US Patent No: 7,906,009

Number of patents in Portfolio can not be more than 2000

Small volume in vitro analyte sensor

Stats

ALSO PUBLISHED AS: 20090000961
ATTORNEY / AGENT: (SPONSORED)
 

Importance

Loading Importance Indicators... loading....

Abstract

A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable.The amount of analyte can be determined by coulometry, amperometry, voltammetry, and potentiometry. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.

Loading the Abstract Image... loading....

First Claim

Related Publications

Loading Related Publications... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
ABBOTT DIABETES CARE INC.ALAMEDA, CA429

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
FELDMAN, BENJAMIN J - 228 6759
Heller, Adam Austin, TX 507 25151
Say, James Breckenridge, CO 251 11170
Vreeke, Mark S Houston, TX 252 11787

Cited Art

Patent Info (Count) # Cites Year
 
MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (22)
4,224,125 Enzyme electrode 374 1978
4,392,933 Electrochemical measuring apparatus comprising enzyme electrode 168 1982
4,897,173 Biosensor and method for making the same 343 1987
5,120,420 Biosensor and a process for preparation thereof 479 1989
5,229,282 Preparation of biosensor having a layer containing an enzyme, electron acceptor and hydrophilic polymer on an electrode system 268 1990
5,266,179 Quantitative analysis method and its system using a disposable sensor 492 1991
5,185,256 Method for making a biosensor 218 1991
5,192,415 Biosensor utilizing enzyme and a method for producing the same 300 1992
5,320,732 Biosensor and measuring apparatus using the same 135 1993
5,658,443 Biosensor and method for producing the same 131 1994
5,512,159 Biosensor 177 1994
5,582,697 Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same 385 1995
5,565,085 Method for quantifying specific compound 146 1995
5,575,895 Biosensor and method for producing the same 291 1995
5,650,062 Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same 291 1995
5,651,869 Biosensor 195 1996
6,004,441 Biosensor 197 1997
5,906,921 Biosensor and method for quantitative measurement of a substrate using the same 168 1998
6,599,407 Biosensor 168 2000
6,436,255 Biosensor 55 2001
6,740,215 Biosensor 141 2001
6,885,196 Biosensor 132 2002
 
ABBOTT LABORATORIES (19)
4,954,129 Hydrodynamic clot flushing 152 1988
5,478,751 Self-venting immunodiagnositic devices and methods of performing assays 109 1994
5,520,787 Diagnostic flow cell device 167 1995
5,820,551 Strip electrode with screen printing 291 1995
5,743,861 Blood collection device 42 1996
6,063,039 Method and apparatus for obtaining blood for diagnostic tests 204 1996
6,032,059 Device for the detection of analyte and administration of a therapeutic substance 193 1997
6,129,823 Low volume electrochemical sensor 234 1997
6,764,581 Electrode with thin working layer 236 1997
6,027,459 Method and apparatus for obtaining blood for diagnostic tests 287 1997
6,071,249 Method and apparatus for obtaining blood for diagnostic tests 246 1997
6,071,251 Method and apparatus for obtaining blood for diagnostic tests 266 1997
6,093,156 Method and apparatus for obtaining blood for diagnostic tests 329 1997
6,283,926 Method and apparatus for obtaining blood for diagnostic tests 196 2000
6,206,841 Method and apparatus for obtaining blood for diagnostic tests 267 2000
6,506,168 Apparatus and method for obtaining blood for diagnostic tests 210 2000
6,306,104 Method and apparatus for obtaining blood for diagnostic tests 291 2000
6,863,800 Electrochemical biosensor strip for analysis of liquid samples 119 2002
6,939,450 Device having a flow channel 136 2002
 
ROCHE DIAGNOSTICS OPERATIONS, INC. (17)
5,128,015 Method and apparatus for amperometric diagnostic analysis 231 1989
5,104,813 Dilution and mixing cartridge 149 1989
5,108,564 Method and apparatus for amperometric diagnostic analysis 301 1991
5,352,351 Biosensing meter with fail/safe procedures to prevent erroneous indications 345 1993
5,413,690 Potentiometric biosensor and the method of its use 223 1993
5,589,326 Osmium-containing redox mediator 169 1993
5,437,999 Electrochemical sensor 471 1994
5,438,271 Biosensing meter which detects proper electrode engagement and distinguishes sample and check strips 254 1994
5,846,702 Reagent including an osmium-containing redox mediator 119 1996
5,857,983 Methods and apparatus for sampling body fluid 272 1997
5,879,311 Body fluid sampling device and methods of use 273 1997
5,951,492 Methods and apparatus for sampling and analyzing body fluid 329 1997
5,951,493 Methods and apparatus for expressing body fluid from an incision 200 1997
D427312 Combined blood sampling device and meter 53 1998
6,099,484 Methods and apparatus for sampling and analyzing body fluid 283 1999
6,352,514 Methods and apparatus for sampling and analyzing body fluid 194 2000
6,793,633 Blood and interstitial fluid sampling device 142 2001
 
