Insulin-oligomer conjugates, formulations and uses thereof
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United States of America Patent
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Jan 18, 2011
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app pub date -
Jul 19, 2005
filing date -
Jul 19, 2004
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Abstract
An insulin compound coupled to a modifying moiety having a formula: --X--R.sup.1--Y-PAG-Z--R (Formula VI) where, X, Y and Z are independently selected linking groups and each is optionally present, and X, when present, is coupled to the insulin compound by a covalent bond, either R.sup.1 or R.sup.2 is is a lower alkyl, optionally including a carbonyl group, and when R.sup.1 is a lower alkyl, R.sup.2 is a capping group, and PAG is a linear or branched carbon chain incorporating one or more alkalene glycol moieties, and optionally incorporating one or more additional moieties selected from the group consisting of --S--, --O--, --N--, and --C(O)--, and where the modifying moiety has a maximum number of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 heavy atoms.
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