US Patent No: 7,853,329

Number of patents in Portfolio can not be more than 2000

Monitoring efficacy of neural modulation therapy

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Abstract

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A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CYBERONICS, INC.HOUSTON, TX192

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DiLorenzo, Daniel John Seattle, US 34 3075

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (22)
4,505,275 Treatment method and instrumentation system 50 1982
4,852,573 Implantable neural electrode 417 1987
4,926,865 Microcomputer-based nerve and muscle stimulator 215 1989
5,265,619 Process and device for measuring vibrations, in particular nervous trembling in living organisms 43 1991
5,486,999 Apparatus and method for categorizing health care utilization 123 1994
6,066,163 Adaptive brain stimulation method and system 444 1996
5,611,350 Method and apparatus for facilitating recovery of patients in deep coma 204 1996
5,782,874 Method and apparatus for manipulating nervous systems 75 1997
5,899,922 Manipulation of nervous systems by electric fields 67 1997
6,081,744 Electric fringe field generator for manipulating nervous systems 41 1998
6,205,359 Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator 303 1998
6,167,304 Pulse variability in electric field manipulation of nervous systems 75 1999
6,463,328 Adaptive brain stimulation method and system 468 2000
6,356,788 APPARATUS AND METHOD FOR ADJUNCT (ADD-ON) THERAPY FOR DEPRESSION, MIGRAINE, NEUROPSYCHIATRIC DISORDERS, PARTIAL COMPLEX EPILEPSY, GENERALIZED EPILEPSY AND INVOLUNTARY MOVEMENT DISORDERS UTILIZING AN EXTERNAL STIMULATOR 157 2000
2002/0002,390 Implantable neurostimulator having a data communication link 89 2001
6,778,854 Methods of indirectly stimulating the vagus nerve with an electrical field 145 2002
2005/0197,590 System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 153 2002
2003/0176,806 Method and system for an intelligent supervisory control system 37 2003
2004/0073,273 Adaptive electric field modulation of neural systems 89 2003
2006/0142,822 Externally activated neuro-implant which directly transmits therapeutic signals 47 2003
2005/0124,863 Drug profiling apparatus and method 27 2004
2005/0228,461 Stimulation methodologies and apparatus for control of brain states 37 2005
 
Huntington Institute of Applied Research (1)
4,573,481 Implantable electrode array 508 1984
 
Huntington Medical Research Institutes (1)
4,920,979 Bidirectional helical electrode for nerve stimulation 237 1988
 
Pain Suppression Labs, Inc. (1)
4,844,075 Transcranial stimulation for the treatment of cerebral palsy 98 1986
 
UNIVERSITY OF UTAH (2)
5,215,088 Three-dimensional electrode device 311 1989
5,361,760 Impact inserter mechanism for implantation of a biomedical device 55 1993
 
NEURALIEVE, INC. (1)
6,402,678 Means and method for the treatment of migraine headaches 133 2000
 
DILORENZO BIOMEDICAL, LLC (1)
2003/0018,367 Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease 248 2002
 
Lockheed Martin Energy Research Corp. (2)
5,815,413 Integrated method for chaotic time series analysis 47 1997
6,484,132 Condition assessment of nonlinear processes 132 2000
 
Lockheed Martin Energy Systems, Inc. (3)
5,626,145 Method and apparatus for extraction of low-frequency artifacts from brain waves for alertness detection 73 1996
5,743,860 Apparatus and method for epileptic seizure detection using non-linear techniques 118 1996
5,857,978 Epileptic seizure prediction by non-linear methods 102 1996
 
HEALTH RESEARCH, INC. (1)
5,638,826 Communication method and system using brain waves for multidimensional control 84 1995
 
ASPECT MEDICAL SYSTEMS, INC. (1)
5,010,891 Cerebral biopotential analysis system and method 96 1989
 
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (9)
4,991,582 Hermetically sealed ceramic and metal package for electronic devices implantable in living bodies 258 1989
5,312,439 Implantable device having an electrolytic storage electrode 320 1991
5,193,539 Implantable microstimulator 621 1991
5,193,540 Structure and method of manufacture of an implantable microstimulator 592 1991
5,324,316 Implantable microstimulator 462 1993
5,405,367 Structure and method of manufacture of an implantable microstimulator 404 1993
5,571,148 Implantable multichannel stimulator 259 1994
2003/0167,078 Pulsed magnetic control system for interlocking functions of battery powered living tissue stimulators 23 2002
6,990,372 Programmable signal analysis device for detecting neurological signals in an implantable device 69 2002
 
