Process for making Biolimus A9
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United States of America Patent
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Jan 18, 2011
Grant Date -
Nov 26, 2009
app pub date -
May 8, 2009
filing date -
May 26, 2008
priority date (Note) -
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Abstract
A process for making Biolimus A9 comprises reacting sirolimus (or rapamycin) with alkyl benzene sulfonate under the catalyzing of organic base and in the presence of organic solvent to undergo a nucleophilic substitution reaction to obtain the Biolimus A9 with high yield, not only for small-scale laboratory experiment, but also for rendering reproducibility of high yield even after process amplification.
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