Monitoring efficacy of neural modulation therapy

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO

7853329

APP PUB NO

20070162086A1

SERIAL NO

11647900

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CYBERONICS, INC.HOUSTON, TX218

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DiLorenzo, Daniel John Seattle, US 36 3504

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (22)
4505275 Treatment method and instrumentation system 56 1982
4852573 Implantable neural electrode 452 1987
4926865 Microcomputer-based nerve and muscle stimulator 227 1989
5265619 Process and device for measuring vibrations, in particular nervous trembling in living organisms 49 1991
5486999 Apparatus and method for categorizing health care utilization 132 1994
6066163 Adaptive brain stimulation method and system 499 1996
5611350 Method and apparatus for facilitating recovery of patients in deep coma 216 1996
5782874 Method and apparatus for manipulating nervous systems 88 1997
5899922 Manipulation of nervous systems by electric fields 79 1997
6081744 Electric fringe field generator for manipulating nervous systems 49 1998
6205359 Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator 332 1998
6167304 Pulse variability in electric field manipulation of nervous systems 81 1999
6463328 Adaptive brain stimulation method and system 509 2000
6356788 APPARATUS AND METHOD FOR ADJUNCT (ADD-ON) THERAPY FOR DEPRESSION, MIGRAINE, NEUROPSYCHIATRIC DISORDERS, PARTIAL COMPLEX EPILEPSY, GENERALIZED EPILEPSY AND INVOLUNTARY MOVEMENT DISORDERS UTILIZING AN EXTERNAL STIMULATOR 173 2000
2002/0002,390 Implantable neurostimulator having a data communication link 101 2001
6778854 Methods of indirectly stimulating the vagus nerve with an electrical field 156 2002
2005/0197,590 System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 170 2002
2003/0176,806 Method and system for an intelligent supervisory control system 42 2003
2004/0073,273 Adaptive electric field modulation of neural systems 98 2003
2006/0142,822 Externally activated neuro-implant which directly transmits therapeutic signals 65 2003
2005/0124,863 Drug profiling apparatus and method 32 2004
2005/0228,461 Stimulation methodologies and apparatus for control of brain states 42 2005
 
Huntington Institute of Applied Research (1)
4573481 Implantable electrode array 552 1984
 
HUNTINGTON MEDICAL RESEARCH INSTITUTES (1)
4920979 Bidirectional helical electrode for nerve stimulation 270 1988
 
Pain Suppression Labs, Inc. (1)
4844075 Transcranial stimulation for the treatment of cerebral palsy 106 1986
 
UNIVERSITY OF UTAH (2)
5215088 Three-dimensional electrode device 341 1989
5361760 Impact inserter mechanism for implantation of a biomedical device 62 1993
 
NEURALIEVE, INC. (1)
6402678 Means and method for the treatment of migraine headaches 149 2000
 
DiLorenzo Biomedical, LLC (1)
2003/0018,367 Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease 271 2002
 
LOCKHEED MARTIN ENERGY RESEARCH CORPORATION (2)
5815413 Integrated method for chaotic time series analysis 52 1997
6484132 Condition assessment of nonlinear processes 144 2000
 
Lockheed Martin Energy Systems, Inc. (3)
5626145 Method and apparatus for extraction of low-frequency artifacts from brain waves for alertness detection 82 1996
5743860 Apparatus and method for epileptic seizure detection using non-linear techniques 127 1996
5857978 Epileptic seizure prediction by non-linear methods 107 1996
 
Health Research, Inc. (1)
5638826 Communication method and system using brain waves for multidimensional control 92 1995
 
ASPECT MEDICAL SYSTEMS, INC. (1)
5010891 Cerebral biopotential analysis system and method 107 1989
 
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (9)
4991582 Hermetically sealed ceramic and metal package for electronic devices implantable in living bodies 275 1989
5312439 Implantable device having an electrolytic storage electrode 344 1991
5193539 Implantable microstimulator 683 1991
5193540 Structure and method of manufacture of an implantable microstimulator 639 1991
5324316 Implantable microstimulator 499 1993
5405367 Structure and method of manufacture of an implantable microstimulator 438 1993
5571148 Implantable multichannel stimulator 281 1994
2003/0167,078 Pulsed magnetic control system for interlocking functions of battery powered living tissue stimulators 28 2002
6990372 Programmable signal analysis device for detecting neurological signals in an implantable device 75 2002
 