ABBOTT DIABETES CARE INC. (15)
6,071,391 Enzyme electrode structure 297 1997
6,338,790 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 344 1999
6,299,757 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 340 1999
6,461,496 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 470 1999
6,616,819 Small volume in vitro analyte sensor and methods 323 1999
6,551,494 Small volume in vitro analyte sensor 295 2000
6,592,745 Method of using a small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 275 2000
6,618,934 Method of manufacturing small volume in vitro analyte sensor 415 2000
6,591,125 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 421 2000
6,607,658 Integrated lancing and measurement device and analyte measuring methods 283 2000
6,749,740 Small volume in vitro analyte sensor and methods 199 2001
6,942,518 Small volume in vitro analyte sensor and methods 218 2001
7,058,437 Methods of determining concentration of glucose 186 2003
7,335,294 Integrated lancing and measurement device and analyte measuring methods 147 2003
2008/0277,292 Small Volume In Vitro Analyte Sensor 89 2008
 
LIFESCAN, INC. (12)
5,526,120 Test strip with an asymmetrical end insuring correct insertion for measuring 268 1994
5,942,102 Electrochemical method 208 1997
6,284,125 Electrochemical cell 131 1998
6,179,979 Electrochemical cell 92 1999
6,174,420 Electrochemical cell 108 1999
6,444,115 Electrochemical method for measuring chemical reaction rates 136 2000
6,632,349 Hemoglobin sensor 133 2000
6,475,360 Heated electrochemical cell 134 2000
6,521,110 Electrochemical cell 146 2000
6,863,801 Electrochemical cell 98 2001
6,878,251 Heated electrochemical cell 114 2002
2003/0143,113 PHYSIOLOGICAL SAMPLE COLLECTION DEVICES AND METHODS OF USING THE SAME 189 2002
 
BOEHRINGER MANNHEIM GMBH (8)
5,206,147 Colorimetric assay by enzymatic oxidation in the presence of an aromatic nitroso or oxime compound 60 1989
5,096,836 Diagnostic test carrier 133 1990
5,310,885 Process for immobilizing a protein containing substance on a solid phase 109 1992
5,318,584 Blood lancet device for withdrawing blood for diagnostic purposes 274 1992
5,286,362 Method and sensor electrode system for the electrochemical determination of an analyte or an oxidoreductase as well as the use of suitable compounds therefor 300 1993
5,424,035 Test strip analysis system 122 1994
5,507,288 Analytical system for monitoring a substance to be analyzed in patient-blood 531 1995
5,834,224 Electrochemical sensor containing an enzyme linked to binding molecules bound to a noble metal surface 131 1995
 
MEDISENSE, INC. (8)
4,545,382 Sensor for components of a liquid mixture 460 1982
4,711,245 Sensor for components of a liquid mixture 407 1984
5,126,034 Bioelectrochemical electrodes 310 1989
5,264,106 Enhanced amperometric sensor 239 1993
5,509,410 Strip electrode including screen printing of a single layer 388 1994
5,682,884 Strip electrode with screen printing 313 1994
5,727,548 Strip electrode with screen printing 281 1995
5,628,890 Electrochemical sensor 562 1995
 
KYOTO DAIICHI KAGAKU CO., LTD. (7)
5,168,046 Method for determination of glucose concentration 103 1990
5,272,060 Method for determination of glucose concentration in whole blood 108 1992
5,354,447 Biosensor and method of quantitative analysis using the same 195 1992
5,382,346 Biosensor and method of quantitative analysis using the same 251 1993
5,496,453 Biosensor and method of quantitative analysis using the same 347 1994
5,720,862 Sensor and production method of and measurement method using the same 242 1996
5,781,455 Article of manufacture comprising computer usable medium for a portable blood sugar value measuring apparatus 137 1996
 
MEDTRONIC MINIMED, INC. (7)
5,391,250 Method of fabricating thin film sensors 455 1994
5,569,186 Closed loop infusion pump system with removable glucose sensor 509 1994
5,568,806 Transcutaneous sensor insertion set 372 1995
5,586,553 Transcutaneous sensor insertion set 448 1995
5,954,643 Insertion set for a transcutaneous sensor 247 1997
6,368,141 Insertion set for a transcutenous sensor with cable connector lock mechanism 158 1999
2004/0002,682 Insertion device for an insertion set and method of using the same 111 2002
 
MILES LABORATORIES, INC. (6)
4,216,245 Method of making printed reagent test devices 132 1978
4,247,297 Test means and method for interference resistant determination of oxidizing substances 147 1979
4,418,148 Multilayer enzyme electrode membrane 219 1981
4,390,621 Method and device for detecting glucose concentration 135 1982
4,427,770 High glucose-determining analytical element 145 1982
4,560,534 Polymer catalyst transducers 154 1983
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (6)
5,387,329 Extended use planar sensors 90 1993
5,494,562 Electrochemical sensors 308 1994
5,582,698 Sensor package 142 1995
5,601,694 Electrochemical sensors 102 1995
5,707,502 Sensors for measuring analyte concentrations and methods of making same 206 1996
5,770,028 Glucose and lactate sensors 128 1996
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (6)
4,484,987 Method and membrane applicable to implantable sensor 242 1983
4,671,288 Electrochemical cell sensor for continuous short-term use in tissues and blood 443 1985
4,650,547 Method and membrane applicable to implantable sensor 253 1985
4,703,756 Complete glucose monitoring system with an implantable, telemetered sensor module 554 1986
4,781,798 Transparent multi-oxygen sensor array and method of using same 306 1987
4,890,620 Two-dimensional diffusion glucose substrate sensing electrode 349 1988
 