MEDPOINTE HEALTHCARE, INC.(F/K/A CARTER-WALLACE, INC.) (2)
4,978,680 Method for the prevention and control of epileptic seizure 38 1989
5,082,861 Method for the prevention and control of epileptic seizure associated with complex partial seizures 36 1990
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
6,304,775 Seizure warning and prediction 154 1999
 
Glaxo Inc. (1)
5,376,359 Method of stabilizing aerosol formulations 130 1992
 
KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (1)
4,471,786 Telemetering intracranial pressure transducer 107 1982
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (2)
4,838,272 Method and apparatus for adaptive closed loop electrical stimulation of muscles 70 1987
5,269,315 Determining the nature of brain lesions by electroencephalography 43 1991
 
Intermedics, Inc. (1)
5,978,710 Implantable cardiac stimulator with safe noise mode 147 1998
 
Meda Pharmaceuticals Inc. (1)
5,292,772 Method for the prevention and control of epileptic seizure associated with Lennox-Gastaut syndrome 34 1992
 
DEVICE DEVELOPMENTS, INC. (1)
4,566,464 Implantable epilepsy monitor apparatus 98 1981
 
THE CLEVELAND CLINIC FOUNDATION (2)
2005/0049,649 Electrical stimulation of the brain 38 2003
2005/0010,261 Application of stimulus to white matter to induce a desired physiological response 37 2004
 
UNIVERSITY OF WASHINGTON (1)
5,349,962 Method and apparatus for detecting epileptic seizures 72 1993
 
Center for Innovative Technology (1)
5,190,029 Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content 137 1991
 
BIOMET MICROFIXATION, LLC (1)
5,578,036 Method and apparatus for fixation of bone during surgical procedures 96 1993
 
UNIVERSITY OF KANSAS (2)
5,995,868 System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 360 1997
6,549,804 System for the prediction, rapid detection, warning, prevention or control of changes in activity states in the brain of a subject 212 1999
 
Circadian Technologies, Inc. (1)
6,511,424 Method of and apparatus for evaluation and mitigation of microsleep events 70 2000
 
DUKE UNIVERSITY (2)
5,626,627 Electroconvulsive therapy method using ICTAL EEG data as an indicator of ECT seizure adequacy 37 1995
2003/0083,716 Intelligent brain pacemaker for real-time monitoring and controlling of epileptic seizures 117 2001
 
Somatics, Inc. (5)
4,873,981 Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures 46 1988
4,878,498 Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures 47 1989
5,269,302 Electroconvulsive therapy apparatus and method for monitoring patient seizures 96 1992
5,769,778 Medical magnetic non-convulsive stimulation therapy 141 1997
6,117,066 Prevention of seizure arising from medical magnetoictal non-convulsive stimulation therapy 77 1998
 
INTELLIPATCH, INC. (1)
2003/0144,829 System and method for sensing and evaluating physiological parameters and modeling an adaptable predictive analysis for symptoms management 86 2003
 
GLOBAL SUN TECHNOLOGY INC. (1)
2005/0059,867 Method for monitoring temperature of patient 38 2003
 
CNS Response (1)
6,622,036 Method for classifying and treating physiologic brain imbalances using quantitative EEG 100 2000
 
