US Patent No: 7,853,329

Number of patents in Portfolio can not be more than 2000

Monitoring efficacy of neural modulation therapy

ALSO PUBLISHED AS: 20070162086

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Abstract

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A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CYBERONICS, INC.HOUSTON, TX168

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DiLorenzo, Daniel John New Orleans, LA 47 2140

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MEDTRONIC, INC. (53)
5,031,618 Position-responsive neuro stimulator 210 1990
5,342,409 Position-responsive neuro stimulator 372 1991
5,300,094 Servo muscle control 70 1992
6,249,703 Handheld patient programmer for implantable human tissue stimulator 123 1994
5,683,422 Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation 193 1996
5,716,377 Method of treating movement disorders by brain stimulation 256 1996
6,094,598 Method of treating movement disorders by brain stimulation and drug infusion 162 1996
5,711,316 Method of treating movement disorders by brain infusion 229 1996
5,735,814 Techniques of treating neurodegenerative disorders by brain infusion 119 1996
5,713,923 Techniques for treating epilepsy by brain stimulation and drug infusion 215 1996
5,782,798 Techniques for treating eating disorders by brain stimulation and drug infusion 170 1996
5,752,979 Method of controlling epilepsy by brain stimulation 123 1996
5,800,474 Method of controlling epilepsy by brain stimulation 97 1996
5,957,861 Impedance monitor for discerning edema through evaluation of respiratory rate 352 1997
5,792,186 Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation 166 1997
5,832,932 Method of treating movement disorders by brain infusion 177 1997
5,833,709 Method of treating movement disorders by brain stimulation 218 1997
6,042,579 Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain 111 1997
5,975,085 Method of treating schizophrenia by brain stimulation and drug infusion 115 1997
6,128,537 Techniques for treating anxiety by brain stimulation and drug infusion 133 1997
5,824,021 Method and apparatus for providing feedback to spinal cord stimulation for angina 172 1997
5,814,014 Techniques of treating neurodegenerative disorders by brain infusion 120 1997
5,941,906 Implantable, modular tissue stimulator 283 1997
5,978,702 Techniques of treating epilepsy by brain stimulation and drug infusion 189 1997
6,018,682 Implantable seizure warning system 202 1998
6,374,140 Method and apparatus for treating seizure disorders by stimulating the olfactory senses 108 1998
6,227,203 Techniques for controlling abnormal involuntary movements by brain stimulation and drug infusion 111 1998
6,109,269 Method of treating addiction by brain infusion 94 1999
6,176,242 Method of treating manic depression by brain infusion 115 1999
6,356,784 Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus 148 1999
6,386,882 Remote delivery of software-based training for implantable medical device systems 99 1999
6,337,997 Implantable seizure warning system 147 1999
6,471,645 Communications system for an implantable device and a drug dispenser 183 1999
6,263,237 Techniques for treating anxiety disorders by brain stimulation and drug infusion 117 2000
6,453,198 Power management for an implantable medical device 100 2000
6,687,538 Trial neuro stimulator with lead diagnostics 149 2000
6,443,891 Telemetry modulation protocol system for medical devices 151 2000
6,571,125 Drug delivery device 123 2001
6,671,555 Closed loop neuromodulation for suppression of epileptic activity 126 2001
6,923,784 Therapeutic treatment of disorders based on timing information 104 2001
6,901,292 Control of externally induced current in an implantable pulse generator 61 2001
6,937,891 Independent therapy programs in an implantable medical device 31 2002
6,950,706 Wave shaping for an implantable medical device 32 2002
6,912,419 Method and device for electronically controlling the beating of a heart 80 2003
2004/0077,995 Communications system for an implantable medical device and a delivery device 91 2003
2004/0133,119 Scoring of sensed neurological signals for use with a medical device system 101 2003
2004/0138,516 Configuring and testing treatment therapy parameters for a medical device system 97 2003
2004/0138,517 Multi-modal operation of a medical device system 128 2003
2004/0138,647 Cycle mode providing redundant back-up to ensure termination of treatment therapy in a medical device system 88 2003
2004/0138,711 Control of treatment therapy during start-up and during operation of a medical device system 93 2003
2004/0158,119 Screening techniques for management of a nervous system disorder 137 2003
2005/0113,885 Patient notification of medical device telemetry session 36 2003
2005/0182,464 Methods and apparatus for securing a therapy delivery device within a burr hole 30 2005
 