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (5)
4,969,468 Electrode array for use in connection with a living body and method of manufacture 308 1989
5,497,772 Glucose monitoring system 525 1993
5,545,191 Method for optimally positioning and securing the external unit of a transcutaneous transducer of the skin of a living body 160 1994
5,660,163 Glucose sensor assembly 425 1995
5,791,344 Patient monitoring system 497 1996
 
BAYER CORPORATION (5)
5,575,403 Dispensing instrument for fluid monitoring sensors 225 1995
5,510,266 Method and apparatus of handling multiple sensors in a glucose monitoring instrument system 229 1995
5,653,863 Method for reducing bias in amperometric sensors 333 1996
5,632,410 Means of handling multiple sensors in a glucose monitoring instrument system 189 1996
5,798,031 Electrochemical biosensor 268 1997
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (5)
4,721,601 Molecule-based microelectronic devices 178 1984
4,717,673 Microelectrochemical devices 153 1985
4,936,956 Microelectrochemical devices based on inorganic redox active material and method for sensing 120 1987
5,034,192 Molecule-based microelectronic devices 162 1989
5,109,850 Automatic blood monitoring for medication delivery method and apparatus 237 1991
 
ASULAB S.A. (4)
5,378,628 Sensor for measuring the amount of a component in solution 268 1992
5,393,903 Mono, bis or tris(substituted 2,2'-bipyridine) iron, ruthenium, osmium or vanadium complexes and their methods of preparation 224 1992
5,395,504 Electrochemical measuring system with multizone sensors 285 1994
5,502,396 Measuring device with connection for a removable sensor 234 1994
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (4)
5,262,035 Enzyme electrodes 308 1989
5,264,104 Enzyme electrodes 384 1992
5,264,105 Enzyme electrodes 295 1993
5,593,852 Subcutaneous glucose electrode 493 1994
 
CHILDREN'S HOSPITAL MEDICAL CENTER (4)
4,401,122 Cutaneous methods of measuring body substances 210 1979
4,458,686 Cutaneous methods of measuring body substances 163 1983
4,680,268 Implantable gas-containing biosensor and method for measuring an analyte such as glucose 300 1985
4,721,677 Implantable gas-containing biosensor and method for measuring an analyte such as glucose 279 1987
 
ENERGY, UNITED STATES DEPARTMENT OF (4)
4,461,691 Organic conductive films for semiconductor electrodes 162 1983
5,082,550 Enzyme electrochemical sensor electrode and method of making it 222 1989
5,208,154 Reversibly immobilized biological materials in monolayer films on electrodes 144 1991
5,227,042 Catalyzed enzyme electrodes 123 1992
 
INTEG, INC. (4)
5,582,184 Interstitial fluid collection and constituent measurement 490 1994
5,746,217 Interstitial fluid collection and constituent measurement 296 1995
5,682,233 Interstitial fluid sampler 295 1996
5,820,570 Interstitial fluid collection and constituent measurement 213 1997
 
KUDD, ARTHUR R. (4)
4,627,445 Glucose medical monitoring system 505 1985
4,637,403 Glucose medical monitoring system 501 1985
4,787,398 Glucose medical monitoring system 382 1986
5,279,294 Medical diagnostic system 459 1990
 
MOLECULAR DEVICES CORPORATION (4)
4,911,794 Measuring with zero volume cell 261 1987
4,942,127 Polyredox couples in analyte determinations 118 1988
5,501,956 Polyredox couples in analyte determinations 107 1994
5,567,302 Electrochemical system for rapid detection of biochemical agents that catalyze a redox potential change 187 1995
 
PACESETTER, INC. (4)
4,543,955 System for controlling body implantable action device 242 1983
4,815,469 Implantable blood oxygen sensor and method of use 262 1988
4,944,299 High speed digital telemetry system for implantable device 436 1989
5,209,229 Apparatus and method employing plural electrode configurations for cardioversion of atrial fibrillation in an arrhythmia control system 317 1991
 
SANOFI-AVENTIS DEUTSCHLAND GMBH (4)
5,971,941 Integrated system and method for sampling blood and analysis 328 1997
6,036,924 Cassette of lancet cartridges for sampling blood 317 1997
6,210,420 Apparatus and method for efficient blood sampling with lancet 194 1999
6,306,152 Lancet device with skin movement control and ballistic preload 195 1999
 
SIEMENS AKTIENGESELLSCHAFT (4)
4,366,033 Method for determining the concentration of sugar using an electrocatalytic sugar sensor 170 1979
4,477,314 Method for determining sugar concentration 213 1983
4,759,371 Implantable, calibrateable measuring instrument for a body substance and a calibrating method 136 1987
5,552,027 Working electrode for electrochemical enzymatic sensor systems 104 1995
 
TERUMO KABUSHIKI KAISHA (4)
4,927,516 Enzyme sensor 289 1987
4,968,400 Enzyme sensor 122 1989
5,135,003 Automatic sphygmomanometer 125 1990
5,133,856 Ion sensor 141 1990
 
THERASENSE, INC. (4)
5,262,305 Interferant eliminating biosensors 331 1991
5,320,725 Electrode and method for the detection of hydrogen peroxide 302 1992
5,356,786 Interferant eliminating biosensor 407 1993
6,103,033 Process for producing an electrochemical biosensor 526 1998
 
