US Patent No: 7,875,677
Number of patents in Portfolio can not be more than 2000
Micellar drug delivery systems for hydrophobic drugs
Stats
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Jan 25, 2011
Issued date -
Aug 18, 2008
filing date -
12/193,648
serial no -
In Force
status
Importance
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Abstract
This invention provides compositions comprising a hydrophobic drug, a biocompatible micelle forming polymer, and a biocompatible low molecular weight, water-soluble polymer. Also provided are devices for injection of such compositions and for the use of such compositions to form hydrophobic drug containing micelles within the body of a patient.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,248,796 Taxol derivatives | 71 | 1992 | |
| 5,300,638 Asymmetric synthesis of taxol side chain | 28 | 1992 | |
| 5,272,171 Phosphonooxy and carbonate derivatives of taxol | 87 | 1992 | |
| 5,254,580 7,8-cyclopropataxanes | 112 | 1993 | |
| 5,294,637 Fluoro taxols | 64 | 1993 | |
| 5,380,751 6,7-modified paclitaxels | 34 | 1993 | |
| 5,412,092 N-substituted 2-azetidinones | 41 | 1993 | |
| 5,395,850 6,7-epoxy paclitaxels | 19 | 1994 | |
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| 4,814,470 Taxol derivatives, their preparation and pharmaceutical compositions containing them | 221 | 1987 | |
| 5,393,895 Process for obtaining 10-deacetylbaccatin III | 8 | 1993 | |
| 5,393,896 Process for obtaining 10-deacetylbaccatin III | 7 | 1993 | |
| 5,717,103 Process for the esterification of baccatin III and of 10-deacetylbaccatin III | 3 | 1995 | |
| 5,736,366 Process for obtaining 10-deacetylbaccatin III | 6 | 1995 | |
| 5,977,375 Esters of baccatin III and 10-deacetylbaccatin III | 1 | 1997 | |
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| 5,811,447 Therapeutic inhibitor of vascular smooth muscle cells | 170 | 1995 | |
| 5,981,568 Therapeutic inhibitor of vascular smooth muscle cells | 223 | 1997 | |
| 6,306,421 Therapeutic inhibitor of vascular smooth muscle cells | 73 | 1997 | |
| 6,231,600 Stents with hybrid coating for medical devices | 305 | 1999 | |
| 6,358,989 Therapeutic inhibitor of vascular smooth muscle cells | 45 | 1999 | |
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| 5,886,026 Anti-angiogenic compositions and methods of use | 182 | 1995 | |
| 5,994,341 Anti-angiogenic Compositions and methods for the treatment of arthritis | 59 | 1995 | |
| 6,506,411 Anti-angiogenic compositions and methods of use | 64 | 1999 | |
| 6,544,544 Anti-angiogenic compositions and methods of use | 119 | 2001 | |
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| 5,059,699 Water soluble derivatives of taxol | 112 | 1990 | |
| 5,352,805 Water soluble derivatives of taxol | 14 | 1991 | |
| 5,278,324 Water soluble derivatives of taxol | 49 | 1991 | |
| 5,411,984 Water soluble analogs and prodrugs of taxol | 14 | 1992 | |
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| 6,515,016 Composition and methods of paclitaxel for treating psoriasis | 25 | 1997 | |
| 6,495,579 Method for treating multiple sclerosis | 11 | 1998 | |
| 6,689,803 Compositions and methods for treating surgical adhesions | 55 | 2002 | |
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| 6,210,717 Biodegradable mixed polymeric micelles for gene delivery | 18 | 1998 | |
| 6,322,805 Biodegradable polymeric micelle-type drug composition and method for the preparation thereof | 26 | 2000 | |
| 6,616,941 Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof | 10 | 2001 | |
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| 5,350,866 10-desacetoxytaxol derivatives | 69 | 1992 | |
| 5,283,253 Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them | 90 | 1992 | |
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| 6,004,573 Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties | 106 | 1997 | |
| 6,117,949 Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties | 43 | 1998 | |
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| 5,645,856 Delivery systems for hydrophobic drugs | 77 | 1995 | |
| 5,827,541 Process for preparing solid pharmaceutical dosage forms of hydrophobic substances | 25 | 1996 | |
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| 6,017,948 Water-miscible pharmaceutical compositions | 14 | 1998 | |
| 6,136,846 Formulation for paclitaxel | 18 | 1999 | |
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| 5,274,137 Intermediates for preparation of taxols | 29 | 1992 | |
| 5,422,364 Water soluble taxol derivatives | 46 | 1993 | |
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| 5,440,056 9-deoxotaxane compounds | 44 | 1994 | |
