US Patent No: 7,928,118

Number of patents in Portfolio can not be more than 2000

Reduction of imiquimod impurities in pharmaceutical creams

ALSO PUBLISHED AS: 20100130532

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Importance

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Abstract

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Pharmaceutical formulations and methods including an immune response modifier (IRM) compound and an oleic acid component are provided where stability is improved by using oleic acid have low polar impurities such as peroxides.

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First Claim

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all claims..

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MEDICIS PHARMACEUTICAL CORPORATIONSCOTTSDALE, AZ118

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nelson, Robert J Orlando, FL 132 1844
Statham, Alexis S Woodbury, MN 66 362

Cited Art Landscape

Patent Info (Count) # Cites Year
 
3M INNOVATIVE PROPERTIES COMPANY (25)
6,039,969 Immune response modifier compounds for treatment of TH2 mediated and related diseases 198 1997
6,110,929 Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof 183 1999
6,245,776 Formulations and methods for treatment of mucosal associated conditions with an immune response modifier 191 2000
6,200,592 Immine response modifier compounds for treatment of TH2 mediated and related diseases 89 2000
6,331,539 Sulfonamide and sulfamide substituted imidazoquinolines 176 2000
6,451,810 Amide substituted imidazoquinolines 152 2000
6,656,938 Urea substituted imidazoquinoline ethers 132 2001
6,660,747 Amido ether substituted imidazoquinolines 127 2001
6,664,260 Heterocyclic ether substituted imidazoquinolines 121 2001
6,664,264 Thioether substituted imidazoquinolines 132 2001
6,670,372 Aryl ether substituted imidazoquinolines 126 2001
6,683,088 Sulfonamido ether substituted imidazoquinolines 126 2001
6,756,382 Amide substituted imidazoquinolines 99 2001
6,525,064 Sulfonamido substituted imidazopyridines 148 2002
6,545,016 Amide substituted imidazopyridines 144 2002
6,545,017 Urea substituted imidazopyridines 145 2002
6,664,265 Amido ether substituted imidazoquinolines 132 2002
6,667,312 Thioether substituted imidazoquinolines 131 2002
2003/0199,538 Pharmaceutical formulation comprising an immune response modifier 99 2002
6,677,349 Sulfonamide and sulfamide substituted imidazoquinolines 128 2003
6,797,718 Ether substituted imidazopyridines 97 2003
2004/0091,491 Immunostimulatory compositions and methods of stimulating an immune response 84 2003
6,818,650 1H-imidazo dimers 96 2003
2004/0132,766 1H-imidazo dimers 54 2003
2004/0147,543 Aryl substituted imidazoquinolines 85 2003
 
COLEY PHARMACEUTICAL GROUP, INC. (10)
5,268,376 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines 229 1991
5,266,575 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines 226 1991
5,352,784 Fused cycloalkylimidazopyridines 221 1993
5,446,153 Intermediates for imidazo[4,5-c]pyridin-4-amines 193 1994
5,482,936 Imidazo[4,5-C]quinoline amines 206 1995
6,376,669 Dye labeled imidazoquinoline compounds 161 2000
6,660,735 Urea substituted imidazoquinoline ethers 131 2002
6,677,347 Sulfonamido ether substituted imidazoquinolines 126 2002
6,677,348 Aryl ether substituted imidazoquinolines 126 2002
2004/0176,367 1-Amino 1H-imidazoquinolines 80 2004
 
MEDICIS PHARMACEUTICAL CORPORATION (7)
5,389,640 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines 238 1992
5,736,553 Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo?4,5-C!quinolin-4-amine 59 1995
5,939,090 Gel formulations for topical drug delivery 182 1996
6,541,485 Urea substituted imidazoquinolines 139 2000
6,573,273 Urea substituted imidazoquinolines 134 2001
2004/0192,585 Treatment for basal cell carcinoma 79 2004
2007/0167,479 Immune response modifier formulations and methods 47 2005
 
Riker Laboratories, Inc. (4)
4,751,087 Transdermal nitroglycerin delivery system 85 1985
4,698,348 1H-imidazo[4,5-c]quinolines and their use as bronchodilating agents 256 1985
4,929,624 Olefinic 1H-imidazo(4,5-c)quinolin-4-amines 257 1989
5,756,747 1H-imidazo?4,5-c!quinolin-4-amines 192 1995
 
Noven Pharmaceuticals, Inc. (3)
5,300,291 Method and device for the release of drugs to the skin 83 1991
6,562,363 Bioadhesive compositions and methods for topical administration of active agents 133 1998
6,638,528 Compositions and methods to effect the release profile in the transdermal administration of active agents 88 2002
 
ALZA CORPORATION (2)
4,746,515 Skin permeation enhancer compositions using glycerol monolaurate 104 1987
6,210,712 Dosage form having first and second coats 44 1998
 
CORIUM INTERNATIONAL, INC. (2)
6,803,420 Two-phase, water-absorbent bioadhesive composition 72 2002
2003/0170,308 Hydrogel compositions 71 2002
 
GALENIX INNOVATIONS (2)
2003/0096,012 Film-forming powder, compositions containing it, methods for their preparation and their uses 44 2002
2003/0124,191 Use of an immediate-release powder in pharmaceutical and nutraceutical compositions 47 2002
 
GRACEWAY PHARMACEUTICALS, LLC (2)
4,689,338 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use 305 1985
5,238,944 Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine 222 1992
 