YSI INCORPORATED (4)
4,356,074 Substrate specific galactose oxidase enzyme electrodes 162 1980
4,404,066 Method for quantitatively determining a particular substrate catalyzed by a multisubstrate enzyme 173 1982
5,217,595 Electrochemical gas sensor 137 1991
5,298,144 Chemically wired fructose dehydrogenase electrodes 118 1992
 
CB-CARMEL BIOTECHNOLOGY LTD. (3)
5,101,814 System for monitoring and controlling blood glucose 383 1989
5,190,041 System for monitoring and controlling blood glucose 299 1991
5,368,028 System for monitoring and controlling blood and tissue constituent levels 221 1993
 
DISETRONIC LICENSING AG (3)
5,322,063 Hydrophilic polyurethane membranes for electrochemical glucose sensors 365 1991
5,411,647 Techniques to improve the performance of electrochemical sensors 400 1994
5,695,623 Glucose measuring device 318 1994
 
E. HELLER & COMPANY, INC. (3)
6,143,164 Small volume in vitro analyte sensor 473 1998
6,120,676 Method of using a small volume in vitro analyte sensor 533 1999
6,576,101 Small volume in vitro analyte sensor 297 1999
 
GENETICS INTERNATIONAL, INC. (3)
4,758,323 Assay systems using more than one enzyme 240 1984
4,840,893 Electrochemical assay for nucleic acids and nucleic acid probes 292 1985
4,830,959 Electrochemical enzymic assay procedures 257 1986
 
I-STAT CORPORATION (3)
5,200,051 Wholly microfabricated biosensors and process for the manufacture and use thereof 508 1989
5,112,455 Method for analytically utilizing microfabricated sensors during wet-up 138 1990
5,837,454 Process for the manufacture of wholly microfabricated biosensors 190 1995
 
MILES INC. (3)
4,938,860 Electrode for electrochemical sensors 212 1985
5,202,261 Conductive sensors and their use in diagnostic assays 220 1991
5,250,439 Use of conductive sensors in diagnostic assays 239 1992
 
STAT MEDICAL DEVICES, INC. (3)
6,022,366 Lancet having adjustable penetration depth 208 1998
6,346,114 Adjustable length member such as a cap of a lancet device for adjusting penetration depth 87 1998
6,156,051 Lancet having adjustable penetration depth 235 1999
 
VICTORIA UNIVERSITY OF MANCHESTER, THE (3)
4,919,767 Sensor and method for analyte determination 139 1988
5,437,973 Enzyme-electrode sensor 107 1993
5,531,878 Sensor devices 336 1995
 
AJINOMOTO CO., INC. (2)
4,619,754 Chemically modified electrodes and their uses 230 1983
4,595,479 Modified electrode 190 1983
 
BAYER HEALTHCARE LLC (2)
5,630,986 Dispensing instrument for fluid monitoring sensors 258 1995
7,125,481 Electrochemical-sensor design 130 2004
 
BECTON, DICKINSON AND COMPANY (2)
5,001,054 Method for monitoring glucose 211 1990
6,192,891 Integrated system including medication delivery pen, blood monitoring device, and lancer 257 1999
 
BEND RESEARCH, INC. (2)
4,784,736 Functional, photochemically active, and chemically asymmetric membranes by interfacial polymerization of derivatized multifunctional prepolymers 153 1986
4,917,800 Functional, photochemically active, and chemically asymmetric membranes by interfacial polymerization of derivatized multifunctional prepolymers 119 1988
 
BIOMEDIX, INC. (2)
5,695,947 Amperometric cholesterol biosensor 193 1995
6,033,866 Highly sensitive amperometric bi-mediator-based glucose biosensor 209 1997
 
CAMBRIDGE LIFE SCIENCES PLC (2)
4,970,145 Immobilized enzyme electrodes 255 1988
5,846,744 Sensors based on polymer transformation 151 1996
 
CASE WESTERN RESERVE UNIVERSITY (2)
4,571,292 Apparatus for electrochemical measurements 302 1982
4,655,880 Apparatus and method for sensing species, substances and substrates using oxidase 315 1983
 
DEXCOM, INC. (2)
4,757,022 Biological fluid measuring device 483 1987
4,994,167 Biological fluid measuring device 315 1988
 
DUQUESNE UNIVERSITY OF THE HOLY GHOST (2)
5,387,327 Implantable non-enzymatic electrochemical glucose sensor 183 1992
5,469,846 Implantable non-enzymatic electrochemical glucose sensor 263 1994
 
ELAN CORPORATION, PLC (2)
5,807,375 Analyte-controlled liquid delivery device and analyte monitor 411 1995
5,800,420 Analyte-controlled liquid delivery device and analyte monitor 351 1996
 
FUJI ELECTRIC CO., LTD. (2)
4,407,959 Blood sugar analyzing apparatus 157 1981
4,483,924 System for controlling a printer in a blood sugar analyzer 115 1981
 
HITACHI, LTD. (2)
4,795,707 Electrochemical sensor having three layer membrane containing immobilized enzymes 146 1985
5,095,407 Double-sided memory board 54 1989
 
INTEGRIS BAPTIST MEDICAL CENTER, INC. (2)
4,352,960 Magnetic transcutaneous mount for external device of an associated implant 174 1980
RE32947 Magnetic transcutaneous mount for external device of an associated implant 139 1988
 