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| 5,916,596 Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof | 110 | 1996 | |
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| 5,716,981 Anti-angiogenic compositions and methods of use | 590 | 1995 | |
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| 5,776,486 Methods and apparatus for making liposomes containing hydrophobic drugs | 33 | 1996 | |
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| 5,968,972 Method for increasing the oral bioactivity of pharmaceutical agents | 21 | 1996 | |
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| 5,939,454 Fungicidal mixtures of an oxime ether carboxylic acit amide with a dithiocarbamate | 1 | 1998 | |
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| 6,040,330 Pharmaceutical formulations of taxanes | 8 | 1999 | |
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| 5,955,509 pH dependent polymer micelles | 161 | 1997 | |
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| 5,279,949 Process for the isolation and purification of taxol and taxanes from Taxus spp | 35 | 1992 | |
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| 6,107,332 Hydrolysis-promoting hydrophobic taxane derivatives | 1 | 1999 | |
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| 6,369,037 Controlled release of doxorubicin | 1 | 2000 | |
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| 5,827,533 Liposomes containing active agents aggregated with lipid surfactants | 24 | 1997 | |
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| 4,650,913 Sulfinate-initiated addition of perfluorinated iodides to olefins | 12 | 1984 | |
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| 6,365,173 Stereocomplex polymeric carriers for drug delivery | 26 | 1999 | |
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| 5,834,019 Pharmaceutical formulation containing a hydrophobic active substance and an effervescent system | 7 | 1996 | |
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| 4,526,938 Continuous release formulations | 215 | 1983 | |
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| 5,543,158 Biodegradable injectable nanoparticles | 215 | 1993 | |
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| 5,202,448 Processes of converting taxanes into baccatin III | 29 | 1992 | |
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| 4,942,184 Water soluble, antineoplastic derivatives of taxol | 144 | 1988 | |
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| 5,362,831 Polymer-bound paclitaxel derivatives | 86 | 1993 | |
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| 6,592,899 PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water | 8 | 2001 | |
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| 5,510,103 Physical trapping type polymeric micelle drug preparation | 38 | 1995 | |
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| 5,453,521 Process for obtaining 10-deacetylbaccatin III | 12 | 1993 | |
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| 4,857,653 Process for the preparation of taxol and 10-deacetyltaxol | 172 | 1987 | |
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| 5,229,529 Method of producing .alpha.,.beta.-unsaturated ketolactones | 17 | 1992 | |
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| 5,430,021 Hydrophobic drug delivery systems | 41 | 1994 | |
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| 6,153,193 Compositions for targeting biological agents | 10 | 1995 | |
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| 4,745,160 Biodegradable amphipathic copolymers | 116 | 1985 | |
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| 5,478,860 Stable microemulsions for hydrophobic compound delivery | 49 | 1993 | |
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| 4,419,340 Controlled release of anticancer agents from biodegradable polymers | 48 | 1980 | |
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| 5,200,534 Process for the preparation of taxol and 10-deacetyltaxol | 59 | 1992 | |
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| 5,484,809 Prodrugs for oral administration containing taxol or substituted taxol covalently bound to a phospholipid | 42 | 1994 | |
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| 5,843,891 Pharmaceutical acceptable compositions containing an alcohol and a hydrophobic drug | 23 | 1995 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 3.5 Year Payment | $1600.00 | $800.00 | $400.00 | Jul 25, 2014 |
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jul 25, 2018 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jul 25, 2022 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 3.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |