Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
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United States of America Patent
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Apr 12, 2011
Grant Date -
Apr 20, 2006
app pub date -
Nov 30, 2005
filing date -
Jul 13, 1998
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Abstract
In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and systemic treatments or for immunization with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
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