CYBERONICS, INC. (45)
4,979,511 Strain relief tether for implantable electrode 252 1989
5,154,172 Constant current sources with programmable voltage source 260 1989
5,188,104 Treatment of eating disorders by nerve stimulation 518 1991
5,269,303 Treatment of dementia by nerve stimulation 439 1991
5,215,086 Therapeutic treatment of migraine symptoms by stimulation 495 1991
5,251,634 Helical nerve electrode 298 1991
5,299,569 Treatment of neuropsychiatric disorders by nerve stimulation 603 1991
5,335,657 Therapeutic treatment of sleep disorder by nerve stimulation 747 1991
5,205,285 Voice suppression of vagal stimulation 249 1991
5,222,494 Implantable tissue stimulator output stabilization system 238 1991
5,231,988 Treatment of endocrine disorders by nerve stimulation 542 1991
5,215,089 Electrode assembly for nerve stimulation 236 1991
5,304,206 Activation techniques for implantable medical device 443 1991
5,237,991 Implantable medical device with dummy load for pre-implant testing in sterile package and facilitating electrical lead connection 155 1991
5,179,950 Implanted apparatus having micro processor controlled current and voltage sources with reduced voltage levels when not providing stimulation 209 1991
5,186,170 Simultaneous radio frequency and magnetic field microprocessor reset circuit 187 1991
5,235,980 Implanted apparatus disabling switching regulator operation to allow radio frequency signal reception 188 1991
5,330,515 Treatment of pain by vagal afferent stimulation 442 1992
5,263,480 Treatment of eating disorders by nerve stimulation 480 1992
5,351,394 Method of making a nerve electrode array 251 1992
5,531,778 Circumneural electrode assembly 296 1994
5,571,150 Treatment of patients in coma by nerve stimulation 417 1994
5,540,730 Treatment of motility disorders by nerve stimulation 607 1995
5,707,400 Treating refractory hypertension by nerve stimulation 630 1995
5,928,272 Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity 442 1998
6,366,813 Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease 409 1999
6,587,719 Treatment of obesity by bilateral vagus nerve stimulation 340 1999
6,473,644 Method to enhance cardiac capillary growth in heart failure patients 424 1999
6,609,025 Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation 282 2001
6,622,038 Treatment of movement disorders by near-diaphragmatic nerve stimulation 195 2001
6,622,047 Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation 201 2001
6,600,956 Circumneural electrode assembly 372 2001
6,622,041 Treatment of congestive heart failure and autonomic cardiovascular drive disorders 406 2001
7,231,254 Closed-loop feedback-driven neuromodulation 207 2004
2006/0293,720 Closed-loop feedback-driven neuromodulation 158 2005
2006/0224,191 Systems and methods for monitoring a patient's neurological disease state 102 2005
2007/0142,862 Systems and methods for monitoring a patient's neurological disease state 89 2005
2007/0149,952 Systems and methods for characterizing a patient's propensity for a neurological event and for communicating with a pharmacological agent dispenser 41 2005
2007/0150,024 Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders 93 2005
2007/0150,025 Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders 94 2005
2007/0073,355 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 150 2006
2008/0161,712 Low Power Device With Contingent Scheduling 65 2006
2008/0161,713 Low Power Device With Variable Scheduling 68 2006
2007/0161,919 Methods and systems for continuous EEG monitoring 109 2006
2007/0167,991 Methods and systems for determining subject-specific parameters for a neuromodulation therapy 94 2006
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (2)
6,442,421 METHOD FOR THE MEDICAL MONITORING IN REAL TIME OF A PATIENT FROM THE ANALYSIS OF ELECTROENCEPHALOGRAMS TO CHARACTERIZE AND DIFFERENTIATE BETWEEN PHYSIOLOGICAL OR PATHOLOGICAL CONDITIONS, AND A METHOD FOR ANTICIPATING EPILEPTIC SEIZURES 51 2000
2006/0015,034 Analysis method and real time medical or cognitive monitoring device based on the analysis of a subject's cerebral electromagnetic use of said method for characterizing and differenting physiological and pathological states 30 2003
 
BIOMETIX PTY. LTD. (1)
2003/0174,554 Security container for medicines and system for filing prescriptions 25 2003
 
PURDUE RESEARCH FOUNDATION (2)
5,690,681 Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation 328 1996
5,916,239 Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation 458 1997
 
NATUS MEDICAL INCORPORATED (2)
6,591,132 Artifact detection in encephalogram data using an event model 31 2001
6,931,274 Processing EEG signals to predict brain damage 54 2002
 
VAN DEN TOORN, RICK, MR (2)
4,768,176 Apparatus for alerting a patient to take medication 110 1984
4,768,177 Method of and apparatus for alerting a patient to take medication 109 1987
 
LIFELINE SYSTEMS COMPANY (1)
5,971,594 Medication dispensing system 112 1998
 
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (1)
2004/0176,359 Intranasal Benzodiazepine compositions 28 2004
 
PERSYST DEVELOPMENT CORPORATION (1)
6,735,467 Method and system for detecting seizures using electroencephalograms 33 2002
 
Vitatron Medical, B.V. (1)
5,293,879 System an method for detecting tremors such as those which result from parkinson's disease 93 1991
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (3)
5,343,064 Fully integrated single-crystal silicon-on-insulator process, sensors and circuits 172 1988
5,314,458 Single channel microstimulator 202 1993
2006/0200,038 Noninvasive nonlinear systems and methods for predicting seizure 23 2003
 
3M INNOVATIVE PROPERTIES COMPANY (1)
5,776,434 Medicinal aerosol formulations 56 1997
 
CONSOLIDATED RESEARCH OF RICHMOND, INC. (1)
5,813,993 Alertness and drowsiness detection and tracking system 119 1996
 
