Method of preparing non-human tissues for xenotransplantation using α-galactosidase
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United States of America Patent
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May 31, 2011
Grant Date -
Sep 3, 2009
app pub date -
Oct 31, 2006
filing date -
Oct 31, 2005
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Abstract
This invention relates to novel α-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family of α3 glycosidases, used for the enzymatic removal of type B antigens from blood group B and AB reactive blood products, and the GaIiIi antigen from non-human animal tissues, thereby converting these to non-immunogenic cells and tissues suitable for transplantation.
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