Method for assessing disease states by profile analysis of isolated circulating endothelial cells

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United States of America Patent

PATENT NO 7901950
APP PUB NO 20070154960A1
SERIAL NO

11701763

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Abstract

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Elevated number of Circulating Endothelial Cells (CEC) have been implicated in disease conditions associated with the formation or destruction of blood vessels such as acute coronary syndrome, thrombocytopenic purpura, sickle cell disease, sepsis, lupus, nephrotic syndromes, rejection of organ transplants, surgical trauma and cancer. This invention provides a method for assessing the levels of CEC which vary between different studies using a sensitive enrichment, imaging, and enumberation analysis. CD146 is one of the most specific endothelium-associated cell-surface antigens which can be used in image cytometry. CEC analysis provides an essential tool in prognostic/diagnostic evaluation in the clinic.

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Patent Owner(s)

Patent OwnerAddress
MENARINI SILICON BIOSYSTEMS S P AVIA GIUSEPPE DI VITTORIO 21 B/3 CASTEL MAGGIORE BOLOGNA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Connelly, Mark Carle Doylestown, US 15 181
Doyle, Gerald V Radnor, US 7 235
Rao, Galla Chandra Princeton Junction, US 31 1452
Terstappen, Leon W M M Huntingdon Valley, US 41 2122

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