CYBERONICS, INC. (45)
4,979,511 Strain relief tether for implantable electrode 192 1989
5,154,172 Constant current sources with programmable voltage source 216 1989
5,188,104 Treatment of eating disorders by nerve stimulation 454 1991
5,269,303 Treatment of dementia by nerve stimulation 346 1991
5,215,086 Therapeutic treatment of migraine symptoms by stimulation 413 1991
5,251,634 Helical nerve electrode 208 1991
5,299,569 Treatment of neuropsychiatric disorders by nerve stimulation 498 1991
5,335,657 Therapeutic treatment of sleep disorder by nerve stimulation 605 1991
5,205,285 Voice suppression of vagal stimulation 210 1991
5,222,494 Implantable tissue stimulator output stabilization system 191 1991
5,231,988 Treatment of endocrine disorders by nerve stimulation 423 1991
5,215,089 Electrode assembly for nerve stimulation 198 1991
5,304,206 Activation techniques for implantable medical device 364 1991
5,237,991 Implantable medical device with dummy load for pre-implant testing in sterile package and facilitating electrical lead connection 131 1991
5,179,950 Implanted apparatus having micro processor controlled current and voltage sources with reduced voltage levels when not providing stimulation 173 1991
5,186,170 Simultaneous radio frequency and magnetic field microprocessor reset circuit 158 1991
5,235,980 Implanted apparatus disabling switching regulator operation to allow radio frequency signal reception 155 1991
5,330,515 Treatment of pain by vagal afferent stimulation 366 1992
5,263,480 Treatment of eating disorders by nerve stimulation 402 1992
5,351,394 Method of making a nerve electrode array 194 1992
5,531,778 Circumneural electrode assembly 230 1994
5,571,150 Treatment of patients in coma by nerve stimulation 346 1994
5,540,730 Treatment of motility disorders by nerve stimulation 507 1995
5,707,400 Treating refractory hypertension by nerve stimulation 470 1995
5,928,272 Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity 357 1998
6,366,813 Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease 346 1999
6,587,719 Treatment of obesity by bilateral vagus nerve stimulation 267 1999
6,473,644 Method to enhance cardiac capillary growth in heart failure patients 344 1999
6,609,025 Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation 241 2001
6,622,038 Treatment of movement disorders by near-diaphragmatic nerve stimulation 158 2001
6,622,047 Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation 162 2001
6,600,956 Circumneural electrode assembly 251 2001
6,622,041 Treatment of congestive heart failure and autonomic cardiovascular drive disorders 328 2001
7,231,254 Closed-loop feedback-driven neuromodulation 150 2004
2006/0293,720 Closed-loop feedback-driven neuromodulation 122 2005
2006/0224,191 Systems and methods for monitoring a patient's neurological disease state 85 2005
2007/0142,862 Systems and methods for monitoring a patient's neurological disease state 77 2005
2007/0149,952 Systems and methods for characterizing a patient's propensity for a neurological event and for communicating with a pharmacological agent dispenser 33 2005
2007/0150,024 Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders 67 2005
2007/0150,025 Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders 71 2005
2007/0073,355 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 123 2006
2008/0161,712 Low Power Device With Contingent Scheduling 50 2006
2008/0161,713 Low Power Device With Variable Scheduling 51 2006
2007/0161,919 Methods and systems for continuous EEG monitoring 88 2006
2007/0167,991 Methods and systems for determining subject-specific parameters for a neuromodulation therapy 72 2006
 