INVERNESS MEDICAL TECHNOLOGY, INC. (2)
5,708,247 Disposable glucose test strips, and methods and compositions for making same 378 1996
5,951,836 Disposable glucose test strip and method and compositions for making same 268 1998
 
MITSUBISHI PENCIL KABUSHIKI KAISHA (2)
5,380,422 Micro-electrode and method for preparing it 107 1992
5,376,251 Carbon micro-sensor electrode and method for preparing it 118 1993
 
NATIONAL RESEARCH DEVELOPMENT CORPORATION (2)
4,318,784 Enzymatic processes 117 1980
4,655,885 Surface-modified electrode and its use in a bioelectrochemical process 147 1986
 
OHMICRON TECHNOLOGY, INC. (2)
4,444,892 Analytical device having semiconductive organic polymeric element associated with analyte-binding substance 177 1982
5,547,555 Electrochemical sensor cartridge 56 1993
 
ROCHE DIAGNOSTICS CORPORATION (2)
5,288,636 Enzyme electrode system 367 1990
5,508,171 Assay method with enzyme electrode system 347 1994
 
ROCHE DIAGNOSTICS GMBH (2)
6,592,815 Analytical test element with a narrowed capillary channel 51 2000
6,409,740 Blood lancet system for withdrawing blood for diagnostic purposes 192 2000
 
ROCHE OPERATIONS LTD. (2)
5,366,609 Biosensing meter with pluggable memory key 341 1993
5,997,817 Electrochemical biosensor test strip 352 1997
 
SANKYO COMPANY, LIMITED (2)
4,871,440 Biosensor 264 1988
4,950,378 Biosensor 156 1988
 
SHERWOOD SERVICES AG (2)
4,653,513 Blood sampler 299 1985
4,895,147 Lancet injector 262 1988
 
TOSHIBA AMERICA RESEARCH, INC. (2)
2002/0191,558 Distributed soft handoff among IP-based base stations 2001
2002/0191,558 Distributed soft handoff among IP-based base stations 2001
 
UNIVERSITY OF NEW MEXICO (2)
4,813,424 Long-life membrane electrode for non-ionic species 178 1987
4,986,271 Vivo refillable glucose sensor 234 1989
 
ABBOTT POINT OF CARE INC. (1)
5,514,253 Method of measuring gas concentrations and microfabricated sensing device for practicing same 134 1994
 
AFFYMETRIX, INC. (1)
6,132,580 Miniature reaction chamber and devices incorporating same 114 1995
 
AGILENT TECHNOLOGIES, INC. (1)
5,997,708 Multilayer integrated assembly having specialized intermediary substrate 90 1997
 
ALLIED CORPORATION (1)
4,524,114 Bifunctional air electrode 147 1983
 
ANIMAS TECHNOLOGIES LLC (1)
5,989,409 Method for glucose sensing 173 1995
 
ARIZONA BOARD OF REGENTS (1)
4,935,345 Implantable microelectronic biochemical sensor incorporating thin film thermopile 229 1987
 
ARMINES (1)
4,206,755 Method and apparatus for the control and regulation of glycemia 188 1978
 
ASAHI GLASS COMPANY, LIMITED (1)
5,849,055 Process for producing inorganic microspheres 64 1997
 
AT&T BELL LABORATORIES (1)
5,280,551 Backplane optical spine 48 1992
 
AVL MEDICAL IMSTRUMENTS AG (1)
5,130,009 Sensor device 111 1990
 
BASF AKTIENGESELLSCHAFT (1)
4,526,661 Electrochemical hydrogenation of nicotinamide adenine dinucleotide 142 1983
 
BAXTER INTERNATIONAL INC. (1)
4,974,929 Fiber optical probe connector for physiologic measurement devices 253 1990
 
BIOFIELD CORP. (1)
5,560,357 D.C. epidermal biopotential sensing electrode assembly and apparatus for use therewith 121 1995
 
BIOSPECIFIC TECHNOLOGIES, INC. (1)
4,534,356 Solid state transcutaneous blood gas sensors 217 1982
 
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (1)
5,611,900 Microbiosensor used in-situ 182 1995
 
BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY (1)
5,223,321 Tape-automated bonding of integrated circuits 42 1991
 
CALIFORNIA AND HAWAIIAN SUGAR COMPANY (1)
4,552,840 Enzyme electrode and method for dextran analysis 166 1982
 
CARDIAC PACEMAKERS, INC. (1)
4,679,562 Glucose sensor 196 1986
 
CHEVRON RESEARCH COMPANY (1)
4,627,908 Process for stabilizing lube base stocks derived from bright stock 130 1985
 
CHIRON CORPORATION (1)
5,094,951 Production of glucose oxidase in recombinant systems 131 1989
 
CIBA CORNING DIAGNOSTICS CORP. (1)
5,198,367 Homogeneous amperometric immunoassay 144 1989
 
CLINICAL DIAGNOSTIC SYSTEMS INC. (1)
4,271,119 Capillary transport device having connected transport zones 123 1980
 
CRANFIELD BIOTECHNOLOGY LTD. (1)
5,525,511 Electrochemical biosensor stability 194 1993
 
DANFOSS FLUID POWER A/S (1)
5,595,479 Hydraulic machine having teeth formed by rollers 39 1995
 