Minnesota Mining and Manufacturing Company (2)
4,411,893 Topical medicament preparations 64 1982
5,346,905 1-substituted 1H-imidazo-[4,5-C]quinolin-4-amines 225 1992
 
Westwood Pharmaceuticals, Inc. (2)
4,191,767 Method for treating fungal infection in mammals with imidazo [1,2-a]quinoxalines 41 1977
4,197,403 4-Aminosubstituted imidazo(1,2-A)quinoxalines 37 1977
 
A.V. TOPCHIEV INSTITUTE OF PETROCHEMICAL SYNTHESES, RUSSIAN ACADEMY OF SCIENCES (1)
2004/0242,770 Covalent and non-covalent crosslinking of hydrophilic polymers and adhesive compositions prepared therewith 50 2004
 
ABB TECHNOLOGY AG (1)
2004/0089,855 High oleic acid oil compositions and methods of making and electrical insulation fluids and devices comprising the same 30 2003
 
AGIS INDUSTRIES (1983) LTD. (1)
2006/0034,779 Foamable compositions containing vitamin D3 analogues, processes for preparing same and methods of treatment utilizng same 34 2005
 
ASTRA AKTIEBOLAG (1)
6,103,697 Peptides with immunomodulatory effects 34 1997
 
COGNIS CORPORATION (1)
6,498,261 Process for improving color and color stability of oleic acid 30 1995
 
DERMATRENDS, INC. (1)
2003/0072,814 Topical pharmaceutical composition for the treatment of warts 80 2002
 
FUJIMORI KOGYO CO., LTD. (1)
4,686,125 Film laminate for sterile flexible containers 102 1984
 
HENKEL CORPORATION (1)
2002/0128,345 Hot melt adhesives for dermal application 37 2000
 
Hisamitsu Pharmaceuticals (1)
7,504,114 Preparations for percutaneous absorption 30 2000
 
INTERCONNECTRON GMBH (1)
6,425,776 Circular plug and socket connector for producing electrical line connections 33 2000
 
KYTHERA BIOPHARMACEUTICALS, INC. (1)
2005/0201,959 Methods and compositions for altering skin coloration 31 2004
 
LTS LOHMANN THERAPIE-SYSTEME AG (1)
7,056,528 Transdermal therapeutic system containing tulobuterol hydrochloride for administering the bronchodilator tulobuterol via the skin 32 2000
 
LUITPOLD PHARMACEUTICALS, INC. (1)
5,919,815 Taxane compounds and compositions 107 1996
 
MEPHA AG (1)
2006/0039,931 Stable cream preparations of phenyl-pyridone compounds for topical application 33 2003
 
MITSUI CHEMICALS, INC. (1)
5,532,030 Polyolefin multilayer laminate, vessel and packaging material 67 1995
 
Nippon Oil and Fats Co., Ltd. (1)
4,601,856 Method of purifying oleic acid 35 1985
 
NUVO RESEARCH INC. (1)
2005/0276,842 Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same 52 2005
 
PERICOR SCIENCE, INC. (1)
6,267,957 Attaching agents to tissue with transglutaminase and a transglutaminase substrate 82 1999
 
PERRIGO ISRAEL PHARMACEUTICALS LTD. (1)
2006/0024,243 Foamable compositions containing nitro-imidazoles, processes for preparing same and methods of treatment utilizing same 31 2005
 
PHARMACIA & UPJOHN COMPANY (1)
2003/0211,163 Combination antiviral therapy 32 2003
 
Purcell Jojoba International, LLC (1)
6,559,182 Method for treatment of enveloped viruses using jojoba oil esters 32 2001
 
RANBAXY LABORATORIES LIMITED (1)
2005/0037,030 Stable topical formulation of clarithromycin 30 2004
 
SHISEIDO COMPANY, LTD. (1)
5,472,982 Emulsified external treatment composition containing diclofenac sodium 31 1993
 
SOLVAY PHARMACEUTICALS GMBH (1)
4,722,941 Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof 95 1978
 
TAKEDA CHEMICAL INDUSTRIES, LTD. (1)
4,695,465 Soft patch 113 1985
 
TAKEDA PHARMACEUTICAL COMPANY LIMITED (1)
6,194,425 Imidazonaphthyridines 181 1998
 
The Procter & Gamble Company (1)
5,008,110 Storage-stable transdermal patch 97 1988
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
2005/0175,630 Immunogenic compositions and methods of use thereof 42 2004
 
THERATECH, INC. (1)
4,863,970 Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols 172 1988
 
VIRUN, INC. (1)
2005/0281,772 Compositions for mucosal delivery of agents 56 2005
 
Warner-Lambert Company (1)
4,908,389 Penetration enhancement system 50 1986
 
Other [Check patent profile for assignment information] (2)
2003/0026,794 Selective enzyme treatment of skin conditions 38 2001
2003/0059,471 Oral delivery formulation 76 2001

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
MEDICIS PHARMACEUTICAL CORPORATION (2)
8,598,196 Methods of treating dermatological disorders and inducing interferon biosynthesis with shorter durations of imiquimod therapy 0 2012
8,642,616 Lower dosage strength imiquimod formulations and short dosing regimens for treating genital and perianal warts 0 2012

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Oct 19, 2014
7.5 Year Payment $3600.00 $1800.00 $900.00 Oct 19, 2018
11.5 Year Payment $7400.00 $3700.00 $1850.00 Oct 19, 2022
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00