MEDPOINTE HEALTHCARE INC. (2)
4978680 Method for the prevention and control of epileptic seizure 43 1989
5082861 Method for the prevention and control of epileptic seizure associated with complex partial seizures 41 1990
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
6304775 Seizure warning and prediction 163 1999
 
Glaxo Inc. (1)
5376359 Method of stabilizing aerosol formulations 138 1992
 
KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (1)
4471786 Telemetering intracranial pressure transducer 112 1982
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (2)
4838272 Method and apparatus for adaptive closed loop electrical stimulation of muscles 77 1987
5269315 Determining the nature of brain lesions by electroencephalography 48 1991
 
INTERMEDICS, INC. (1)
5978710 Implantable cardiac stimulator with safe noise mode 154 1998
 
MEDA PHARMACEUTICALS INC. (1)
5292772 Method for the prevention and control of epileptic seizure associated with Lennox-Gastaut syndrome 39 1992
 
DEVICE DEVELOPMENTS, INC. (1)
4566464 Implantable epilepsy monitor apparatus 105 1981
 
THE CLEVELAND CLINIC FOUNDATION (2)
2005/0049,649 Electrical stimulation of the brain 48 2003
2005/0010,261 Application of stimulus to white matter to induce a desired physiological response 47 2004
 
WASHINGTON UNIVERSITY (1)
5349962 Method and apparatus for detecting epileptic seizures 78 1993
 
CENTER FOR INNOVATIVE TECHNOLOGY, THE (1)
5190029 Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content 145 1991
 
UNIVERSITY OF KANSAS (2)
5995868 System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 383 1997
6549804 System for the prediction, rapid detection, warning, prevention or control of changes in activity states in the brain of a subject 222 1999
 
Circadian Technologies, Inc. (1)
6511424 Method of and apparatus for evaluation and mitigation of microsleep events 81 2000
 
DUKE UNIVERSITY (2)
5626627 Electroconvulsive therapy method using ICTAL EEG data as an indicator of ECT seizure adequacy 43 1995
2003/0083,716 Intelligent brain pacemaker for real-time monitoring and controlling of epileptic seizures 126 2001
 
Somatics, Inc. (5)
4873981 Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures 52 1988
4878498 Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures 53 1989
5269302 Electroconvulsive therapy apparatus and method for monitoring patient seizures 105 1992
5769778 Medical magnetic non-convulsive stimulation therapy 153 1997
6117066 Prevention of seizure arising from medical magnetoictal non-convulsive stimulation therapy 84 1998
 
INTELLIPATCH, INC. (1)
2003/0144,829 System and method for sensing and evaluating physiological parameters and modeling an adaptable predictive analysis for symptoms management 99 2003
 
GLOBAL SUN TECHNOLOGY INC. (1)
2005/0059,867 Method for monitoring temperature of patient 45 2003
 
CNS Response (1)
6622036 Method for classifying and treating physiologic brain imbalances using quantitative EEG 110 2000
 
