Dehydration/rehydration of derivatized, marker-loaded liposomes on a test device and method of use thereof
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United States of America Patent
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Dec 28, 2010
Grant Date -
Sep 25, 2008
app pub date -
May 28, 2008
filing date -
Jun 23, 1999
priority date (Note) -
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Abstract
The present invention relates to a method for making a test device for detecting or quantifying an analyte in a sample. This method involves contacting a membrane with a mixture including derivatized, marker-loaded liposomes, and substantially dehydrating the mixture on the membrane under vacuum pressure at a temperature of from about 4.degree. C. to about 80.degree. C., wherein said mixture further includes one or more sugars in an amount sufficient to promote the stability of the liposomes during dehydration and rehydration. The present invention also relates to a test device and method for detecting or quantifying an analyte in a sample. The test device includes a membrane which includes an immobilized liposome zone, wherein the immobilized liposome zone has bound thereto dehydrated, derivatized, marker-loaded liposomes dehydrated under vacuum pressure at a temperature of from about 4.degree. C. to about 80.degree. C. from a mixture which includes one or more sugars in an amount sufficient to promote the stability of the liposomes during dehydration and rehydration.
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