Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent
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United States of America Patent
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Mar 29, 2011
Grant Date -
Feb 3, 2005
app pub date -
Jul 31, 2003
filing date -
Jul 31, 2003
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region comprising a polymer. The polymeric release region is treated with a radiation dose that is effective to substantially increase the cumulative release of the therapeutic agent subsequent to administration to a patient. The polymeric release region can be, for example, (a) a carrier region that comprises the therapeutic agent or (b) a barrier region that is disposed over a therapeutic-agent-containing region that comprises the therapeutic agent. The present invention is further directed to methods of forming such medical devices, methods of releasing a therapeutic agent within a patient using such medical devices, and methods of modulating the release of a therapeutic agent from such medical devices.
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