CYBERONICS, INC. (45)
4979511 Strain relief tether for implantable electrode 278 1989
5154172 Constant current sources with programmable voltage source 279 1989
5188104 Treatment of eating disorders by nerve stimulation 553 1991
5269303 Treatment of dementia by nerve stimulation 471 1991
5215086 Therapeutic treatment of migraine symptoms by stimulation 534 1991
5251634 Helical nerve electrode 331 1991
5299569 Treatment of neuropsychiatric disorders by nerve stimulation 652 1991
5335657 Therapeutic treatment of sleep disorder by nerve stimulation 801 1991
5205285 Voice suppression of vagal stimulation 264 1991
5222494 Implantable tissue stimulator output stabilization system 263 1991
5231988 Treatment of endocrine disorders by nerve stimulation 585 1991
5215089 Electrode assembly for nerve stimulation 253 1991
5304206 Activation techniques for implantable medical device 482 1991
5237991 Implantable medical device with dummy load for pre-implant testing in sterile package and facilitating electrical lead connection 165 1991
5179950 Implanted apparatus having micro processor controlled current and voltage sources with reduced voltage levels when not providing stimulation 226 1991
5186170 Simultaneous radio frequency and magnetic field microprocessor reset circuit 200 1991
5235980 Implanted apparatus disabling switching regulator operation to allow radio frequency signal reception 202 1991
5330515 Treatment of pain by vagal afferent stimulation 479 1992
5263480 Treatment of eating disorders by nerve stimulation 514 1992
5351394 Method of making a nerve electrode array 272 1992
5531778 Circumneural electrode assembly 326 1994
5571150 Treatment of patients in coma by nerve stimulation 447 1994
5540730 Treatment of motility disorders by nerve stimulation 652 1995
5707400 Treating refractory hypertension by nerve stimulation 696 1995
5928272 Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity 483 1998
6366813 Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease 446 1999
6587719 Treatment of obesity by bilateral vagus nerve stimulation 367 1999
6473644 Method to enhance cardiac capillary growth in heart failure patients 466 1999
6609025 Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation 297 2001
6622038 Treatment of movement disorders by near-diaphragmatic nerve stimulation 215 2001
6622047 Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation 215 2001
6600956 Circumneural electrode assembly 420 2001
6622041 Treatment of congestive heart failure and autonomic cardiovascular drive disorders 447 2001
7231254 Closed-loop feedback-driven neuromodulation 242 2004
2006/0293,720 Closed-loop feedback-driven neuromodulation 178 2005
2006/0224,191 Systems and methods for monitoring a patient's neurological disease state 111 2005
2007/0142,862 Systems and methods for monitoring a patient's neurological disease state 97 2005
2007/0149,952 Systems and methods for characterizing a patient's propensity for a neurological event and for communicating with a pharmacological agent dispenser 49 2005
2007/0150,024 Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders 109 2005
2007/0150,025 Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders 110 2005
2007/0073,355 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease 164 2006
2008/0161,712 Low Power Device With Contingent Scheduling 74 2006
2008/0161,713 Low Power Device With Variable Scheduling 80 2006
2007/0161,919 Methods and systems for continuous EEG monitoring 120 2006
2007/0167,991 Methods and systems for determining subject-specific parameters for a neuromodulation therapy 107 2006
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (2)
6442421 METHOD FOR THE MEDICAL MONITORING IN REAL TIME OF A PATIENT FROM THE ANALYSIS OF ELECTROENCEPHALOGRAMS TO CHARACTERIZE AND DIFFERENTIATE BETWEEN PHYSIOLOGICAL OR PATHOLOGICAL CONDITIONS, AND A METHOD FOR ANTICIPATING EPILEPTIC SEIZURES 56 2000
2006/0015,034 Analysis method and real time medical or cognitive monitoring device based on the analysis of a subject's cerebral electromagnetic use of said method for characterizing and differenting physiological and pathological states 35 2003
 
BIOMETIX PTY. LTD. (1)
2003/0174,554 Security container for medicines and system for filing prescriptions 33 2003
 
PURDUE RESEARCH FOUNDATION (2)
5690681 Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation 347 1996
5916239 Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation 495 1997
 
NATUS MEDICAL INCORPORATED (2)
6591132 Artifact detection in encephalogram data using an event model 35 2001
6931274 Processing EEG signals to predict brain damage 61 2002
 
LIFELINE SYSTEMS COMPANY (1)
5971594 Medication dispensing system 119 1998
 
University of Kentucky Research Foundation (1)
2004/0176,359 Intranasal Benzodiazepine compositions 33 2004
 
Persyst Development Corporation (1)
6735467 Method and system for detecting seizures using electroencephalograms 39 2002
 
Vitatron Medical B.V. (1)
5293879 System an method for detecting tremors such as those which result from parkinson's disease 100 1991
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (3)
5343064 Fully integrated single-crystal silicon-on-insulator process, sensors and circuits 182 1988
5314458 Single channel microstimulator 222 1993
2006/0200,038 Noninvasive nonlinear systems and methods for predicting seizure 28 2003
 
3M INNOVATIVE PROPERTIES COMPANY (1)
5776434 Medicinal aerosol formulations 61 1997
 
CONSOLIDATED RESEARCH OF RICHMOND, INC. (1)
5813993 Alertness and drowsiness detection and tracking system 133 1996
 
CEDARS-SINAI MEDICAL CENTER (2)
6328699 Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure 312 2000
2004/0147,969 System for detecting, diagnosing, and treating cardiovascular disease 229 2003
 
BIOTRONIK MESS-UND THERAPIEGERAETE GMBH & CO. INGENIEURBUERO BERLIN (3)
5913881 Metallic housing for implant with recesses for eddy current reduction 48 1997
6553262 Arrangement for patient monitoring 77 1999
6893395 Method and apparatus for data transmission between an electromedical implant and an external apparatus 88 2000
 