CEDARS-SINAI MEDICAL CENTER (2)
6,328,699 Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure 282 2000
2004/0147,969 System for detecting, diagnosing, and treating cardiovascular disease 210 2003
 
BIOTRONIK MESS-UND THERAPIEGERAETE GMBH & CO. INGENIEURBUERO BERLIN (3)
5,913,881 Metallic housing for implant with recesses for eddy current reduction 42 1997
6,553,262 Arrangement for patient monitoring 69 1999
6,893,395 Method and apparatus for data transmission between an electromedical implant and an external apparatus 77 2000
 
BIO NEURONICS CORPORATION (1)
2008/0114,417 Systems and methods of reducing artifact in neurological stimulation systems 69 2006
 
Sam Technology, Inc. (2)
5,513,649 Adaptive interference canceler for EEG movement and eye artifacts 89 1994
6,434,419 Neurocognitive ability EEG measurement method and system 92 2000
 
ROYAL POSTGRADUATE MEDICAL SCHOOL (1)
5,181,520 Method and apparatus for analyzing an electro-encephalogram 33 1990
 
NEUROMEDICS TECHNOLOGY, INC. (1)
5,365,939 Method for evaluating and treating an individual with electroencephalographic disentrainment feedback 57 1993
 
THE JOHNS HOPKINS UNIVERSITY (4)
4,494,950 Plural module medication delivery system 971 1982
5,311,876 Automatic detection of seizures using electroencephalographic signals 160 1992
6,248,126 Technique for using heat flow management to treat brain disorders 153 1999
2005/0149,123 Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders 54 2005
 
LUMOS LABS, INC. (1)
6,280,198 Remote computer implemented methods for cognitive testing 82 1999
 
Beekley Corporation (1)
2004/0243,146 Method and apparatus for supporting a medical device 51 2003
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (12)
6,051,017 Implantable microstimulator and systems employing the same 468 1998
6,782,292 System and method for treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion 144 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2004/0172,089 FULLY IMPLANTABLE MINIATURE NEUROSTIMULATOR FOR STIMULATION AS A THERAPY FOR EPILEPSY 136 2002
7,177,701 System for permanent electrode placement utilizing microelectrode recording methods 53 2003
 
NEUROKINETIC APS C/O OSTJYDSK INNOVATION A/S (1)
6,343,226 Multifunction electrode for neural tissue stimulation 139 1999
 
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (1)
6,547,746 Method and apparatus for determining response thresholds 61 2001
 
ADAMAS PHARMACEUTICALS, INC. (1)
2005/0209,218 Methods and compositions for the treatment of psychiatric conditions 54 2005
 
Biomed Concepts, Inc. (1)
4,590,946 Surgically implantable electrode for nerve bundles 243 1984
 
NEUROPACE (1)
6,016,449 System for treatment of neurological disorders 554 1997
 
Advanced Neuromodulation Systems, Inc. (6)
4,612,934 Non-invasive multiprogrammable tissue stimulator 327 1984
4,793,353 Non-invasive multiprogrammable tissue stimulator and method 294 1986
7,010,351 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 128 2001
2004/0181,263 System and method for treating Parkinson's Disease and other movement disorders 96 2003
6,973,342 Flexible bio-probe assembly 109 2004
2005/0021,105 Methods and apparatus for effectuating a change in a neural-function of a patient 105 2004
 
BETH ISRAEL HOSPITAL ASSOCIATION A NON-PROFIT CORPORATION OF MA (1)
5,222,503 Ambulatory electroencephalography system 65 1991
 
IPXMEDICAL, LLC (1)
6,534,693 Surgically implanted devices having reduced scar tissue formation 81 2001
 
HEMPELMAN, PHILIP (1)
5,070,873 Method of and apparatus for electrically stimulating quadriceps muscles of an upper motor unit paraplegic 73 1987
 
MED-EL ELEKTROMEDIZINISCHE GERAETE GMBH (1)
6,358,281 Totally implantable cochlear prosthesis 172 1999
 
BIOFIELD CORP. (2)
5,697,369 Method and apparatus for disease, injury and bodily condition screening or sensing 105 1994
5,715,821 Neural network method and apparatus for disease, injury and bodily condition screening or sensing 51 1995
 
AEQUITRON MEDICAL, INC. (1)
4,579,125 Real-time EEG spectral analyzer 76 1984
 
BIO CONTROL MEDICAL (B.C.M.) LTD. (1)
6,684,105 Treatment of disorders by unidirectional nerve stimulation 325 2001
 
