2003 | |
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2004/0029,187 Systems and methods for detection of nuclear receptor function using reporter enzyme mutant complementation | 2 | 2003 | |
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6468755 Method for identifying compounds for treatment of insulin resistance | 2 | 2000 | |
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4426453 Derivatives of iodothyronine compounds and their use in an assay for the free iodothyronine compounds | 20 | 1981 | |
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5324522 Sustained release thyroactive composition | 26 | 1992 | |
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5663159 Prodrugs of phosphonates | 95 | 1994 | |
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6534676 Method to treat chronic heart failure and/or elevated cholesterol levels using 3,5-diiodothyropropionic acid and method to prepare same | 7 | 2001 | |
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6680340 Anti-hypercholesterolemic drug combination | 2 | 2003 | |
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5571840 Method for treating central nervous system ischemia | 26 | 1994 | |
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2004/0219,218 Pharmaceutical formulae for thyroid hormones and procedures for obtaining them | 3 | 2003 | |
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6236946 Nuclear receptor ligands and ligand binding domains | 5 | 1996 | |
5883294 Selective thyroid hormone analogs | 15 | 1997 | |
6266622 Nuclear receptor ligands and ligand binding domains | 4 | 1997 | |
6107517 Thyroid hormone analogues and methods for their preparation | 3 | 1999 | |
6555582 Eye treatments using synthetic thyroid hormone compositions | 5 | 1999 | |
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6221911 Uses for thyroid hormone compounds or thyroid hormone-like compounds | 20 | 1998 | |
6380255 Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds | 5 | 2000 | |
2002/0123,521 Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds | 4 | 2002 | |
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* 7514419 Phosphorus-containing thyromimetics | 5 | 2005 | |
2006/0046,980 Novel phosphorus-containing thyromimetics | 9 | 2005 | |
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* 6495533 Drugs containing phosphoric acid derivatives as the active ingredient | 2 | 2001 | |
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6414002 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | 57 | 2001 | |
6727271 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | 38 | 2002 | |
6673815 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | 46 | 2002 | |
6831102 Phenyl naphthol ligands for thyroid hormone receptor | 4 | 2002 | |
6747048 Pyridine-based thyroid receptor ligands | 4 | 2003 | |
6875782 Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | 17 | 2003 | |
2005/0004,184 Thyroid receptor ligands | 5 | 2004 | |
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5116828 Pharmaceutical composition for treatment of osteoporosis | 41 | 1990 | |
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6545150 Certain benzothiazine dioxide endothelin antagonists and processes for their preparation | 1 | 2001 | |
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5922775 Method of treating malignant tumors with ketone thyroxine analogues having no significant hormonal activity | 11 | 1997 | |
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6414026 Compounds which interact with the thyroid hormone receptor for the treatment of fibrotic disease | 10 | 2001 | |
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4766121 Pyridyl and pyridazinyl substituted thyronine compounds having selective thyromimetic activity | 25 | 1986 | |
4826876 Chemical compounds having selective thyromimetic activity | 17 | 1987 | |
4910305 Pyridyl and pyridazinyl substituted thyronine compounds | 14 | 1988 | |
5061798 Benzyl pyridyl and pyridazinyl compounds | 19 | 1989 | |
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6608049 Indazoles | 6 | 2001 | |
6794406 Indole derivatives | 4 | 2001 | |
7015246 Benzofuran derivatives | 2 | 2002 | |
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5158978 Thyroid hormone treatment of acute cardiovascular compromise | 32 | 1991 | |
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2004/0142,868 Method of treating liver steatosis in a mammal | 2 | 2004 | |
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* 5519163 Inhibitors of phosphoinositide-specific phospholipase C | 4 | 1993 | |
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6566372 Bicyclic androgen and progesterone receptor modulator compounds and methods | 40 | 2000 | |
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5854282 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | 11 | 1997 | |
* 6465687 Thyroid receptor ligands and method | 3 | 2000 | |
6492424 Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | 2 | 2001 | |
6806381 Process for the preparation of aniline-derived thyroid receptor ligands | 4 | 2002 | |
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4423227 Process for the preparation of reactive, couplable derivatives of the thyroid hormones | 3 | 1981 | |
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2003/0153,513 Preventives or remedies for obesity or fatty liver | 3 | 2003 |
Patent Citation Ranking
Forward Cite Landscape
Patent Info | (Count) | # Cites | Year |
---|---|---|---|
|
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* 2010/0081,634 Novel Phosphorus-Containing Thyromimetics | 1 | 2006 | |
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8201615 Heat storage devices | 4 | 2009 | |
* 8091613 Thermal energy storage materials | 4 | 2009 | |
* 2009/0250,189 HEAT STORAGE DEVICES | 19 | 2009 | |
8590598 Devices for storing and discharging heat and methods thereof | 1 | 2012 | |
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* 8859098 Acrylic adhesion promoters | 0 | 2012 | |
* 2013/0309,508 ACRYLIC ADHESION PROMOTERS | 0 | 2012 |
Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
---|---|---|---|---|
7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | May 9, 2018 |
11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | May 9, 2022 |
Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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