Methods for decreasing osteoclast formation or bone resorption using an antibody to osteoprotegerin binding protein
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United States of America Patent
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Apr 12, 2011
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app pub date -
Jan 19, 2006
filing date -
Apr 16, 1997
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Abstract
A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host cells for production, methods of preparing osteoprotegerin binding protein, and binding assays are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget's disease are also provided.
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