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (1)
5,555,191 Automated statistical tracker 104 1994
 
Remon Medical Technologies, Ltd. (1)
5,704,352 Implantable passive bio-sensor 234 1995
 
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY, ACTING THROUGH LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER (1)
2006/0173,510 Medical devices for the detection, prevention and/or treatment of neurological disorders, and methods related thereto 101 2005
 
Pacesetter, Inc. (2)
2005/0033,369 Data Feedback loop for medical therapy adjustment 31 2003
7,174,212 Implantable medical device having a casing providing high-speed telemetry 28 2003
 
PACESETTER AB (1)
5,405,365 Implantable medical device having means for stimulating tissue contractions with adjustable stimulation intensity and a method for the operation of such a device 42 1994
 
TRILOBOT, INC. (1)
6,042,548 Virtual neurological monitor and method 92 1997
 
Ad-Tech Medical Instrument Corp. (1)
5,097,835 Subdural electrode with improved lead connection 50 1990
 
TOTTS GAP MEDICAL RESEARCH LABORATORIES, INC. (1)
5,720,294 PD2I electrophysiological analyzer 51 1996
 
NELLCOR PURITAN BENNETT LLC (1)
5,458,117 Cerebral biopotential analysis system and method 95 1994
 
LUCENT TECHNOLOGIES INC. (1)
5,649,068 Pattern recognition system using support vectors 114 1996
 
Zealear; David L. (1)
4,817,628 System and method for evaluating neurological function controlling muscular movements 129 1985
 
Hamit-Darwin-Fresh, Inc. (1)
6,309,406 Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening 41 1999
 
Sigmedics, Inc. of Delaware (1)
5,016,635 Control of FNS via pattern variations of response EMG 60 1988
 
EMORY UNIVERSITY (1)
6,171,239 Systems, methods, and devices for controlling external devices by signals derived directly from the nervous system 204 1998
 
Cardiac Intelligence Corporation (2)
6,221,011 System and method for determining a reference baseline of individual patient status for use in an automated collection and analysis patient care system 353 1999
6,358,203 System and method for automated collection and analysis of patient information retrieved from an implantable medical device for remote patient care 282 2001
 
NEUROVISTA CORPORATION (1)
2010/0023,089 Controlling a Subject's Susceptibility to a Seizure 24 2009
 
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (1)
6,678,548 Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device 61 2000
 
Cardiac Pacemakers, Inc. (6)
5,342,408 Telemetry system for an implantable cardiac device 278 1993
5,876,424 Ultra-thin hermetic enclosure for implantable medical devices 51 1997
2005/0043,772 Therapy triggered by prediction of disordered breathing 139 2003
2005/0187,789 Advanced patient and medication therapy management system and method 108 2004
2005/0137,640 Adaptive safety pacing 33 2004
2005/0182,308 System and method for determining a reference baseline record 50 2005
 
Cochlear Corporation (1)
4,785,827 Subcutaneous housing assembly 48 1987
 
CIT GROUP/BUSINESS CREDIT, INC., THE (5)
4,702,254 Neurocybernetic prosthesis 450 1985
4,867,164 Neurocybernetic prosthesis 417 1987
5,025,807 Neurocybernetic prosthesis 375 1989
5,540,734 Cranial nerve stimulation treatments using neurocybernetic prosthesis 559 1994
5,700,282 Heart rhythm stabilization using a neurocybernetic prosthesis 497 1995
 
Universal Hedonics (1)
6,488,617 Method and device for producing a desired brain state 113 2000
 
FIRST FIDELITY BANK, NATIONAL ASSOCIATION, AS AGENT (1)
4,679,144 Cardiac signal real time monitor and method of analysis 193 1984
 
ALLERGAN, INC. (2)
6,620,415 Parkinson's disease treatment 90 2001
6,921,538 Therapeutic treatments for neuropsychiatric disorders 33 2002
 
Angel Medical Systems, Inc. (1)
2004/0199,212 External patient alerting system for implantable devices 126 2003
 
GEORGIA TECH RESEARCH CORPORATION (1)
6,658,287 Method and apparatus for predicting the onset of seizures based on features derived from signals indicative of brain activity 122 2001
 
MORGAN STANLEY SENIOR FUNDING, INC., AS AGENT (5)
2004/0133,696 Media role management in a video conferencing network 4 2003
2004/0133,696 Media role management in a video conferencing network 4 2003
2004/0133,696 Media role management in a video conferencing network 4 2003
2004/0133,696 Media role management in a video conferencing network 4 2003
2004/0133,696 Media role management in a video conferencing network 4 2003
 