SAM Technology, Inc. (2)
5513649 Adaptive interference canceler for EEG movement and eye artifacts 104 1994
6434419 Neurocognitive ability EEG measurement method and system 105 2000
 
Royal Postgraduate Medical School (1)
5181520 Method and apparatus for analyzing an electro-encephalogram 39 1990
 
NEUROMEDICS TECHNOLOGY, INC. (1)
5365939 Method for evaluating and treating an individual with electroencephalographic disentrainment feedback 62 1993
 
THE JOHNS HOPKINS UNIVERSITY (4)
4494950 Plural module medication delivery system 1055 1982
5311876 Automatic detection of seizures using electroencephalographic signals 174 1992
6248126 Technique for using heat flow management to treat brain disorders 175 1999
2005/0149,123 Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders 61 2005
 
LUMOS LABS INC. (1)
6280198 Remote computer implemented methods for cognitive testing 91 1999
 
Beekley Corporation (1)
2004/0243,146 Method and apparatus for supporting a medical device 61 2003
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (12)
6051017 Implantable microstimulator and systems employing the same 523 1998
6782292 System and method for treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion 157 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 16 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 16 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 16 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 16 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 16 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 16 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 16 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 16 2001
2004/0172,089 FULLY IMPLANTABLE MINIATURE NEUROSTIMULATOR FOR STIMULATION AS A THERAPY FOR EPILEPSY 164 2002
7177701 System for permanent electrode placement utilizing microelectrode recording methods 66 2003
 
NEUROKINETIC APS C/O OSTJYDSK INNOVATION A/S (1)
6343226 Multifunction electrode for neural tissue stimulation 160 1999
 
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (1)
6547746 Method and apparatus for determining response thresholds 67 2001
 
ADAMAS PHARMACEUTICALS, INC. (1)
2005/0209,218 Methods and compositions for the treatment of psychiatric conditions 68 2005
 
Biomed Concepts, Inc. (1)
4590946 Surgically implantable electrode for nerve bundles 264 1984
 
NEUROPACE (1)
6016449 System for treatment of neurological disorders 596 1997
 
Advanced Neuromodulation Systems, Inc. (6)
4612934 Non-invasive multiprogrammable tissue stimulator 354 1984
4793353 Non-invasive multiprogrammable tissue stimulator and method 317 1986
7010351 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 152 2001
2004/0181,263 System and method for treating Parkinson's Disease and other movement disorders 104 2003
6973342 Flexible bio-probe assembly 124 2004
2005/0021,105 Methods and apparatus for effectuating a change in a neural-function of a patient 115 2004
 
BETH ISRAEL HOSPITAL ASSOCIATION A NON-PROFIT CORPORATION OF MA (1)
5222503 Ambulatory electroencephalography system 71 1991
 
IPXMEDICAL, LLC (1)
6534693 Surgically implanted devices having reduced scar tissue formation 93 2001
 
HEMPELMAN, PHILIP (1)
5070873 Method of and apparatus for electrically stimulating quadriceps muscles of an upper motor unit paraplegic 84 1987
 
MED-EL ELEKTROMEDIZINISCHE GERAETE GMBH (1)
6358281 Totally implantable cochlear prosthesis 184 1999
 
BIOFIELD CORP. (2)
5697369 Method and apparatus for disease, injury and bodily condition screening or sensing 119 1994
5715821 Neural network method and apparatus for disease, injury and bodily condition screening or sensing 56 1995
 
AEQUITRON MEDICAL, INC. (1)
4579125 Real-time EEG spectral analyzer 85 1984
 
BIO CONTROL MEDICAL (B.C.M.) LTD. (1)
6684105 Treatment of disorders by unidirectional nerve stimulation 360 2001
 
The Trustees of Columbia University in the City of New York (1)
5555191 Automated statistical tracker 117 1994
 
REMON MEDICAL TECHNOLOGIES LTD. (1)
5704352 Implantable passive bio-sensor 247 1995
 
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY, ACTING THROUGH LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER (1)
2006/0173,510 Medical devices for the detection, prevention and/or treatment of neurological disorders, and methods related thereto 125 2005
 
PACESETTER, INC. (2)
2005/0033,369 Data Feedback loop for medical therapy adjustment 36 2003
7174212 Implantable medical device having a casing providing high-speed telemetry 31 2003
 
