Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
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United States of America Patent
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Feb 8, 2011
Grant Date -
Sep 21, 2006
app pub date -
Jan 31, 2006
filing date -
Dec 18, 1995
priority date (Note) -
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Abstract
Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked materials that may be used as adhesive compositions. The compositions comprise collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, prevention of adhesions following surgery or injury, and coating of surgically acceptable patches and solid implants, the latter including sutures.
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