MEDTRONIC TRANSNEURONIX, INC. (1)
2005/0027,328 Minimally invasive surgery placement of stimulation leads in mediastinal structures 41 2004
 
The Penn State Research Foundation (1)
2002/0035,338 Epileptic seizure detection and prediction by self-similar methods 25 2000
 
Neurospace, Inc. (1)
6,944,501 Neurostimulator involving stimulation strategies and process for using it 167 2000
 
BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (1)
6,571,123 Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation 78 2000
 
WILLIAM REBER, L.L.C. (1)
5,950,632 Medical communication apparatus, system, and method 280 1997
 
EURO-CELTIQUE S.A. (1)
6,921,541 Formulations and methods for providing prolonged local anesthesia 78 2002
 
MASSACHUSETTS EYE & EAR INFIRMARY (3)
5,411,540 Method and apparatus for preferential neuron stimulation 178 1993
5,476,494 Low pressure neural contact structure 81 1994
5,575,813 Low-pressure neural contact structure 121 1995
 
LEVEN, SAMUEL J. (1)
5,392,788 Method and device for interpreting concepts and conceptual thought from brainwave data and for assisting for diagnosis of brainwave disfunction 88 1993
 
NEUROTECH S.A. (1)
5,474,547 Implanting devices for the focal release of neuroinhibitory compounds 91 1993
 
MEDTRONIC, INC. (53)
5,031,618 Position-responsive neuro stimulator 241 1990
5,342,409 Position-responsive neuro stimulator 422 1991
5,300,094 Servo muscle control 84 1992
6,249,703 Handheld patient programmer for implantable human tissue stimulator 146 1994
5,683,422 Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation 222 1996
5,716,377 Method of treating movement disorders by brain stimulation 316 1996
6,094,598 Method of treating movement disorders by brain stimulation and drug infusion 186 1996
5,711,316 Method of treating movement disorders by brain infusion 280 1996
5,735,814 Techniques of treating neurodegenerative disorders by brain infusion 131 1996
5,713,923 Techniques for treating epilepsy by brain stimulation and drug infusion 232 1996
5,782,798 Techniques for treating eating disorders by brain stimulation and drug infusion 191 1996
5,752,979 Method of controlling epilepsy by brain stimulation 135 1996
5,800,474 Method of controlling epilepsy by brain stimulation 116 1996
5,957,861 Impedance monitor for discerning edema through evaluation of respiratory rate 409 1997
5,792,186 Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation 188 1997
5,832,932 Method of treating movement disorders by brain infusion 195 1997
5,833,709 Method of treating movement disorders by brain stimulation 252 1997
6,042,579 Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain 127 1997
5,975,085 Method of treating schizophrenia by brain stimulation and drug infusion 135 1997
6,128,537 Techniques for treating anxiety by brain stimulation and drug infusion 152 1997
5,824,021 Method and apparatus for providing feedback to spinal cord stimulation for angina 200 1997
5,814,014 Techniques of treating neurodegenerative disorders by brain infusion 135 1997
5,941,906 Implantable, modular tissue stimulator 331 1997
5,978,702 Techniques of treating epilepsy by brain stimulation and drug infusion 212 1997
6,018,682 Implantable seizure warning system 232 1998
6,374,140 Method and apparatus for treating seizure disorders by stimulating the olfactory senses 128 1998
6,227,203 Techniques for controlling abnormal involuntary movements by brain stimulation and drug infusion 129 1998
6,109,269 Method of treating addiction by brain infusion 106 1999
6,176,242 Method of treating manic depression by brain infusion 141 1999
6,356,784 Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus 169 1999
6,386,882 Remote delivery of software-based training for implantable medical device systems 129 1999
6,337,997 Implantable seizure warning system 176 1999
6,471,645 Communications system for an implantable device and a drug dispenser 224 1999
6,263,237 Techniques for treating anxiety disorders by brain stimulation and drug infusion 129 2000
6,453,198 Power management for an implantable medical device 125 2000
6,687,538 Trial neuro stimulator with lead diagnostics 183 2000
6,443,891 Telemetry modulation protocol system for medical devices 178 2000
6,571,125 Drug delivery device 166 2001
6,671,555 Closed loop neuromodulation for suppression of epileptic activity 148 2001
6,923,784 Therapeutic treatment of disorders based on timing information 151 2001
6,901,292 Control of externally induced current in an implantable pulse generator 76 2001
6,937,891 Independent therapy programs in an implantable medical device 44 2002
6,950,706 Wave shaping for an implantable medical device 49 2002
6,912,419 Method and device for electronically controlling the beating of a heart 95 2003
2004/0077,995 Communications system for an implantable medical device and a delivery device 125 2003
2004/0133,119 Scoring of sensed neurological signals for use with a medical device system 123 2003
2004/0138,516 Configuring and testing treatment therapy parameters for a medical device system 113 2003
2004/0138,517 Multi-modal operation of a medical device system 158 2003
2004/0138,647 Cycle mode providing redundant back-up to ensure termination of treatment therapy in a medical device system 107 2003
2004/0138,711 Control of treatment therapy during start-up and during operation of a medical device system 113 2003
2004/0158,119 Screening techniques for management of a nervous system disorder 164 2003
2005/0113,885 Patient notification of medical device telemetry session 45 2003
2005/0182,464 Methods and apparatus for securing a therapy delivery device within a burr hole 39 2005
 