NEUROPACE, INC. (30)
6,016,449 System for treatment of neurological disorders 473 1997
6,061,593 EEG d-c voltage shift as a means for detecting the onset of a neurological event 228 1998
5,938,689 Electrode configuration for a brain neuropacemaker 135 1998
6,006,124 Means and method for the placement of brain electrodes 188 1998
6,161,045 Method for determining stimulation parameters for the treatment of epileptic seizures 133 1999
6,230,049 Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes 159 1999
6,128,538 Means and method for the treatment of neurological disorders 245 1999
6,134,474 Responsive implantable system for the treatment of neurological disorders 260 2000
6,473,639 Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures 228 2000
6,466,822 Multimodal neurostimulator and process of using it 229 2000
6,427,086 Means and method for the intracranial placement of a neurostimulator 210 2000
6,353,754 System for the creation of patient specific templates for epileptiform activity detection 144 2000
6,354,299 Implantable device for patient communication 189 2000
6,360,122 Data recording methods for an implantable device 236 2000
6,591,138 Low frequency neurostimulator for the treatment of neurological disorders 162 2000
7,089,059 Predicting susceptibility to neurological dysfunction based on measured neural electrophysiology 130 2000
6,529,774 Extradural leads, neurostimulator assemblies, and processes of using them for somatosensory and brain stimulation 161 2000
6,591,137 Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders 188 2000
6,597,954 System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes 230 2000
6,618,623 Ferrule for cranial implant 78 2000
6,480,743 System and method for adaptive brain stimulation 336 2001
2003/0144,711 Systems and methods for interacting with an implantable medical device 123 2002
2002/0099,412 Methods for using an implantable device for patient communication 170 2002
2002/0169,485 Differential neurostimulation therapy driven by physiological context 239 2002
2003/0195,588 External ear canal interface for the treatment of neurological disorders 133 2002
2003/0028,072 Low frequency magnetic neurostimulator for the treatment of neurological disorders 76 2002
2004/0153,129 System and method for controlling neurological disorders with spatially separated detection and therapy locations 100 2003
2005/0222,641 Neurostimulator involving stimulation strategies and process for using it 29 2005
* 2006/0212,092 Systems and methods for interacting with an implantable medical device 26 2006
2006/0212,093 Differential neurostimulation therapy driven by physiological therapy 26 2006
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (12)
6,051,017 Implantable microstimulator and systems employing the same 375 1998
6,782,292 System and method for treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion 127 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2004/0172,089 FULLY IMPLANTABLE MINIATURE NEUROSTIMULATOR FOR STIMULATION AS A THERAPY FOR EPILEPSY 108 2002
7,177,701 System for permanent electrode placement utilizing microelectrode recording methods 40 2003
 
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (9)
4,991,582 Hermetically sealed ceramic and metal package for electronic devices implantable in living bodies 211 1989
5,312,439 Implantable device having an electrolytic storage electrode 281 1991
5,193,539 Implantable microstimulator 504 1991
5,193,540 Structure and method of manufacture of an implantable microstimulator 491 1991
5,324,316 Implantable microstimulator 370 1993
5,405,367 Structure and method of manufacture of an implantable microstimulator 334 1993
5,571,148 Implantable multichannel stimulator 221 1994
2003/0167,078 Pulsed magnetic control system for interlocking functions of battery powered living tissue stimulators 17 2002
6,990,372 Programmable signal analysis device for detecting neurological signals in an implantable device 59 2002
 
ADVANCED NEUROMODULATION SYSTEMS, INC. (6)
4,612,934 Non-invasive multiprogrammable tissue stimulator 273 1984
4,793,353 Non-invasive multiprogrammable tissue stimulator and method 254 1986
7,010,351 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 105 2001
2004/0181,263 System and method for treating Parkinson's Disease and other movement disorders 84 2003
6,973,342 Flexible bio-probe assembly 89 2004
2005/0021,105 Methods and apparatus for effectuating a change in a neural-function of a patient 88 2004
 
Cardiac Pacemakers, Inc. (6)
5,342,408 Telemetry system for an implantable cardiac device 249 1993
5,876,424 Ultra-thin hermetic enclosure for implantable medical devices 42 1997
2005/0043,772 Therapy triggered by prediction of disordered breathing 112 2003
2005/0187,789 Advanced patient and medication therapy management system and method 78 2004
2005/0137,640 Adaptive safety pacing 25 2004
2005/0182,308 System and method for determining a reference baseline record 40 2005
 
CIT GROUP/BUSINESS CREDIT, INC. (5)
4,702,254 Neurocybernetic prosthesis 412 1985
4,867,164 Neurocybernetic prosthesis 378 1987
5,025,807 Neurocybernetic prosthesis 336 1989
5,540,734 Cranial nerve stimulation treatments using neurocybernetic prosthesis 448 1994
5,700,282 Heart rhythm stabilization using a neurocybernetic prosthesis 400 1995
 
MORGAN STANLEY SENIOR FUNDING, INC., AS AGENT (5)
2004/0133,696 Media role management in a video conferencing network 1 2003
2004/0133,696 Media role management in a video conferencing network 1 2003
2004/0133,696 Media role management in a video conferencing network 1 2003
2004/0133,696 Media role management in a video conferencing network 1 2003
2004/0133,696 Media role management in a video conferencing network 1 2003
 
