Nucleic acid-enzyme complex
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United States of America Patent
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Mar 22, 2011
Grant Date -
Mar 26, 2009
app pub date -
Apr 18, 2005
filing date -
May 11, 2004
priority date (Note) -
Expired
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Abstract
The present invention provides a method for controlling cleavage of a target RNA by deoxyribozyme.The present inventors designed a nucleic acid-enzyme complex using GGA 12-mer (Reference 3), which was found in the laboratory of the inventors to have greatly changeable structure in the presence or absence of monovalent metal ion as well as previously known nucleic acid-enzyme. The present invention is a deoxyribozyme complex comprising deoxyribozyme having a nucleotide sequence of target RNA, a substrate binding domain and a catalytic domain of RNA cleavage reaction, and a sequence (5′GGAGGAGGAGGA3′(SEQ ID NO: 21)), wherein the sequence is inserted to the catalytic domain of RNA cleavage reaction.
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