DIA-MED, INC. (1)
4,365,637 Perspiration indicating alarm for diabetics 147 1980
 
E. HELLER & COMPANY (1)
6,134,461 Electrochemical analyte 538 1998
 
E. I. DU PONT DE NEMOURS AND COMPANY (1)
5,650,002 TiO.sub.2 light scattering efficiency when incorporated in coatings 56 1995
 
EDEN MEDIZINISCHE ELEKTRONIK GMBH (1)
5,058,592 Adjustable mountable doppler ultrasound transducer device 120 1990
 
EL PASO PRODUCTS COMPANY (1)
4,450,842 Solid state reference electrode 145 1981
 
ELAN PHARMA INTERNATIONAL LIMITED (1)
5,820,622 Analyte-controlled liquid delivery device and analyte monitor 257 1996
 
ELI LILLY AND COMPANY (1)
5,786,584 Vial and cartridge reading device providing audio feedback for a blood glucose monitoring system 138 1996
 
ENDODERMIC MEDICAL TECHNOLOGIES COMPANY (1)
5,617,851 Ultrasonic transdermal system for withdrawing fluid from an organism and determining the concentration of a substance in the fluid 229 1995
 
ESA BIOSCIENCES, INC. (1)
5,873,990 Handheld electromonitor device 114 1996
 
EVREKA, INC. (1)
4,436,094 Monitor for continuous in vivo measurement of glucose concentration 285 1982
 
FACET TECHNOLOGY, INC. (1)
6,283,982 Lancing device and method of sample collection 189 1999
 
FIRST NATIONAL BANK OF BOSTON, THE (1)
4,759,828 Glucose electrode and method of determining glucose 318 1987
 
FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (1)
5,670,031 Electrochemical sensor 199 1995
 
FRESENIUS AG (1)
5,842,983 Biosensor 111 1996
 
GENERAL ELECTRIC COMPANY (1)
6,630,415 Durable hydrophilic coating for textiles 37 2001
 
GESELLSCHAFT FUER BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) (1)
4,764,485 Method for producing via holes in polymer dielectrics 114 1987
 
HABLEY MEDICAL TECHNOLOGY CORPORATION (1)
5,217,480 Capillary blood drawing device 182 1992
 
HONEYWELL INC. (1)
4,522,690 Electrochemical sensing of carbon monoxide 153 1983
 
HORIBA, LTD. (1)
4,923,586 Enzyme electrode unit 136 1989
 
HOSPIRA, INC. (1)
5,326,449 Composite membrane 145 1993
 
HYPOGUARD LIMITED (1)
4,832,797 Enzyme electrode and membrane 151 1986
 
IMPERIAL CHEMICAL INDUSTRIES PLC (1)
4,935,105 Methods of operating enzyme electrode sensors 181 1989
 
INSTITUT FUR CHEMO-UND BIOSENSORIK MUNSTER E.V. (1)
5,837,199 Measurement apparatus for analyzing fluids 46 1996
 
INSTITUTE FUR DIABETESTECHNOLOGIE GEMEINNUTZIGE FORSCHUNGS- UND ENTWICKLUNGSGESELLSCHAFT MBH (1)
4,919,141 Implantable electrochemical sensor 283 1988
 
INTERNATIONAL TECHNIDYNE CORPORATION (1)
5,518,006 Blood sampling device 216 1994
 
INVERNESS MEDICAL SWITZERLAND GMBH (1)
5,141,868 Device for use in chemical test procedures 443 1989
 
ISTITUTO SIEROTERAPICO E VACCINOGENO TOSCANO "SCLAVO" S.P.A. (1)
4,339,317 Device for performing measurements on fluids, directly in the sample container 49 1980
 
JOSLIN DIABETES CENTER, INC. (1)
4,340,458 Glucose sensor 163 1980
 
KIDDE, INC. (1)
4,726,378 Adjustable magnetic supercutaneous device and transcutaneous coupling apparatus 143 1986
 
KUMETRIX, INC. (1)
5,801,057 Microsampling device and method of construction 266 1996
 
LABORATOIRES SERONO SA (1)
4,945,045 Electrochemical methods of assay 272 1988
 
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (1)
5,120,421 Electrochemical sensor/detector system and method 252 1990
 
LAWRENCE MEDICAL SYSTEMS, INC. (1)
4,796,634 Methods and apparatus for monitoring cardiac output 143 1985
 
LEGACY GOOD SAMARITAN HOSPITAL AND MEDICAL CENTER (1)
5,711,861 Device for monitoring changes in analyte concentration 374 1995
 
LOCKHEED MARTIN CORPORATION (1)
5,293,546 Oxide coated metal grid electrode structure in display devices 158 1991
 
MALLINCKRODT SENSOR SYSTEMS, INC., (1)
5,078,854 Polarographic chemical sensor with external reference electrode 111 1990
 
MEDICAL SYSTEMS DEVELOPMENT, LLC (1)
5,025,798 Methods and apparatus for directly sensing and measuring blood related parameters 43 1990
 
MEDTRONIC, INC. (1)
5,741,211 System and method for continuous monitoring of diabetes-related blood constituents 242 1995
 
MICROBIONICS, INC. (1)
4,874,500 Microelectrochemical sensor and sensor array 279 1987
 
