Conformation specific antibodies
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United States of America Patent
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Apr 19, 2011
Grant Date -
Mar 20, 2008
app pub date -
Feb 22, 2005
filing date -
Feb 19, 2004
priority date (Note) -
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Abstract
The disclosure provides, inter alia, binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g., activated LFA-1 (“aLFA-1”), e.g., relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder.
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