NEURO AND CARDIAC TECHNOLOGIES, LLC (5)
6,366,814 External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders 241 2000
6,668,191 Apparatus and method for electrical stimulation adjunct (add-on) therapy of atrial fibrillation, inappropriate sinus tachycardia, and refractory hypertension with an external stimulator 168 2001
6,760,626 Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system 163 2001
6,879,859 External pulse generator for adjunct (add-on) treatment of obesity, eating disorders, neurological, neuropsychiatric, and urological disorders 120 2002
2005/0143,787 Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator 163 2005
 
Somatics, Inc. (5)
4,873,981 Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures 40 1988
4,878,498 Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures 39 1989
5,269,302 Electroconvulsive therapy apparatus and method for monitoring patient seizures 79 1992
5,769,778 Medical magnetic non-convulsive stimulation therapy 121 1997
6,117,066 Prevention of seizure arising from medical magnetoictal non-convulsive stimulation therapy 68 1998
 
CHILDREN'S MEDICAL CENTER CORPORATION (4)
4,407,299 Brain electrical activity mapping 51 1981
4,408,616 Brain electricaL activity mapping 47 1981
4,421,122 Brain electrical activity mapping 62 1981
RE34015 Brain electrical activity mapping 81 1987
 
FLINT HILLS SCIENTIFIC, LLC (4)
6,341,236 Vagal nerve stimulation techniques for treatment of epileptic seizures 411 1999
6,560,486 Bi-directional cerebral interface system 108 1999
6,768,969 Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes 91 2001
6,934,580 Stimulation methodologies and apparatus for control of brain states 136 2003
 
The Johns Hopkins University (4)
4,494,950 Plural module medication delivery system 797 1982
5,311,876 Automatic detection of seizures using electroencephalographic signals 139 1992
6,248,126 Technique for using heat flow management to treat brain disorders 105 1999
2005/0149,123 Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders 43 2005
 
Biotronik Mess-und Therapiegeraete GmbH & Co. (3)
5,913,881 Metallic housing for implant with recesses for eddy current reduction 35 1997
6,553,262 Arrangement for patient monitoring 53 1999
6,893,395 Method and apparatus for data transmission between an electromedical implant and an external apparatus 53 2000
 
Lockheed Martin Energy Systems, Inc. (3)
5,626,145 Method and apparatus for extraction of low-frequency artifacts from brain waves for alertness detection 65 1996
5,743,860 Apparatus and method for epileptic seizure detection using non-linear techniques 100 1996
5,857,978 Epileptic seizure prediction by non-linear methods 92 1996
 
MASSACHUSETTS EYE & EAR INFIRMARY (3)
5,411,540 Method and apparatus for preferential neuron stimulation 152 1993
5,476,494 Low pressure neural contact structure 65 1994
5,575,813 Low-pressure neural contact structure 105 1995
 
NEW YORK UNIVERSITY (3)
4,279,258 Rapid automatic electroencephalographic evaluation 87 1980
4,545,388 Self-normed brain state monitoring 36 1983
6,052,619 Brain function scan system 108 1997
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (3)
5,343,064 Fully integrated single-crystal silicon-on-insulator process, sensors and circuits 161 1988
5,314,458 Single channel microstimulator 174 1993
2006/0200,038 Noninvasive nonlinear systems and methods for predicting seizure 17 2003
 
ALLERGAN, INC. (2)
6,620,415 Parkinson's disease treatment 73 2001
6,921,538 Therapeutic treatments for neuropsychiatric disorders 27 2002
 
BIOFIELD CORP. (2)
5,697,369 Method and apparatus for disease, injury and bodily condition screening or sensing 58 1994
5,715,821 Neural network method and apparatus for disease, injury and bodily condition screening or sensing 45 1995
 
CARDIAC INTELLIGENCE CORP. (2)
6,221,011 System and method for determining a reference baseline of individual patient status for use in an automated collection and analysis patient care system 304 1999
6,358,203 System and method for automated collection and analysis of patient information retrieved from an implantable medical device for remote patient care 244 2001
 
CEDARS-SINAI MEDICAL CENTER (2)
6,328,699 Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure 208 2000
2004/0147,969 System for detecting, diagnosing, and treating cardiovascular disease 167 2003
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (2)
6,442,421 METHOD FOR THE MEDICAL MONITORING IN REAL TIME OF A PATIENT FROM THE ANALYSIS OF ELECTROENCEPHALOGRAMS TO CHARACTERIZE AND DIFFERENTIATE BETWEEN PHYSIOLOGICAL OR PATHOLOGICAL CONDITIONS, AND A METHOD FOR ANTICIPATING EPILEPTIC SEIZURES 43 2000
2006/0015,034 Analysis method and real time medical or cognitive monitoring device based on the analysis of a subject's cerebral electromagnetic use of said method for characterizing and differenting physiological and pathological states 23 2003
 