PACESETTER AB (1)
5405365 Implantable medical device having means for stimulating tissue contractions with adjustable stimulation intensity and a method for the operation of such a device 48 1994
 
TRILOBOT, INC. (1)
6042548 Virtual neurological monitor and method 100 1997
 
Ad-Tech Medical Instrument Corp. (1)
5097835 Subdural electrode with improved lead connection 55 1990
 
TOTTS GAP MEDICAL RESEARCH LABORATORIES, INC. (1)
5720294 PD2I electrophysiological analyzer 57 1996
 
NELLCOR PURITAN BENNETT LLC (1)
5458117 Cerebral biopotential analysis system and method 105 1994
 
MORRA, BRUCE S. (2)
4768176 Apparatus for alerting a patient to take medication 115 1984
4768177 Method of and apparatus for alerting a patient to take medication 115 1987
 
LUCENT TECHNOLOGIES INC. (1)
5649068 Pattern recognition system using support vectors 119 1996
 
Zealear; David L. (1)
4817628 System and method for evaluating neurological function controlling muscular movements 143 1985
 
Hamit-Darwin-Fresh, Inc. (1)
6309406 Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening 46 1999
 
SIGMEDICS, INC. (1)
5016635 Control of FNS via pattern variations of response EMG 73 1988
 
EMORY UNIVERSITY (1)
6171239 Systems, methods, and devices for controlling external devices by signals derived directly from the nervous system 223 1998
 
Cardiac Intelligence Corporation (2)
6221011 System and method for determining a reference baseline of individual patient status for use in an automated collection and analysis patient care system 371 1999
6358203 System and method for automated collection and analysis of patient information retrieved from an implantable medical device for remote patient care 299 2001
 
NEUROVISTA CORPORATION (1)
2010/0023,089 Controlling a Subject's Susceptibility to a Seizure 29 2009
 
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (1)
6678548 Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device 67 2000
 
Cardiac Pacemakers, Inc. (6)
5342408 Telemetry system for an implantable cardiac device 291 1993
5876424 Ultra-thin hermetic enclosure for implantable medical devices 57 1997
2005/0043,772 Therapy triggered by prediction of disordered breathing 154 2003
2005/0187,789 Advanced patient and medication therapy management system and method 120 2004
2005/0137,640 Adaptive safety pacing 37 2004
2005/0182,308 System and method for determining a reference baseline record 66 2005
 
Cochlear Corporation (1)
4785827 Subcutaneous housing assembly 52 1987
 
CIT GROUP/BUSINESS CREDIT, INC. (5)
4702254 Neurocybernetic prosthesis 473 1985
4867164 Neurocybernetic prosthesis 434 1987
5025807 Neurocybernetic prosthesis 394 1989
5540734 Cranial nerve stimulation treatments using neurocybernetic prosthesis 604 1994
5700282 Heart rhythm stabilization using a neurocybernetic prosthesis 541 1995
 
Universal Hedonics (1)
6488617 Method and device for producing a desired brain state 134 2000
 
FIRST FIDELITY BANK, NATIONAL ASSOCIATION, AS AGENT (1)
4679144 Cardiac signal real time monitor and method of analysis 205 1984
 
ALLERGAN, INC. (1)
6620415 Parkinson's disease treatment 100 2001
 
ANGEL MEDICAL SYSTEMS, INC. (1)
2004/0199,212 External patient alerting system for implantable devices 144 2003
 
GEORGIA TECH RESEARCH CORPORATION (1)
6658287 Method and apparatus for predicting the onset of seizures based on features derived from signals indicative of brain activity 134 2001
 
BIO NEURONICS CORPORATION (1)
2008/0114,417 Systems and methods of reducing artifact in neurological stimulation systems 82 2006
 
ALLERGAN SALES, INC. (1)
6921538 Therapeutic treatments for neuropsychiatric disorders 38 2002
 
MORGAN STANLEY SENIOR FUNDING INC., AS THE ADMINISTRATIVE AGENT (5)
2004/0133,696 Media role management in a video conferencing network 4 2003
2004/0133,696 Media role management in a video conferencing network 4 2003
2004/0133,696 Media role management in a video conferencing network 4 2003
2004/0133,696 Media role management in a video conferencing network 4 2003
2004/0133,696 Media role management in a video conferencing network 4 2003
 