MIGRATA U.K. LIMITED (1)
4,654,197 Cuvette for sampling and analysis 240 1984
 
MINIMED INC., A DELAWARE CORPORATION, D/B/A MINIMED TECHNOLOGIES (1)
5,390,671 Transcutaneous sensor insertion set 475 1994
 
MITSUBISHI DENKI KABUSHIKI KAISHA (1)
4,764,416 Electric element circuit using oxidation-reduction substances 142 1987
 
MITSUBISHI PETROCHEMICAL CO., LTD. (1)
5,096,560 Electrode for electrochemical detectors 101 1990
 
MITSUI ENGINEERING & SHIPBUILDING CO., LTD. (1)
5,059,290 Electroanalytical method 44 1989
 
MOBIL OIL CORPORATION (1)
5,364,797 Sensor device containing mesoporous crystalline material 188 1993
 
MOCHIDA PHARMACEUTICAL CO., LTD. (1)
5,723,345 Method and device for specific binding assay 88 1995
 
N.V. NEDERLANDSCHE APPARATENFABRIEK NEDAP (1)
5,372,133 Implantable biomedical sensor device, suitable in particular for measuring the concentration of glucose 340 1993
 
NEC CORPORATION (1)
5,082,786 Glucose sensor with gel-immobilized glucose oxidase and gluconolactonase 147 1988
 
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (1)
5,422,246 Electrode having a polymer coating with a redox enzyme bound thereto, the polymer coating being formed on the walls of pores extending through a porous membrane 127 1993
 
NEW MEXICO STATE UNIVERSITY TECHNOLOGY TRANSFER CORPORATION (1)
5,192,416 Method and apparatus for batch injection analysis 136 1991
 
NEW OJI PAPER CO., LTD. (1)
5,037,527 Reference electrode and a measuring apparatus using the same 105 1988
 
NISSHO CORPORATION (1)
5,666,966 Suction-type blood sampler 134 1995
 
NOVA BIOMEDICAL CORPORATION (1)
5,352,348 Method of using enzyme electrode 185 1992
 
NOVO NORDISK A/S (1)
5,680,858 Method and apparatus for in vivo determination of the concentration in a body fluid of metabolically significant substances 232 1995
 
NOVOZYMES A/S (1)
5,741,688 Alkaline glucose oxidase obtained from cladosporium oxysporum 100 1995
 
NYMAN PILE DRIVING, INC. (1)
4,895,479 Lift for watercraft 54 1987
 
OMRON CORPORATION (1)
5,711,862 Portable biochemical measurement device using an enzyme sensor 131 1996
 
OMRON TATEISI ELECTRONICS CO. (1)
4,894,137 Enzyme electrode 168 1987
 
ORASURE TECHNOLOGIES, INC. (1)
5,126,247 Method, system and devices for the assay and detection of biochemical molecules 141 1988
 
OTIS ELEVATOR COMPANY (1)
5,276,294 Elevator button improved to function as a lock 40 1991
 
OTTOSENSORS CORPORATION (1)
4,682,602 Probe for medical application 169 1985
 
PALCO LABS, INC. (1)
RE32922 Blood sampling instrument 249 1987
 
PANASONIC CORPORATION (1)
5,264,103 Biosensor and a method for measuring a concentration of a substrate in a sample 397 1992
 
PHARMACONTROL CORPORATION (1)
4,750,496 Method and apparatus for measuring blood glucose concentration 211 1987
 
POLYTECHNIC UNIVERSITY (1)
5,089,112 Electrochemical biosensor based on immobilized enzymes and redox polymers 332 1990
 
PRINTPACK ILLINOIS, INC. (1)
5,089,320 Resealable packaging material 85 1990
 
R.E. STIFTUNG (1)
4,684,537 Process for the sensitization of an oxidation/reduction photocatalyst, and photocatalyst thus obtained 161 1985
 
RADELKIS ELEKTROKEMIAI MUSZERGYARTO SZOVETKEZET (1)
4,375,399 Molecule selective sensor for industrial use and procedure for its preparation 135 1980
 
RIJKSUNIVERSITEIT TE GRONINGEN (1)
5,174,291 Process for using a measuring cell assembly for glucose determination 194 1990
 
SEGARS CALIFORNIA PARTNERS, LP (1)
5,804,048 Electrode assembly for assaying glucose 178 1996
 
SENTRY MEDICAL PRODUCTS, INC., A CORP. OF MI (1)
4,848,351 Medical electrode assembly 134 1988
 
SHARP KABUSHIKI KAISHA (1)
5,140,393 Sensor device 136 1990
 
SHIMADZU CORPORATION (1)
4,820,399 Enzyme electrodes 294 1985
 
SIEMENS CORPORATION;INTELLECTUAL PROPERTY DEPARTMENT (1)
4,573,994 Refillable medication infusion apparatus 307 1981
 
SIEMENS INDUSTRY, INC. (1)
5,958,779 Coulometric analysis 40 1996
 
SMALL BUSINESS ADMINISTRATION (1)
4,210,156 Finger stick blood collection apparatus 54 1978
 
SOLARCARE TECHNOLOGIES CORPORATION (1)
5,278,079 Sealing device and method for inhibition of flow in capillary measuring devices 124 1992
 
SORENSEN BIOSCIENCE, INC. (1)
4,917,274 Miniscule droplet dispenser tip 75 1984
 
SPECTRUM SYSTEMS, INC. (1)
5,508,200 Method and apparatus for conducting multiple chemical assays 195 1992
 