NEURO AND CARDIAC TECHNOLOGIES, LLC (5)
6,366,814 External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders 326 2000
6,668,191 Apparatus and method for electrical stimulation adjunct (add-on) therapy of atrial fibrillation, inappropriate sinus tachycardia, and refractory hypertension with an external stimulator 204 2001
6,760,626 Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system 203 2001
6,879,859 External pulse generator for adjunct (add-on) treatment of obesity, eating disorders, neurological, neuropsychiatric, and urological disorders 154 2002
2005/0143,787 Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator 217 2005
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
4,955,380 Flexible measurement probes 59 1988
7,212,851 Microstructured arrays for cortex interaction and related methods of manufacture and use 50 2002
 
NEUROPACE, INC. (29)
6,061,593 EEG d-c voltage shift as a means for detecting the onset of a neurological event 261 1998
5,938,689 Electrode configuration for a brain neuropacemaker 150 1998
6,006,124 Means and method for the placement of brain electrodes 225 1998
6,161,045 Method for determining stimulation parameters for the treatment of epileptic seizures 167 1999
6,230,049 Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes 179 1999
6,128,538 Means and method for the treatment of neurological disorders 280 1999
6,134,474 Responsive implantable system for the treatment of neurological disorders 316 2000
6,473,639 Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures 282 2000
6,466,822 Multimodal neurostimulator and process of using it 266 2000
6,427,086 Means and method for the intracranial placement of a neurostimulator 239 2000
6,353,754 System for the creation of patient specific templates for epileptiform activity detection 163 2000
6,354,299 Implantable device for patient communication 208 2000
6,360,122 Data recording methods for an implantable device 261 2000
6,591,138 Low frequency neurostimulator for the treatment of neurological disorders 182 2000
7,089,059 Predicting susceptibility to neurological dysfunction based on measured neural electrophysiology 166 2000
6,529,774 Extradural leads, neurostimulator assemblies, and processes of using them for somatosensory and brain stimulation 194 2000
6,591,137 Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders 219 2000
6,597,954 System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes 285 2000
6,618,623 Ferrule for cranial implant 96 2000
6,480,743 System and method for adaptive brain stimulation 391 2001
2003/0144,711 Systems and methods for interacting with an implantable medical device 141 2002
2002/0099,412 Methods for using an implantable device for patient communication 193 2002
2002/0169,485 Differential neurostimulation therapy driven by physiological context 269 2002
2003/0195,588 External ear canal interface for the treatment of neurological disorders 161 2002
2003/0028,072 Low frequency magnetic neurostimulator for the treatment of neurological disorders 96 2002
2004/0153,129 System and method for controlling neurological disorders with spatially separated detection and therapy locations 122 2003
2005/0222,641 Neurostimulator involving stimulation strategies and process for using it 41 2005
* 2006/0212,092 Systems and methods for interacting with an implantable medical device 35 2006
2006/0212,093 Differential neurostimulation therapy driven by physiological therapy 38 2006
 
Flint Hills Scientific, LLC (4)
6,341,236 Vagal nerve stimulation techniques for treatment of epileptic seizures 511 1999
6,560,486 Bi-directional cerebral interface system 136 1999
6,768,969 Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes 109 2001
6,934,580 Stimulation methodologies and apparatus for control of brain states 162 2003
 
JPMORGAN CHASE BANK, N.A. (1)
2002/0062,071 Manual and automatic probe calibration 14 2001
 
NEW YORK UNIVERSITY (3)
4,279,258 Rapid automatic electroencephalographic evaluation 107 1980
4,545,388 Self-normed brain state monitoring 43 1983
6,052,619 Brain function scan system 132 1997
 
ADVANCED BIONICS, LLC (1)
6,411,854 Implanted ceramic case with enhanced ceramic case strength 33 1999
 
Bionova Technologies Inc. (1)
7,373,198 Method and apparatus for the estimation of anesthetic depth using wavelet analysis of the electroencephalogram 30 2003
 
Mayo Foundation for Medical Education and Research Image -Guided Neurologics, Inc. (1)
2007/0250,077 DEVICE FOR IMMOBILIZING A PRIMARY INSTRUMENT AND METHOD THEREFOR 26 2007
 
GEORGE MASON UNIVERSITY (1)
6,665,562 Adaptive electric field modulation of neural systems 110 2000
 
THE MCLEAN HOSPITAL CORPORATION (1)
6,572,528 Magnetic field stimulation techniques 70 2001
 
CHILDREN'S MEDICAL CENTER CORPORATION (4)
4,407,299 Brain electrical activity mapping 59 1981
4,408,616 Brain electricaL activity mapping 56 1981
4,421,122 Brain electrical activity mapping 69 1981
RE34015 Brain electrical activity mapping 100 1987
 
LIFEWATCH TECHNOLOGIES, INC. (1)
5,931,791 Medical patient vital signs-monitoring apparatus 311 1997
 
CVRX, INC. (1)
2005/0096,710 Baroreceptor activation for epilepsy control 113 2004
 
APREX CORPORATION (1)
5,917,429 Contactless communication system 79 1996
 
EnteroMedics Inc. (1)
2005/0070,970 Movement disorder stimulation with neural block 81 2004
 
RDM Consultants Ltd. (1)
5,816,247 Monitoring an EEG 52 1996
 
Advanced Brain Monitoring, Inc. (1)
6,496,724 Method for the quantification of human alertness 59 1999
 
CASE WESTERN RESERVE UNIVERSITY (1)
5,167,229 Functional neuromuscular stimulation system 153 1986
 
BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (1)
6,339,725 Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation 186 2000
 
JORDAN NEUROSCIENCE, INC. (1)
6,510,340 Method and apparatus for electroencephalography 69 2001
 
MEDSERV GROUP, INC. (1)
5,549,656 Combination neuromuscular stimulator and electromyograph system 186 1995
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
CYBERONICS, INC. (5)
8,849,390 Processing for multi-channel signals 0 2009
8,588,933 Medical lead termination sleeve for implantable medical devices 1 2010
8,786,624 Processing for multi-channel signals 0 2010
8,543,199 Implantable systems and methods for identifying a contra-ictal condition in a subject 0 2011
9,289,595 Medical lead termination sleeve for implantable medical devices 0 2013
 
Flint Hills Scientific, LLC (2)
* 8,560,073 System and apparatus for automated quantitative assessment, optimization and logging of the effects of a therapy 1 2010
* 2011/0160,795 SYSTEM AND APPARATUS FOR AUTOMATED QUANTITATIVE ASSESSMENT, OPTIMIZATION AND LOGGING OF THE EFFECTS OF A THERAPY 2 2010
 
NEUROPACE, INC. (7)
8,073,544 Neurostimulator involving stimulation strategies and process for using it 3 2005
8,412,333 Neurostimulator involving stimulation strategies and process for using it 0 2011
8,326,417 Neurostimulator involving stimulation strategies and process for using it 0 2011
8,224,452 Differential neurostimulation therapy driven by physiological therapy 0 2011
8,423,145 Differential neurostimulation therapy driven by physiological therapy 0 2012
8,694,106 Neurostimulator involving stimulation strategies and process for using it 0 2013
8,934,980 Differential neurostimulation therapy driven by physiological therapy 0 2013
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (5)
* 8,155,750 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 4 2009
* 2010/0023,090 SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMODATION TO ELETRICAL STIMULATION 6 2009
* 8,315,707 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 0 2012
* 2012/0179,222 SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMMODATION TO ELECTRICAL STIMULATION 1 2012
8,660,644 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 0 2012
 
DIGNITY HEALTH (2)
9,289,599 Vagus nerve stimulation method 0 2012
9,108,041 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 0 2013
 
CATHOLIC HEALTHCARE WEST (D/B/A ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER) (1)
8,738,126 Synchronization of vagus nerve stimulation with the cardiac cycle of a patient 1 2009
* Cited By Examiner

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