MEDTRONIC TRANSNEURONIX, INC. (1)
2005/0027,328 Minimally invasive surgery placement of stimulation leads in mediastinal structures 50 2004
 
The Penn State Research Foundation (1)
2002/0035,338 Epileptic seizure detection and prediction by self-similar methods 30 2000
 
Neurospace, Inc. (1)
6944501 Neurostimulator involving stimulation strategies and process for using it 186 2000
 
BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (1)
6571123 Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation 89 2000
 
WILLIAM REBER, L.L.C. (1)
5950632 Medical communication apparatus, system, and method 292 1997
 
EURO-CELTIQUE S.A. (1)
6921541 Formulations and methods for providing prolonged local anesthesia 98 2002
 
MASSACHUSETTS EYE & EAR INFIRMARY (3)
5411540 Method and apparatus for preferential neuron stimulation 199 1993
5476494 Low pressure neural contact structure 90 1994
5575813 Low-pressure neural contact structure 131 1995
 
LEVEN, SAMUEL J. (1)
5392788 Method and device for interpreting concepts and conceptual thought from brainwave data and for assisting for diagnosis of brainwave disfunction 100 1993
 
NEUROTECH S.A. (1)
5474547 Implanting devices for the focal release of neuroinhibitory compounds 97 1993
 
MEDTRONIC, INC. (53)
5031618 Position-responsive neuro stimulator 263 1990
5342409 Position-responsive neuro stimulator 450 1991
5300094 Servo muscle control 92 1992
6249703 Handheld patient programmer for implantable human tissue stimulator 163 1994
5683422 Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation 241 1996
5716377 Method of treating movement disorders by brain stimulation 346 1996
6094598 Method of treating movement disorders by brain stimulation and drug infusion 208 1996
5711316 Method of treating movement disorders by brain infusion 315 1996
5735814 Techniques of treating neurodegenerative disorders by brain infusion 140 1996
5713923 Techniques for treating epilepsy by brain stimulation and drug infusion 247 1996
5782798 Techniques for treating eating disorders by brain stimulation and drug infusion 207 1996
5752979 Method of controlling epilepsy by brain stimulation 149 1996
5800474 Method of controlling epilepsy by brain stimulation 131 1996
5957861 Impedance monitor for discerning edema through evaluation of respiratory rate 432 1997
5792186 Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation 205 1997
5832932 Method of treating movement disorders by brain infusion 210 1997
5833709 Method of treating movement disorders by brain stimulation 279 1997
6042579 Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain 134 1997
5975085 Method of treating schizophrenia by brain stimulation and drug infusion 151 1997
6128537 Techniques for treating anxiety by brain stimulation and drug infusion 167 1997
5824021 Method and apparatus for providing feedback to spinal cord stimulation for angina 215 1997
5814014 Techniques of treating neurodegenerative disorders by brain infusion 144 1997
5941906 Implantable, modular tissue stimulator 368 1997
5978702 Techniques of treating epilepsy by brain stimulation and drug infusion 227 1997
6018682 Implantable seizure warning system 253 1998
6374140 Method and apparatus for treating seizure disorders by stimulating the olfactory senses 144 1998
6227203 Techniques for controlling abnormal involuntary movements by brain stimulation and drug infusion 141 1998
6109269 Method of treating addiction by brain infusion 124 1999
6176242 Method of treating manic depression by brain infusion 154 1999
6356784 Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus 184 1999
6386882 Remote delivery of software-based training for implantable medical device systems 142 1999
6337997 Implantable seizure warning system 191 1999
6471645 Communications system for an implantable device and a drug dispenser 240 1999
6263237 Techniques for treating anxiety disorders by brain stimulation and drug infusion 139 2000
6453198 Power management for an implantable medical device 134 2000
6687538 Trial neuro stimulator with lead diagnostics 202 2000
6443891 Telemetry modulation protocol system for medical devices 202 2000
6571125 Drug delivery device 174 2001
6671555 Closed loop neuromodulation for suppression of epileptic activity 158 2001
6923784 Therapeutic treatment of disorders based on timing information 168 2001
6901292 Control of externally induced current in an implantable pulse generator 89 2001
6937891 Independent therapy programs in an implantable medical device 60 2002
6950706 Wave shaping for an implantable medical device 65 2002
6912419 Method and device for electronically controlling the beating of a heart 105 2003
2004/0077,995 Communications system for an implantable medical device and a delivery device 138 2003
2004/0133,119 Scoring of sensed neurological signals for use with a medical device system 134 2003
2004/0138,516 Configuring and testing treatment therapy parameters for a medical device system 123 2003
2004/0138,517 Multi-modal operation of a medical device system 179 2003
2004/0138,647 Cycle mode providing redundant back-up to ensure termination of treatment therapy in a medical device system 116 2003
2004/0138,711 Control of treatment therapy during start-up and during operation of a medical device system 123 2003
2004/0158,119 Screening techniques for management of a nervous system disorder 179 2003
2005/0113,885 Patient notification of medical device telemetry session 50 2003
2005/0182,464 Methods and apparatus for securing a therapy delivery device within a burr hole 45 2005
 
