Cripto blocking antibodies and uses thereof
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United States of America Patent
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Feb 15, 2011
Grant Date -
Nov 19, 2009
app pub date -
Mar 31, 2009
filing date -
Apr 26, 2001
priority date (Note) -
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status (Latency Note)
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Abstract
The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies which bind Cripto, modulate signaling, and modulate tumor growth are also provided. Antibodies which bind Cripto, block the interaction between Cripto and ALK4 and modulate tumor growth are provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications.
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