Immunization with bacterial ghost-based vaccines
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United States of America Patent
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Dec 28, 2010
Grant Date -
Sep 24, 2009
app pub date -
May 1, 2009
filing date -
Jun 11, 2001
priority date (Note) -
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Abstract
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material.
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