US Patent No: 7,902,427

Number of patents in Portfolio can not be more than 2000

PUFA polyketide synthase systems and uses thereof

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ALSO PUBLISHED AS: 20080026434
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Abstract

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, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
DSM IP ASSETS B.V.6411 TE HEERLEN1221

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Metz, James G Longmont, CO 137 2119
Weaver, Craig A Boulder, CO 88 1321
Zirkle, Ross Longmont, CO 53 622

Cited Art Landscape

Patent Info (Count) # Cites Year
 
DSM IP ASSETS B.V. (50)
5,130,242 Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids 204 1990
5,908,622 Food product containing thraustochytrium and/or schizochytrium microflora and an additional agricultural based ingredient 68 1997
6,566,583 Schizochytrium PKS genes 65 1999
7,001,772 Product and process for transformation of Thraustochytriales microorganisms 58 2002
7,247,461 Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof 32 2002
7,214,853 Schizochytrium PKS genes 46 2002
7,211,418 PUFA polyketide synthase systems and uses thereof 54 2004
7,217,856 PUFA polyketide synthase systems and uses thereof 53 2004
7,256,022 Pufa polyketide synthase systems and uses thereof 46 2005
7,256,023 PUFA polyketide synthase systems and uses thereof 47 2005
7,259,295 PUFA polyketide synthase systems and uses thereof 46 2005
7,271,315 PUFA polyketide synthase systems and uses thereof 53 2006
2007/0256,146 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2007/0244,192 PLANT SEED OILS CONTAINING POLYUNSATURATED FATTY ACIDS 54 2007
2007/0270,494 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 51 2007
2007/0266,455 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
2008/0026,435 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0026,436 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
2008/0026,437 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
2008/0032,296 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 25 2007
2008/0026,438 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 35 2007
2008/0026,439 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 35 2007
2008/0026,440 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
2008/0032,351 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
2008/0038,790 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 35 2007
2008/0022,422 CHIMERIC PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 51 2007
2008/0148,433 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0038,791 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 35 2007
2008/0038,792 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 35 2007
2008/0044,867 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
2008/0038,793 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0038,794 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 41 2007
2008/0038,795 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0038,796 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 41 2007
2008/0038,797 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0040,822 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0044,868 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 41 2007
2008/0044,869 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 41 2007
2008/0044,871 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0044,872 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0044,873 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0050,790 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 40 2007
2008/0032,338 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
2008/0032,367 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
2008/0032,368 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 25 2007
2008/0032,369 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
2008/0038,798 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
2008/0038,799 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
2008/0044,874 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
2008/0050,791 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
 
Sagami Chemical Research Center (3)
5,246,841 Microbial process for production of eicosapentaenoic acid 62 1991
5,683,898 Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid 66 1995
5,798,259 Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid 54 1996
 
ABBOTT LABORATORIES (2)
6,677,145 Elongase genes and uses thereof 52 2001
7,208,590 Genes involved in polyketide synthase pathways and uses thereof 20 2003
 
E. I. DU PONT DE NEMOURS AND COMPANY (2)
2004/0172,682 Production of very long chain polyunsaturated fatty acids in oilseed plants 55 2004
7,125,672 Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts 62 2004
 
MARTEK BIOSCIENCES CORPORATION (2)
2008/0038,378 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 35 2007
2008/0038,379 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 44 2007
 
MONSANTO COMPANY (2)
5,639,790 Plant medium-chain thioesterases 94 1993
6,140,486 Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants 85 1998
 
BIORIGINAL FOOD & SCIENCE CORP. (1)
7,087,432 Fad4, Fad5, Fad5-2 and Fad6, novel fatty acid desaturase family members and uses thereof 47 2001
 
BIOTICA TECHNOLOGY LIMITED (1)
6,033,883 Production of polyketides in bacteria and yeast 76 1997
 
IACR-ROTHAMSTED (1)
2005/0089,865 Delta 6 desaturases from primulaceae, expressing plants and pufa-containing oils 54 2004
 
KOSAN BIOSCIENCES, INC. (1)
2004/0005,672 Heterologous production of polyketides 51 2003
 
Miami University, an Ohio corporation (1)
2004/0139,498 Fatty acid elongase 3-ketoacyl CoA synthase polypeptides 44 2004
 
ROCHE DIAGNOSTICS GMBH (1)
6,503,706 Method for identifying human and animal cells having an unlimited proliferation of tumor-formation potential 47 1996
 
SEMBIOSYS GENETICS INC. (1)
2007/0245,431 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 54 2007
 
SUPERMEDIA LLC (1)
2008/0044,870 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
5,672,491 Recombinant production of novel polyketides 162 1994
 
THE UNIVERSITY OF YORK (1)
2005/0164,192 Transgenic plants expressing enzymes involved in fatty acid biosynthesis 106 2005
 
WASHINGTON STATE UNIVERSITY (1)
2004/0010,817 Plant acyl-CoA synthetases 44 2003
 
Other [Check patent profile for assignment information] (1)
5,310,242 Portable infant seat 57 1992

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
DSM IP ASSETS B.V. (1)
8,309,796 Chimeric PUFA polyketide synthase systems and uses thereof 0 2011

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