NEURO AND CARDIAC TECHNOLOGIES, LLC (5)
6366814 External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders 356 2000
6668191 Apparatus and method for electrical stimulation adjunct (add-on) therapy of atrial fibrillation, inappropriate sinus tachycardia, and refractory hypertension with an external stimulator 221 2001
6760626 Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system 225 2001
6879859 External pulse generator for adjunct (add-on) treatment of obesity, eating disorders, neurological, neuropsychiatric, and urological disorders 168 2002
2005/0143,787 Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator 242 2005
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
4955380 Flexible measurement probes 66 1988
7212851 Microstructured arrays for cortex interaction and related methods of manufacture and use 59 2002
 
NEUROPACE, INC. (29)
6061593 EEG d-c voltage shift as a means for detecting the onset of a neurological event 279 1998
5938689 Electrode configuration for a brain neuropacemaker 160 1998
6006124 Means and method for the placement of brain electrodes 239 1998
6161045 Method for determining stimulation parameters for the treatment of epileptic seizures 185 1999
6230049 Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes 190 1999
6128538 Means and method for the treatment of neurological disorders 302 1999
6134474 Responsive implantable system for the treatment of neurological disorders 342 2000
6473639 Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures 302 2000
6466822 Multimodal neurostimulator and process of using it 280 2000
6427086 Means and method for the intracranial placement of a neurostimulator 258 2000
6353754 System for the creation of patient specific templates for epileptiform activity detection 172 2000
6354299 Implantable device for patient communication 219 2000
6360122 Data recording methods for an implantable device 275 2000
6591138 Low frequency neurostimulator for the treatment of neurological disorders 192 2000
7089059 Predicting susceptibility to neurological dysfunction based on measured neural electrophysiology 181 2000
6529774 Extradural leads, neurostimulator assemblies, and processes of using them for somatosensory and brain stimulation 213 2000
6591137 Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders 234 2000
6597954 System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes 314 2000
6618623 Ferrule for cranial implant 109 2000
6480743 System and method for adaptive brain stimulation 415 2001
2003/0144,711 Systems and methods for interacting with an implantable medical device 155 2002
2002/0099,412 Methods for using an implantable device for patient communication 203 2002
2002/0169,485 Differential neurostimulation therapy driven by physiological context 287 2002
2003/0195,588 External ear canal interface for the treatment of neurological disorders 178 2002
2003/0028,072 Low frequency magnetic neurostimulator for the treatment of neurological disorders 115 2002
2004/0153,129 System and method for controlling neurological disorders with spatially separated detection and therapy locations 134 2003
2005/0222,641 Neurostimulator involving stimulation strategies and process for using it 48 2005
* 2006/0212,092 Systems and methods for interacting with an implantable medical device 41 2006
2006/0212,093 Differential neurostimulation therapy driven by physiological therapy 43 2006
 
FLINT HILLS SCIENTIFIC, L.L.C. (4)
6341236 Vagal nerve stimulation techniques for treatment of epileptic seizures 551 1999
6560486 Bi-directional cerebral interface system 152 1999
6768969 Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes 119 2001
6934580 Stimulation methodologies and apparatus for control of brain states 177 2003
 
JPMORGAN CHASE BANK, N.A. (1)
2002/0062,071 Manual and automatic probe calibration 18 2001
 
NEW YORK UNIVERSITY (3)
4279258 Rapid automatic electroencephalographic evaluation 122 1980
4545388 Self-normed brain state monitoring 48 1983
6052619 Brain function scan system 148 1997
 
ADVANCED BIONICS, LLC (1)
6411854 Implanted ceramic case with enhanced ceramic case strength 38 1999
 
