Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives
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United States of America Patent
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Mar 1, 2011
Grant Date -
Nov 25, 2010
app pub date -
Jul 16, 2010
filing date -
Apr 5, 2001
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Expired
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Abstract
Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they do not require any chemical reaction on the probes or on the analytes since they are based on different electrostatic interactions between cationic poly(3-alkoxy-4-methylthiophene) derivatives and single-stranded or double-stranded (hybridized) oligonucleotides.
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