Liquid buffered GDF-5 formulations
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United States of America Patent
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May 24, 2011
Grant Date -
Oct 15, 2009
app pub date -
Apr 8, 2009
filing date -
Apr 14, 2008
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Abstract
Improved formulations and methods are provided for stabilizing a solution of bone morphogenetic protein. The compositions comprise an acetate buffered solution of GDF-5 and other excipients wherein the solution has a pH of from about 4.2 to about 5.3, thereby providing for a biologically isotonic solution having improved stability of the GDF-5 protein during storage, handling, and use.
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