DUKE UNIVERSITY (2)
5,626,627 Electroconvulsive therapy method using ICTAL EEG data as an indicator of ECT seizure adequacy 30 1995
2003/0083,716 Intelligent brain pacemaker for real-time monitoring and controlling of epileptic seizures 99 2001
 
LOCKHEED MARTIN ENERGY RESEARCH CORPORATION (2)
5,815,413 Integrated method for chaotic time series analysis 40 1997
6,484,132 Condition assessment of nonlinear processes 106 2000
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
4,955,380 Flexible measurement probes 51 1988
7,212,851 Microstructured arrays for cortex interaction and related methods of manufacture and use 36 2002
 
MEDPOINTE HEALTHCARE INC. (2)
4,978,680 Method for the prevention and control of epileptic seizure 31 1989
5,082,861 Method for the prevention and control of epileptic seizure associated with complex partial seizures 29 1990
 
NATUS MEDICAL INCORPORATED (2)
6,591,132 Artifact detection in encephalogram data using an event model 24 2001
6,931,274 Processing EEG signals to predict brain damage 42 2002
 
PACESETTER, INC. (2)
2005/0033,369 Data Feedback loop for medical therapy adjustment 24 2003
7,174,212 Implantable medical device having a casing providing high-speed telemetry 18 2003
 
PURDUE RESEARCH FOUNDATION (2)
5,690,681 Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation 286 1996
5,916,239 Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation 356 1997
 
SAM TECHNOLOGY, INC. (2)
5,513,649 Adaptive interference canceler for EEG movement and eye artifacts 68 1994
6,434,419 Neurocognitive ability EEG measurement method and system 72 2000
 
THE CLEVELAND CLINIC FOUNDATION (2)
2005/0049,649 Electrical stimulation of the brain 30 2003
2005/0010,261 Application of stimulus to white matter to induce a desired physiological response 27 2004
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (2)
4,838,272 Method and apparatus for adaptive closed loop electrical stimulation of muscles 57 1987
5,269,315 Determining the nature of brain lesions by electroencephalography 37 1991
 
UNIVERSITY OF KANSAS (2)
5,995,868 System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 321 1997
6,549,804 System for the prediction, rapid detection, warning, prevention or control of changes in activity states in the brain of a subject 188 1999
 
UNIVERSITY OF UTAH (2)
5,215,088 Three-dimensional electrode device 255 1989
5,361,760 Impact inserter mechanism for implantation of a biomedical device 47 1993
 
VAN DEN TOORN, RICK, MR (2)
4,768,176 Apparatus for alerting a patient to take medication 104 1984
4,768,177 Method of and apparatus for alerting a patient to take medication 103 1987
 
3M INNOVATIVE PROPERTIES COMPANY (1)
5,776,434 Medicinal aerosol formulations 48 1997
 
AD-TECH MEDICAL INSTRUMENT CORP. (1)
5,097,835 Subdural electrode with improved lead connection 41 1990
 
ADAMAS PHARMACEUTICALS, INC. (1)
2005/0209,218 Methods and compositions for the treatment of psychiatric conditions 40 2005
 
ADVANCED BIONICS, LLC (1)
6,411,854 Implanted ceramic case with enhanced ceramic case strength 26 1999
 
ADVANCED BRAIN MONITORING, INC. (1)
6,496,724 Method for the quantification of human alertness 49 1999
 
AEQUITRON MEDICAL, INC. (1)
4,579,125 Real-time EEG spectral analyzer 66 1984
 
ANGEL MEDICAL SYSTEMS, INC. (1)
2004/0199,212 External patient alerting system for implantable devices 96 2003
 
APREX CORPORATION (1)
5,917,429 Contactless communication system 68 1996
 
ASPECT MEDICAL SYSTEMS, INC. (1)
5,010,891 Cerebral biopotential analysis system and method 84 1989
 
Beekley Corporation (1)
2004/0243,146 Method and apparatus for supporting a medical device 41 2003
 
BETH ISRAEL DEACONESS MEDICAL CENTER (1)
6,571,123 Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation 64 2000
 
BETH ISRAEL HOSPITAL ASSOCIATION A NON-PROFIT CORPORATION OF MA (1)
5,222,503 Ambulatory electroencephalography system 57 1991
 
