Micellar drug delivery systems for hydrophobic drugs

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7875677
APP PUB NO 20090105351A1
SERIAL NO

12193648

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

This invention provides compositions comprising a hydrophobic drug, a biocompatible micelle forming polymer, and a biocompatible low molecular weight, water-soluble polymer. Also provided are devices for injection of such compositions and for the use of such compositions to form hydrophobic drug containing micelles within the body of a patient.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
THE UNIVERSITY OF BRITISH COLUMBIAVANCOUVER330

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burt, Helen M Vancouver, CA 28 392
Jackson, John K Vancouver, CA 36 565
Zastre, Jason Vancouver, CA 3 10

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
5843891 Pharmaceutical acceptable compositions containing an alcohol and a hydrophobic drug 40 1995
 
Gerhard Gergely (1)
5834019 Pharmaceutical formulation containing a hydrophobic active substance and an effervescent system 7 1996
 
KIM PH.D., SUNG WAN (2)
6004573 Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties 229 1997
6117949 Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties 86 1998
 
CEPHALON LIMITED (1)
6107332 Hydrolysis-promoting hydrophobic taxane derivatives 3 1999
 
ANGIOTECH PHARMACEUTICALS, INC. (4)
5886026 Anti-angiogenic compositions and methods of use 276 1995
5994341 Anti-angiogenic Compositions and methods for the treatment of arthritis 82 1995
6506411 Anti-angiogenic compositions and methods of use 96 1999
6544544 Anti-angiogenic compositions and methods of use 176 2001
 
APHIOS CORPORATION (1)
5776486 Methods and apparatus for making liposomes containing hydrophobic drugs 40 1996
 
IPXMEDICAL, LLC (3)
6515016 Composition and methods of paclitaxel for treating psoriasis 45 1997
6495579 Method for treating multiple sclerosis 20 1998
6689803 Compositions and methods for treating surgical adhesions 95 2002
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
5955509 pH dependent polymer micelles 217 1997
 
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (1)
4942184 Water soluble, antineoplastic derivatives of taxol 162 1988
 
The Scripps Research Institute (2)
5274137 Intermediates for preparation of taxols 35 1992
5422364 Water soluble taxol derivatives 53 1993
 
ANGIOTECH BIOCOATINGS CORP. (1)
5716981 Anti-angiogenic compositions and methods of use 817 1995
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
5543158 Biodegradable injectable nanoparticles 390 1993
 
MAYNE PHARMA (USA) INC. (1)
5202448 Processes of converting taxanes into baccatin III 38 1992
 
BAKER NORTON PHARMACEUTICALS, INC. (1)
5968972 Method for increasing the oral bioactivity of pharmaceutical agents 29 1996
 
Rhone-Poulenc S.A. (1)
5453521 Process for obtaining 10-deacetylbaccatin III 13 1993
 
Rhone-Poulenc Sante (1)
4857653 Process for the preparation of taxol and 10-deacetyltaxol 180 1987
 
VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (4)
5059699 Water soluble derivatives of taxol 118 1990
5352805 Water soluble derivatives of taxol 18 1991
5278324 Water soluble derivatives of taxol 58 1991
5411984 Water soluble analogs and prodrugs of taxol 21 1992
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
5200534 Process for the preparation of taxol and 10-deacetyltaxol 68 1992
 
Supernus Pharmaceuticals, Inc. (1)
5430021 Hydrophobic drug delivery systems 53 1994
 
BRISTOL-MYERS SQUIBB COMPANY (8)
5248796 Taxol derivatives 79 1992
5300638 Asymmetric synthesis of taxol side chain 32 1992
5272171 Phosphonooxy and carbonate derivatives of taxol 102 1992
5254580 7,8-cyclopropataxanes 121 1993
5294637 Fluoro taxols 75 1993
5380751 6,7-modified paclitaxels 38 1993
5412092 N-substituted 2-azetidinones 45 1993
5395850 6,7-epoxy paclitaxels 23 1994
 
E. I. DU PONT DE NEMOURS AND COMPANY (1)
4650913 Sulfinate-initiated addition of perfluorinated iodides to olefins 12 1984
 
ABBOTT LABORATORIES (1)
5440056 9-deoxotaxane compounds 48 1994
 
CORNELL UNIVERSITY (1)
6369037 Controlled release of doxorubicin 2 2000
 
RESEARCH DEVELOPMENT CORPORATION OF JAPAN (1)
5510103 Physical trapping type polymeric micelle drug preparation 55 1995
 
