39-desmethoxy-39-methyl derivatives of rapamycin
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United States of America Patent
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Mar 1, 2011
Grant Date -
Jul 9, 2009
app pub date -
Nov 19, 2008
filing date -
May 19, 2006
priority date (Note) -
Expired
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Abstract
The present invention relates to novel 39-desmethoxy-39-methylrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxy-39 -methylrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
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