BIO CONTROL MEDICAL (B.C.M.) LTD. (1)
6,684,105 Treatment of disorders by unidirectional nerve stimulation 261 2001
 
BIO NEURONICS CORPORATION (1)
2008/0114,417 Systems and methods of reducing artifact in neurological stimulation systems 52 2006
 
Biomed Concepts, Inc. (1)
4,590,946 Surgically implantable electrode for nerve bundles 197 1984
 
BIOMET MICROFIXATION, LLC (1)
5,578,036 Method and apparatus for fixation of bone during surgical procedures 79 1993
 
BIOMETIX PTY. LTD. (1)
2003/0174,554 Security container for medicines and system for filing prescriptions 19 2003
 
Bionova Technologies Inc. (1)
7,373,198 Method and apparatus for the estimation of anesthetic depth using wavelet analysis of the electroencephalogram 22 2003
 
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (1)
6,547,746 Method and apparatus for determining response thresholds 55 2001
 
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY, ACTING THROUGH LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER (1)
2006/0173,510 Medical devices for the detection, prevention and/or treatment of neurological disorders, and methods related thereto 61 2005
 
BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (1)
6,339,725 Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation 133 2000
 
CASE WESTERN RESERVE UNIVERSITY (1)
5,167,229 Functional neuromuscular stimulation system 132 1986
 
CENTER FOR INNOVATIVE TECHNOLOGY, THE (1)
5,190,029 Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content 129 1991
 
Circadian Technologies, Inc. (1)
6,511,424 Method of and apparatus for evaluation and mitigation of microsleep events 57 2000
 
CNS Response (1)
6,622,036 Method for classifying and treating physiologic brain imbalances using quantitative EEG 84 2000
 
COCHLEAR CORPORATION (1)
4,785,827 Subcutaneous housing assembly 42 1987
 
CONSOLIDATED RESEARCH OF RICHMOND, INC. (1)
5,813,993 Alertness and drowsiness detection and tracking system 107 1996
 
CVRX, INC. (1)
2005/0096,710 Baroreceptor activation for epilepsy control 73 2004
 
DEVICE DEVELOPMENTS, INC. (1)
4,566,464 Implantable epilepsy monitor apparatus 87 1981
 
DILORENZO BIOMEDICAL, LLC (1)
2003/0018,367 Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease 193 2002
 
EMORY UNIVERSITY (1)
6,171,239 Systems, methods, and devices for controlling external devices by signals derived directly from the nervous system 162 1998
 
EnteroMedics Inc. (1)
2005/0070,970 Movement disorder stimulation with neural block 66 2004
 
EURO-CELTIQUE S.A. (1)
6,921,541 Formulations and methods for providing prolonged local anesthesia 50 2002
 
FIRST FIDELTY BANK, NATIONAL ASSOCIATION PATTERSON, LINDA L. TRUSTEES (1)
4,679,144 Cardiac signal real time monitor and method of analysis 157 1984
 
GEORGE MASON UNIVERSITY (1)
6,665,562 Adaptive electric field modulation of neural systems 97 2000
 
GEORGIA TECH RESEARCH CORPORATION (1)
6,658,287 Method and apparatus for predicting the onset of seizures based on features derived from signals indicative of brain activity 106 2001
 
Glaxo Inc. (1)
5,376,359 Method of stabilizing aerosol formulations 122 1992
 
GLOBAL SUN TECHNOLOGY INC. (1)
2005/0059,867 Method for monitoring temperature of patient 31 2003
 
Hamit-Darwin-Fresh, Inc. (1)
6,309,406 Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening 30 1999
 
HEALTH RESEARCH, INC. (1)
5,638,826 Communication method and system using brain waves for multidimensional control 74 1995
 
HEMPELMAN, PHILIP (1)
5,070,873 Method of and apparatus for electrically stimulating quadriceps muscles of an upper motor unit paraplegic 57 1987
 
Huntington Institute of Applied Research (1)
4,573,481 Implantable electrode array 402 1984
 
HUNTINGTON MEDICAL RESEARCH INSTITUTES (1)
4,920,979 Bidirectional helical electrode for nerve stimulation 159 1988
 
INTELLIPATCH, INC. (1)
2003/0144,829 System and method for sensing and evaluating physiological parameters and modeling an adaptable predictive analysis for symptoms management 65 2003
 
