Situ heat induced antigen recovery and staining apparatus and method

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7897106
APP PUB NO 20060275889A1
SERIAL NO

11439722

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Abstract

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Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element preferably supports a single microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins. Because of the ability to pressurize and regulate pressure within the reaction compartment, and to individually heat each slide, each slide and a liquid solution or reagent thereon can be heated to temperatures that could not be obtained without the enclosed pressurized environment of the reaction compartment. A reagent dispensing strip having a plurality of reconfigurable reagent modules may also be used.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ANGROS, LEEBETHANY, OK4

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Angros, Lee Bethany, US 24 753
Byers, Thomas Lee Mustang, US 5 120

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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LEICA BIOSYSTEMS MELBOURNE PTY LTD (1)
D495425 Cover tile 33 2003
 
Other [Check patent profile for assignment information] (4)
5819842 Method and apparatus for temperature control of multiple samples 195 1995
5804141 Reagent strip slide treating apparatus 82 1996
* 6534008 In situ heat induced antigen recovery and staining apparatus and method 92 2000
* 6855292 In situ heat induced antigen recovery and staining apparatus and method 53 2003
 
COVARIS, INC. (2)
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UNIVERSITY OF MIAMI (1)
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American Registry of Pathology (1)
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VISION INSTRUMENTS LIMITED (3)
5425918 Apparatus for automatic tissue staining for immunohistochemistry 156 1993
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CTYOLOGIX CORPORATION (1)
6673620 Fluid exchange in a chamber on a microscope slide 69 2000
 
Immunodiagnostics, Inc. (1)
5225325 Immunohistochemical staining method and reagents therefor 96 1990
 
Bio Tek Instruments (1)
5355439 Method and apparatus for automated tissue assay 125 1991
 
FUJI PHOTO FILM CO., LTD. (1)
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Cell Marque Corporation (2)
6489171 Chemical dispensing system and method 55 1997
6649368 Composition and method for treating tissue samples 46 2000
 
BIOCARE MEDICAL, INC. (1)
6358473 Microscope slide heater 44 1999
 
DAKO DENMARK A/S (11)
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6183693 Random access slide stainer with independent slide heating regulation 133 1998
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VENTANA MEDICAL SYSTEMS, INC. (23)
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5650327 Method for mixing reagent and sample mounted on a slide 163 1995
5654199 Method for rinsing a tissue sample mounted on a slide 132 1995
5654200 Automated slide processing apparatus with fluid injector 171 1995
5737499 System for performing a plurality of independent tissue analysis 65 1996
5758033 Automated tissue assay using standardized chemicals and packages 53 1996
6093574 Method and apparatus for rinsing a microscope slide 128 1997
6594537 Automated tissue assay using standardized chemicals and packages 84 1998
6296809 Automated molecular pathology apparatus having independent slide heaters 190 1999
6403036 Temperature monitoring system for an automated biological reaction apparatus 71 1999
6403931 Slide heater calibrator and temperature converter apparatus and method 74 1999
6472217 Slide aqueous volume controlling apparatus 84 1999
6352861 Automated biological reaction apparatus 168 1999
6582962 Automated molecular pathology apparatus having independent slide heaters 107 2000
6855559 Removal of embedding media from biological samples and cell conditioning on automated staining instruments 85 2000
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7378055 Automated molecular pathology apparatus having fixed slide platforms 50 2003
7378058 Method and apparatus for modifying pressure within a fluid dispenser 21 2003
 
Biogenex Laboratories (6)
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Amoco Corporation (1)
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DYNEA CHEMICALS OY (1)
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MERCK & CO., LTD. (1)
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LAB VISION CORPORATION (1)
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Gene Tec Corporation (1)
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* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (11)
8486335 In situ heat induced antigen recovery and staining apparatus and method 2 2009
8377377 In situ heat induced antigen recovery and staining apparatus and method 5 2009
* 2010/0028,978 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 15 2009
* 2011/0150,725 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 3 2011
* 8329100 In situ heat induced antigen recovery and staining apparatus and method 6 2011
* 8313694 In situ heat induced antigen recovery and staining apparatus and method 6 2011
* 2011/0318,825 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 5 2011
* 2011/0312,085 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD 5 2011
9945763 Methods and systems for immunohistochemistry heat retrieval of biological samples 0 2012
9267868 In Situ heat induced antigen recovery and staining apparatus and method 1 2013
9766165 In situ heat induced antigen recovery and staining apparatus and method 0 2016
 
SAKURA FINETEK U.S.A., INC. (9)
9518899 Automated reagent dispensing system and method of operation 0 2006
8459509 Fluid dispensing apparatus 1 2006
* 2007/0272,710 Fluid dispensing apparatus 18 2006
8752732 Fluid dispensing system 1 2011
8932543 Automated staining system and reaction chamber 2 2011
8580568 Traceability for automated staining system 1 2011
9914124 Fluid dispensing apparatus 0 2013
9005980 Traceability for automated staining system 0 2013
9016526 Fluid dispensing system 0 2014
 
Angros, Lee H. (2)
8361388 In situ heat induced antigen recovery and staining apparatus and method 3 2011
8541244 In situ heat induced antigen recovery and staining apparatus and method 1 2011
 
ANGROS, LEE (2)
9354145 In situ heat induced antigen recovery and staining apparatus and method 1 2013
9719895 In situ heat induced antigen recovery and staining apparatus and method 0 2016
 
Biocare, LLC (1)
8501434 Method for processing non-liquid biological samples with dynamic application of a processing liquid 2 2012
 
BIOCARE MEDICAL, LLC (1)
9442049 Efficient processing systems and methods for biological samples 4 2013
* Cited By Examiner

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