Supratek Pharma Inc. (1)
6153193 Compositions for targeting biological agents 12 1995
 
TEKMIRA PHARMACEUTICALS CORPORATION (1)
5478860 Stable microemulsions for hydrophobic compound delivery 61 1993
 
EFRAT BIOPOLYMERS LTD. (1)
6365173 Stereocomplex polymeric carriers for drug delivery 51 1999
 
UNIVERSITY OF DELAWARE (1)
4419340 Controlled release of anticancer agents from biodegradable polymers 51 1980
 
BTG INTERNATIONAL INC. (1)
6592899 PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water 27 2001
 
SYNGENTA LIMITED (1)
4745160 Biodegradable amphipathic copolymers 147 1985
 
DUKE UNIVERSITY (1)
5827533 Liposomes containing active agents aggregated with lipid surfactants 41 1997
 
VESTAR, INC. (1)
5484809 Prodrugs for oral administration containing taxol or substituted taxol covalently bound to a phospholipid 53 1994
 
SUPERGEN, INC. (2)
6017948 Water-miscible pharmaceutical compositions 21 1998
6136846 Formulation for paclitaxel 54 1999
 
SUCAMPO AG (1)
5229529 Method of producing .alpha.,.beta.-unsaturated ketolactones 28 1992
 
AVENTIS PHARMA S.A. (6)
4814470 Taxol derivatives, their preparation and pharmaceutical compositions containing them 266 1987
5393895 Process for obtaining 10-deacetylbaccatin III 9 1993
5393896 Process for obtaining 10-deacetylbaccatin III 8 1993
5717103 Process for the esterification of baccatin III and of 10-deacetylbaccatin III 5 1995
5736366 Process for obtaining 10-deacetylbaccatin III 6 1995
5977375 Esters of baccatin III and 10-deacetylbaccatin III 1 1997
 
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (1)
5279949 Process for the isolation and purification of taxol and taxanes from Taxus spp 44 1992
 
ABRAXIS BIOSCIENCE, LLC (1)
5916596 Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof 176 1996
 
PHARMACIA & UPJOHN S.P.A. (1)
5362831 Polymer-bound paclitaxel derivatives 111 1993
 
SAMYANG BIOPHARMACEUTICALS CORPORATION (3)
6210717 Biodegradable mixed polymeric micelles for gene delivery 31 1998
6322805 Biodegradable polymeric micelle-type drug composition and method for the preparation thereof 47 2000
6616941 Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof 19 2001
 
BOSTON SCIENTIFIC SCIMED, INC. (5)
5811447 Therapeutic inhibitor of vascular smooth muscle cells 222 1995
5981568 Therapeutic inhibitor of vascular smooth muscle cells 337 1997
6306421 Therapeutic inhibitor of vascular smooth muscle cells 108 1997
6231600 Stents with hybrid coating for medical devices 421 1999
6358989 Therapeutic inhibitor of vascular smooth muscle cells 55 1999
 
R.P. SCHERER CORPORATION (2)
5645856 Delivery systems for hydrophobic drugs 145 1995
5827541 Process for preparing solid pharmaceutical dosage forms of hydrophobic substances 28 1996
 
BIONUMERIK PHARMACEUTICALS, INC. (1)
6040330 Pharmaceutical formulations of taxanes 24 1999
 
BASF AKTIENGESELLSCHAFT (1)
5939454 Fungicidal mixtures of an oxime ether carboxylic acit amide with a dithiocarbamate 1 1998
 
IMPERIAL CHEMICAL INDUSTRIES PLC (1)
4526938 Continuous release formulations 309 1983
 
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (2)
5350866 10-desacetoxytaxol derivatives 73 1992
5283253 Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them 99 1992
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (1)
8858965 Micelle encapsulation of a combination of therapeutic agents 0 2013
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (2)
* 9283185 Liposomal curcumin for treatment of cancer 0 2011
* 2011/0287,085 LIPOSOMAL CURCUMIN FOR TREATMENT OF CANCER 5 2011
* Cited By Examiner

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 Jul 25, 2018
11.5 Year Payment $7400.00 $3700.00 $1850.00 Jul 25, 2022
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00