Piperidinyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
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United States of America Patent
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Nov 9, 2010
Grant Date -
Apr 2, 2009
app pub date -
Apr 27, 2007
filing date -
Apr 28, 2006
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Expired
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Abstract
The present invention discloses novel compounds of Formula I:having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.
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