INTERMEDICS, INC. (1)
5,978,710 Implantable cardiac stimulator with safe noise mode 140 1998
 
IPXMEDICAL, LLC (1)
6,534,693 Surgically implanted devices having reduced scar tissue formation 67 2001
 
JORDAN NEUROSCIENCE, INC. (1)
6,510,340 Method and apparatus for electroencephalography 54 2001
 
JPMORGAN CHASE BANK, N.A. (1)
2002/0062,071 Manual and automatic probe calibration 6 2001
 
KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (1)
4,471,786 Telemetering intracranial pressure transducer 97 1982
 
LEVEN, SAMUEL J. (1)
5,392,788 Method and device for interpreting concepts and conceptual thought from brainwave data and for assisting for diagnosis of brainwave disfunction 72 1993
 
LIFELINE SYSTEMS COMPANY (1)
5,971,594 Medication dispensing system 98 1998
 
LIFEWATCH TECHNOLOGIES, INC. (1)
5,931,791 Medical patient vital signs-monitoring apparatus 256 1997
 
LUCENT TECHNOLOGIES INC. (1)
5,649,068 Pattern recognition system using support vectors 101 1996
 
LUMOS LABS, INC. (1)
6,280,198 Remote computer implemented methods for cognitive testing 68 1999
 
Mayo Foundation for Medical Education and Research Image -Guided Neurologics, Inc. (1)
2007/0250,077 DEVICE FOR IMMOBILIZING A PRIMARY INSTRUMENT AND METHOD THEREFOR 17 2007
 
MED-EL ELEKTROMEDIZINISCHE GERAETE GMBH (1)
6,358,281 Totally implantable cochlear prosthesis 143 1999
 
MEDA PHARMACEUTICALS INC. (1)
5,292,772 Method for the prevention and control of epileptic seizure associated with Lennox-Gastaut syndrome 28 1992
 
MEDSERV GROUP, INC. (1)
5,549,656 Combination neuromuscular stimulator and electromyograph system 158 1995
 
MEDTRONIC TRANSNEURONIX, INC. (1)
2005/0027,328 Minimally invasive surgery placement of stimulation leads in mediastinal structures 30 2004
 
NELLCOR PURITAN BENNETT LLC (1)
5,458,117 Cerebral biopotential analysis system and method 82 1994
 
NEURALIEVE, INC. (1)
6,402,678 Means and method for the treatment of migraine headaches 110 2000
 
NEUROKINETIC APS C/O OSTJYDSK INNOVATION A/S (1)
6,343,226 Multifunction electrode for neural tissue stimulation 114 1999
 
NEUROMEDICS TECHNOLOGY, INC. (1)
5,365,939 Method for evaluating and treating an individual with electroencephalographic disentrainment feedback 51 1993
 
Neurospace, Inc. (1)
6,944,501 Neurostimulator involving stimulation strategies and process for using it 139 2000
 
NEUROTECH S.A. (1)
5,474,547 Implanting devices for the focal release of neuroinhibitory compounds 84 1993
 
NEUROVISTA CORPORATION (1)
2010/0023,089 Controlling a Subject's Susceptibility to a Seizure 16 2009
 
PACESETTER AB (1)
5,405,365 Implantable medical device having means for stimulating tissue contractions with adjustable stimulation intensity and a method for the operation of such a device 32 1994
 
Pain Suppression Labs, Inc. (1)
4,844,075 Transcranial stimulation for the treatment of cerebral palsy 89 1986
 
PERSYST DEVELOPMENT CORPORATION (1)
6,735,467 Method and system for detecting seizures using electroencephalograms 27 2002
 
RDM Consultants Ltd. (1)
5,816,247 Monitoring an EEG 45 1996
 
REMON MEDICAL TECHNOLOGIES LTD. (1)
5,704,352 Implantable passive bio-sensor 205 1995
 
ROYAL POSTGRADUATE MEDICAL SCHOOL (1)
5,181,520 Method and apparatus for analyzing an electro-encephalogram 27 1990
 
SIGMEDICS, INC. (1)
5,016,635 Control of FNS via pattern variations of response EMG 47 1988
 
THE MCLEAN HOSPITAL CORPORATION (1)
6,572,528 Magnetic field stimulation techniques 60 2001
 
The Penn State Research Foundation (1)
2002/0035,338 Epileptic seizure detection and prediction by self-similar methods 19 2000
 
The Trustees of Columbia University in the City of New York (1)
5,555,191 Automated statistical tracker 84 1994
 
