Method for making analgesics
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United States of America Patent
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Dec 14, 2010
Grant Date -
Jun 19, 2008
app pub date -
Oct 3, 2007
filing date -
Dec 14, 2006
priority date (Note) -
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Abstract
Improved analgesic oxymorphone hydrochloride contains less than 10 ppm of alpha, beta unsaturated ketones and pharmaceutical preparations comprising such oxymorphone hydrochloride. The oxymorphone hydrochloride is produced by reducing a starting material oxymorphone hydrochloride using gaseous hydrogen and under specified acidity, solvent system and temperature conditions. A specific polymorph of oxymorphone hydrochloride may be obtained by hydration.
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