SRI INTERNATIONAL (1)
5,161,532 Integral interstitial fluid sensor 184 1990
 
STEINEL GMBH & CO. KG (1)
5,767,480 Hole generation and lead forming for integrated circuit lead frames using laser machining 48 1995
 
SULZER BROTHERS LIMITED (1)
4,234,553 Process and apparatus for the preparation of ammonia and heavy water 48 1977
 
SUN MICROSYSTEMS, INC. (1)
5,320,098 Optical transdermal link 122 1992
 
TECHNICON INSTRUMENTS CORPORATION (1)
4,225,410 Integrated array of electrochemical sensors 302 1978
 
TERUMO CARDIOVASCULAR SYSTEMS CORPORATION (1)
4,934,369 Intravascular blood parameter measurement system 184 1989
 
THE CLEVELAND CLINIC FOUNDATION (1)
4,897,162 Pulse voltammetry 202 1988
 
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (1)
5,580,527 Polymeric luminophores for sensing of oxygen 126 1994
 
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (1)
5,596,150 Capacitance probe for fluid flow and volume measurements 135 1995
 
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (1)
5,568,186 Focal plane filtered multispectral multidetector imager 41 1994
 
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (1)
6,129,843 Device for the removal and concentration of neutral mercury species from and water 39 1998
 
THE UNIVERSITY OF MELBOURNE (1)
5,095,904 Multi-peak speech procession 187 1990
 
THOMSON-CSF (1)
4,420,564 Blood sugar analyzer having fixed enzyme membrane sensor 254 1981
 
THORN EMI PLC (1)
5,206,145 Method of measuring the concentration of a substance in a sample solution 108 1991
 
THORNE, SMITH, ASTILL TECHNOLOGIES, INC. (1)
5,108,889 Assay for determining analyte using mercury release followed by detection via interaction with aluminum 203 1988
 
TOKYO SHIBAURA DENKI KABUSHIKI KAISHA (1)
4,388,166 Electrochemical measuring apparatus provided with an enzyme electrode 180 1982
 
TOYO BOSEKI KABUSHIKI KAISHA (1)
4,240,889 Enzyme electrode provided with immobilized enzyme membrane 271 1979
 
UNIVERSITY OF KANSAS (1)
5,165,407 Implantable glucose sensor 446 1991
 
UNIVERSITY OF PITTSBURGH (1)
4,805,624 Low-potential electrochemical redox sensors 215 1987
 
UNIVERSITY PATENTS, INC. (1)
4,440,175 Membrane electrode for non-ionic species 162 1981
 
UOP LLC (1)
4,581,336 Surface-modified electrodes 163 1983
 
USF FILTRATION AND SEPARATIONS GROUP INC. (1)
4,629,563 Asymmetric membranes 208 1981
 
VALTION TEKNILLINEN TUTKIMUSKESKUS (1)
5,556,524 Electron-conducting molecular preparations 133 1995
 
VIA MEDICAL CORPORATION (1)
5,271,815 Method for measuring glucose 155 1991
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (1)
4,240,438 Method for monitoring blood glucose levels and elements 207 1978
 
YACYNYCH, ALEXANDER M. (1)
5,286,364 Surface-modified electochemical biosensor 272 1991
 
YASSINZADEH, ZIA (1)
5,700,695 Sample collection and manipulation method 278 1994
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (22)
4,384,586 Method and apparatus for pH recording 140 1980
4,431,004 Implantable glucose sensor 419 1981
4,469,110 Device for causing a pinprick to obtain and to test a drop of blood 329 1982
4,462,405 Blood letting apparatus 184 1982
4,538,616 Blood sugar level sensing and monitoring transducer 265 1983
4,633,878 Device for the automatic insulin or glucose infusion in diabetic subjects, based on the continuous monitoring of the patient's glucose, obtained without blood withdrawal 225 1984
4,595,011 Transdermal dosimeter and method of use 202 1984
4,685,463 Device for continuous in vivo measurement of blood glucose concentrations 257 1986
4,726,716 Fastener for catheter 145 1986
5,070,535 Transcutaneous power and signal transmission system and methods for increased signal transmission efficiency 162 1987
4,822,337 Insulin delivery method and apparatus 153 1987
4,871,351 Implantable medication infusion system 420 1987
4,776,944 Chemical selective sensors utilizing admittance modulated membranes 216 1987
4,909,908 Electrochemical cncentration detector method 166 1988
4,953,552 Blood glucose monitoring system 595 1989
5,205,920 Enzyme sensor and method of manufacturing the same 227 1990
5,201,324 Disposable skin perforator and blood testing device 214 1991
5,337,747 Implantable device for estimating glucose levels 289 1993
5,830,341 Electrodes and metallo isoindole ringed compounds 115 1996
6,190,398 Lancet device 70 1999
2003/0155,237 Electrodes, methods, apparatuses comprising micro-electrode arrays 74 2002
2004/0031,682 Method for determining the concentration of an analyte in a liquid sample using small volume samples and fast test times 133 2003

Patent Citation Ranking

Forward Cites

  • No Forward Cites to Display

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Sep 15, 2014
7.5 Year Payment $3600.00 $1800.00 $900.00 Sep 15, 2018
11.5 Year Payment $7400.00 $3700.00 $1850.00 Sep 15, 2022
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00