Bionova Technologies Inc. (1)
7373198 Method and apparatus for the estimation of anesthetic depth using wavelet analysis of the electroencephalogram 36 2003
 
Mayo Foundation for Medical Education and Research Image -Guided Neurologics, Inc. (1)
2007/0250,077 DEVICE FOR IMMOBILIZING A PRIMARY INSTRUMENT AND METHOD THEREFOR 40 2007
 
GEORGE MASON UNIVERSITY (1)
6665562 Adaptive electric field modulation of neural systems 120 2000
 
The McLean Hospital Corporation (1)
6572528 Magnetic field stimulation techniques 80 2001
 
CHILDREN'S MEDICAL CENTER CORPORATION (4)
4407299 Brain electrical activity mapping 66 1981
4408616 Brain electricaL activity mapping 62 1981
4421122 Brain electrical activity mapping 76 1981
RE34015 Brain electrical activity mapping 111 1987
 
ZIMMER BIOMET CMF AND THORACIC, LLC (1)
5578036 Method and apparatus for fixation of bone during surgical procedures 105 1993
 
LIFEWATCH TECHNOLOGIES, INC. (1)
5931791 Medical patient vital signs-monitoring apparatus 328 1997
 
CVRX, INC. (1)
2005/0096,710 Baroreceptor activation for epilepsy control 139 2004
 
APREX CORPORATION (1)
5917429 Contactless communication system 87 1996
 
EnteroMedics Inc. (1)
2005/0070,970 Movement disorder stimulation with neural block 88 2004
 
RDM Consultants Ltd. (1)
5816247 Monitoring an EEG 58 1996
 
ADVANCED BRAIN MONITORING, INC. (1)
6496724 Method for the quantification of human alertness 66 1999
 
CASE WESTERN RESERVE UNIVERSITY (1)
5167229 Functional neuromuscular stimulation system 166 1986
 
BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (1)
6339725 Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation 203 2000
 
JORDAN NEUROSCIENCE, INC. (1)
6510340 Method and apparatus for electroencephalography 81 2001
 
MEDSERV GROUP, INC. (1)
5549656 Combination neuromuscular stimulator and electromyograph system 196 1995
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
CYBERONICS, INC. (6)
8849390 Processing for multi-channel signals 0 2009
8588933 Medical lead termination sleeve for implantable medical devices 1 2010
8786624 Processing for multi-channel signals 0 2010
8543199 Implantable systems and methods for identifying a contra-ictal condition in a subject 1 2011
9445730 Implantable systems and methods for identifying a contra-ictal condition in a subject 0 2013
9289595 Medical lead termination sleeve for implantable medical devices 0 2013
 
FLINT HILLS SCIENTIFIC, L.L.C. (2)
* 8560073 System and apparatus for automated quantitative assessment, optimization and logging of the effects of a therapy 1 2010
* 2011/0160,795 SYSTEM AND APPARATUS FOR AUTOMATED QUANTITATIVE ASSESSMENT, OPTIMIZATION AND LOGGING OF THE EFFECTS OF A THERAPY 4 2010
 
NEUROPACE, INC. (8)
8073544 Neurostimulator involving stimulation strategies and process for using it 4 2005
8412333 Neurostimulator involving stimulation strategies and process for using it 0 2011
8326417 Neurostimulator involving stimulation strategies and process for using it 0 2011
8224452 Differential neurostimulation therapy driven by physiological therapy 3 2011
8423145 Differential neurostimulation therapy driven by physiological therapy 4 2012
8694106 Neurostimulator involving stimulation strategies and process for using it 0 2013
8934980 Differential neurostimulation therapy driven by physiological therapy 0 2013
9451891 Differential neurostimulation therapy driven by physiological therapy 0 2014
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (5)
* 8155750 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 11 2009
* 2010/0023,090 SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMODATION TO ELETRICAL STIMULATION 9 2009
* 8315707 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 0 2012
* 2012/0179,222 SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMMODATION TO ELECTRICAL STIMULATION 5 2012
8660644 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 0 2012
 
DIGNITY HEALTH (3)
9289599 Vagus nerve stimulation method 0 2012
9108041 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 0 2013
9533151 Microburst electrical stimulation of cranial nerves for the treatment of medical conditions 0 2014
 
Catholic Healthcare West (1)
8738126 Synchronization of vagus nerve stimulation with the cardiac cycle of a patient 2 2009
* Cited By Examiner

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