US Patent No: 7,879,028

Number of patents in Portfolio can not be more than 2000

Osmotic delivery systems and piston assemblies for use therein

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ALSO PUBLISHED AS: 20100185184
ATTORNEY / AGENT: (SPONSORED)
 

Importance

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Abstract

An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.

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First Claim

Related Publications

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Patent Owner(s)

Patent OwnerAddressTotal Patents
INTARCIA THERAPEUTICS, INC.EMERYVILLE, CA75

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alessi, Thomas R Hayward, CA 28 117
DesJardin, Michael A - 54 257
Lam, Stan Dublin, CA 25 110
Lautenbach, Scott D - 38 691
Zamora, Pauline C - 19 94

Cited Art

Patent Info (Count) # Cites Year
 
INTARCIA THERAPEUTICS, INC. (39)
5,728,396 Sustained delivery of leuprolide using an implantable system 164 1997
5,985,305 Sustained delivery of an active agent using an implantable system 82 1997
6,132,420 Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems 44 1997
5,997,527 Self adjustable exit port 50 1998
6,113,938 Beneficial agent delivery system with membrane plug and method for controlling delivery of beneficial agents 49 1998
6,287,295 Osmotic delivery system, osmotic delivery system semimpermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems 60 1998
6,524,305 Osmotic delivery system flow modulator apparatus and method 37 1998
6,375,978 Rate controlling membranes for controlled drug delivery devices 56 1998
6,270,787 Osmotic delivery system with membrane plug retention mechanism 47 1998
5,972,370 Peptide/protein suspending formulations 36 1999
6,156,331 Sustained delivery of an active agent using an implantable system 41 1999
6,261,584 Sustained delivery of an active agent using an implantable system 70 1999
6,217,906 Self adjustable exit port 18 1999
6,544,252 Osmotic delivery system having space efficient piston 32 1999
7,258,869 Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle 26 2000
6,508,808 Valve for osmotic devices 33 2000
6,395,292 Sustained delivery of an active agent using an implantable system 55 2001
6,976,981 Osmotic delivery system with membrane plug retention mechanism 7 2001
6,923,800 Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems 21 2001
6,635,268 Sustained delivery of an active agent using an implantable system 29 2002
7,163,688 Osmotic implant with membrane and membrane retention means 26 2002
6,840,931 Osmotic delivery system flow modulator apparatus and method 18 2002
7,014,636 Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel 31 2002
6,682,522 Valve for osmotic devices 9 2002
7,074,423 Osmotic delivery system with early zero order push power engine 26 2003
6,939,556 Minimally compliant, volume efficient piston for osmotic drug delivery systems 33 2003
2004/0224,903 Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device 39 2003
7,207,982 Osmotic pump with means for dissipating internal pressure 26 2004
6,997,922 Osmotic delivery system having space efficient piston 9 2004
2005/0112,188 Composition and dosage form comprising an amphiphilic molecule as a suspension vehicle 27 2004
2005/0175,701 Capillary moderator for osmotic delivery system 26 2005
2005/0266,087 Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium 35 2005
7,112,335 Minimally compliant, volume-efficient piston for osmotic drug delivery systems 7 2005
2006/0193,918 Solvent/polymer solutions as suspension vehicles 25 2006
2006/0251,618 Implantable device for continuous delivery of interferon 13 2006
2006/0263,433 Suspension formulation of interferon 14 2006
2006/0246,138 Polyoxaester suspending vehicles for use with implantable delivery systems 26 2006
2007/0281,024 Two-Piece, Internal-Channel Osmotic Delivery System Flow Modulator 26 2007
7,682,356 Osmotic delivery systems and piston assemblies for use therein 10 2007
 
BALSELLS, PETER J. (11)
4,826,144 Inside back angle canted coil spring 35 1988
4,830,344 Canted-coil spring with turn angle and seal 31 1988
4,876,781 Method of making a garter-type axially resilient coiled spring 23 1988
4,961,253 Manufacturing method for canted-coil spring with turn angle and seal 14 1988
5,134,244 Electromagnetic shielding seal for rotary/reciprocating shaft 23 1989
4,974,821 Canted-coil spring with major axis radial loading 19 1989
4,964,204 Method for making a garter-type axially-resilient coil spring 14 1989
4,915,366 Outside back angle canted coil spring 28 1989
5,108,078 Canted-coil spring loaded while in a cavity 31 1990
5,160,122 Coil spring with an elastomer having a hollow coil cross section 21 1990
5,161,806 Spring-loaded, hollow, elliptical ring seal 25 1992
 
