Protein folding
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United States of America Patent
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Feb 22, 2011
Grant Date -
Jul 16, 2009
app pub date -
Mar 9, 2007
filing date -
Mar 11, 2006
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention concerns a method for folding a Transforming Growth Factor Beta, or a functional analogue thereof, into a dimeric, biologically active form. The method involves adding solubilized, unfolded monomeric growth factor to a solution containing 2-(cyclohexylamino)-ethanesulfonic acid (CHES) or a functional analogue thereof and a low molecular weight sulfhydryl/disulfide redox system. The solution is then incubated under conditions suitable for generating dimeric biologically active Transforming Growth Factor Beta.
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