Production of high levels of transgenic factor IX without gene rescue, and its therapeutic uses
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United States of America Patent
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Feb 15, 2011
Grant Date -
Sep 24, 2009
app pub date -
Oct 21, 2008
filing date -
Mar 12, 2001
priority date (Note) -
Expired
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Abstract
A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human FIX protein without the benefit of the presence of a complete milk gene sequence for gene rescue, and a signal sequence is active in directing newly expressed Factor IX into the milk of the animal at levels in an unactivated form that is suitable for subsequent processing for therapeutic applications in treating Hemophilia B. The transgenic mammals are preferably pigs, cows, sheep, goats and rabbits. The applications include milk derivatives for oral delivery and oral tolerization in the treatment of Hemophilia B.
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