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (1)
6,678,548 Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device 50 2000
 
TOTTS GAP MEDICAL RESEARCH LABORATORIES, INC. (1)
5,720,294 PD2I electrophysiological analyzer 44 1996
 
TRILOBOT, INC. (1)
6,042,548 Virtual neurological monitor and method 79 1997
 
Universal Hedonics (1)
6,488,617 Method and device for producing a desired brain state 88 2000
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
6,304,775 Seizure warning and prediction 129 1999
 
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (1)
2004/0176,359 Intranasal Benzodiazepine compositions 21 2004
 
UNIVERSITY OF WASHINGTON (1)
5,349,962 Method and apparatus for detecting epileptic seizures 63 1993
 
VITATRON MEDICAL, B.V. (1)
5,293,879 System an method for detecting tremors such as those which result from parkinson's disease 82 1991
 
WILLIAM REBER, L.L.C. (1)
5,950,632 Medical communication apparatus, system, and method 234 1997
 
Zealear; David L. (1)
4,817,628 System and method for evaluating neurological function controlling muscular movements 104 1985
 
Other [Check patent profile for assignment information] (22)
4,505,275 Treatment method and instrumentation system 40 1982
4,852,573 Implantable neural electrode 338 1987
4,926,865 Microcomputer-based nerve and muscle stimulator 189 1989
5,265,619 Process and device for measuring vibrations, in particular nervous trembling in living organisms 36 1991
5,486,999 Apparatus and method for categorizing health care utilization 109 1994
6,066,163 Adaptive brain stimulation method and system 338 1996
5,611,350 Method and apparatus for facilitating recovery of patients in deep coma 175 1996
5,782,874 Method and apparatus for manipulating nervous systems 54 1997
5,899,922 Manipulation of nervous systems by electric fields 39 1997
6,081,744 Electric fringe field generator for manipulating nervous systems 31 1998
6,205,359 Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator 249 1998
6,167,304 Pulse variability in electric field manipulation of nervous systems 67 1999
6,463,328 Adaptive brain stimulation method and system 370 2000
6,356,788 APPARATUS AND METHOD FOR ADJUNCT (ADD-ON) THERAPY FOR DEPRESSION, MIGRAINE, NEUROPSYCHIATRIC DISORDERS, PARTIAL COMPLEX EPILEPSY, GENERALIZED EPILEPSY AND INVOLUNTARY MOVEMENT DISORDERS UTILIZING AN EXTERNAL STIMULATOR 125 2000
2002/0002,390 Implantable neurostimulator having a data communication link 76 2001
6,778,854 Methods of indirectly stimulating the vagus nerve with an electrical field 112 2002
2005/0197,590 System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 127 2002
2003/0176,806 Method and system for an intelligent supervisory control system 29 2003
2004/0073,273 Adaptive electric field modulation of neural systems 64 2003
2006/0142,822 Externally activated neuro-implant which directly transmits therapeutic signals 24 2003
2005/0124,863 Drug profiling apparatus and method 20 2004
2005/0228,461 Stimulation methodologies and apparatus for control of brain states 25 2005
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
NEUROPACE, INC. (6)
8,073,544 Neurostimulator involving stimulation strategies and process for using it 1 2005
8,412,333 Neurostimulator involving stimulation strategies and process for using it 0 2011
8,326,417 Neurostimulator involving stimulation strategies and process for using it 0 2011
8,224,452 Differential neurostimulation therapy driven by physiological therapy 0 2011
8,423,145 Differential neurostimulation therapy driven by physiological therapy 0 2012
8,694,106 Neurostimulator involving stimulation strategies and process for using it 0 2013
 
CYBERONICS, INC. (4)
8,849,390 Processing for multi-channel signals 0 2009
8,588,933 Medical lead termination sleeve for implantable medical devices 0 2010
8,786,624 Processing for multi-channel signals 0 2010
8,543,199 Implantable systems and methods for identifying a contra-ictal condition in a subject 0 2011
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (3)
* 8,155,750 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 0 2009
* 8,315,707 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 0 2012
8,660,644 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 0 2012
 
CATHOLIC HEALTHCARE WEST (1)
8,738,126 Synchronization of vagus nerve stimulation with the cardiac cycle of a patient 0 2009
 
FLINT HILLS SCIENTIFIC, LLC (1)
* 8,560,073 System and apparatus for automated quantitative assessment, optimization and logging of the effects of a therapy 1 2010
* Cited By Examiner

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