Analysis of circulating tumor cells, fragments, and debris

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United States of America Patent

PATENT NO 7863012
APP PUB NO 20050181463A1
SERIAL NO

10780399

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Abstract

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The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.

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Patent Owner(s)

Patent OwnerAddress
MENARINI SILICON BIOSYSTEMS S P A40013 CASTEL MAGGIORE (BO)

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gross, Steven Ambler, US 16 570
Larson, Christopher Media, US 18 209
O'Hara, Shawn Mark Ambler, US 13 297
Rao, Galla Chandra Princeton Junction, US 31 1339
Repollet, Madeline Fort Washington, US 2 147
Rutner, Herman Hatboro, US 18 458
Terstappen, Leon W M M Huntingdon Valley, US 41 2020

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