DURECT CORPORATION (9)
5,904,935 Peptide/protein suspending formulations 30 1995
5,932,547 Non-aqueous polar aprotic peptide formulations 39 1997
6,124,261 Non-aqueous polar aprotic peptide formulations 36 1999
6,235,712 Non-aqueous polar aprotic peptide formulations 31 2000
2005/0008,661 Non-aqueous single phase vehicles and formulations utilizing such vehicles 38 2004
2005/0101,942 Device and method for accurate delivery of an active agent 7 2004
2005/0276,856 Non-aqueous single phase vehicles and formulations utilizing such vehicles 26 2005
2006/0216,242 Suspending vehicles and pharmaceutical suspensions for drug dosage forms 28 2006
2007/0027,105 Peroxide removal from drug delivery vehicle 23 2006
 
ALZA CORPORATION (1)
5,413,572 Osmotic dosage system for liquid drug delivery 49 1994
 
BALSELLS, JOAN C., CO-TRUSTEES (1)
4,893,795 Radially loaded canted coiled spring with turn angle 20 1988
 
BALSELLS, PETER J. AND BALSELLS, JOAN C., CO-TRUSTEES, UNDER DECLARATION OF TRUST DATED 10-1-85, A TRUST OF CA (1)
4,655,462 Canted coiled spring and seal 79 1985
 
BALSELLS, PETER J. AND BALSELLS, JOAN C., CO-TRUSTEES, UNDER THE DECLARATION OF TRUST DATED 10-1-85, UNDER THE STATE OF CA (1)
4,907,788 Dual concentric canted-coil spring apparatus 27 1989
 
BALSELLS, PETER J., AND JOAN C., CO-TRUSTEES UNDER DECLARATION OF TRUST DATE 10-1-85, UNDER THE LAWS OF CA (1)
4,934,666 Coiled spring electromagnetic shielding gasket 30 1989
 
BALSELLS, PETER J., CO-TRUSTEE, UNDER DECLARATION OF TRUST DATED 10-01-85 (1)
5,079,388 Gasket for sealing electromagnetic waves 19 1990
 
BALSELLS, PETER J., CO-TRUSTEE, UNDER DECLARATION OF TRUST DATED 10-1-85, UNDER THE LAWS OF THE STATE OF CA (1)
5,203,849 Canted coil spring in length filled with an elastomer 20 1990
 
BALSELLS, PETER J., CO-TRUSTEES (1)
5,117,066 Retaining and locking electromagnetic gasket 25 1991
 
BALSELLS, PETER J., CO-TRUSTEES, UNDER THE DECLARATION OF TRUST DATED 10-01-85. UNDER THE LAWS OF THE STATE OF CA (1)
5,072,070 Device for sealing electromagnetic waves 25 1989
 
ETHICON ENDO-SURGERY, INC. (1)
2005/0131,386 Method and device for minimally invasive implantation of biomaterial 4 2003
 
WATERS TECHNOLOGIES CORPORATION (1)
2008/0110,515 Defined Lead Path For High Pressure Seal 2 2005

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
INTARCIA THERAPEUTICS, INC. (9)
8,052,996 Two-piece, internal-channel osmotic delivery system flow modulator 2 2007
8,299,025 Suspension formulations of insulinotropic peptides and uses thereof 0 2008
8,211,467 Osmotic drug delivery devices containing suspension formulations comprising particles having active agents and nonaqueous single-phase vehicles 2 2010
8,206,745 Solvent/polymer solutions as suspension vehicles 3 2011
8,158,150 Two-piece, internal-channel osmotic delivery system flow modulator 2 2011
8,273,365 Two-piece, internal-channel osmotic delivery system flow modulator 1 2012
8,440,226 Solvent/polymer solutions as suspension vehicles 0 2012
8,367,095 Two-piece, internal-channel osmotic delivery system flow modulator 0 2012
8,460,694 Solvent/polymer solutions as suspension vehicles 0 2012

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Aug 1, 2014
7.5 Year Payment $3600.00 $1800.00 $900.00 Aug 1, 2018
11.5 Year Payment $7400.00 $3700.00 $1850.00 Aug 1, 2022
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00