US Patent No: 7,968,119
Number of patents in Portfolio can not be more than 2000
Tamper-proof narcotic delivery system
Stats
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Jun 28, 2011
Issued date -
Jun 26, 2002
filing date -
10/183,678
serial no -
In Force
status
Importance
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Abstract
A composition for oral, transdermal or subdermal administration to a subject is described. The composition contains: (a) an agonist component; (b) an antagonist component containing at least one antagonist and having a delayed time of release; and (c) an immediate release antagonist removal component, where the subject includes a gastrointestinal tract and the antagonist removal component is present in an amount sufficient to substantially remove the antagonist component from the gastrointestinal tract of the subject before the time of release of the antagonist component. The composition may be delivered to the subject by a method which includes the step of administering the composition orally, transdermally or subdermally to the subject. When the composition of the present invention is administered orally, the method of the present invention may include the step of administering a potassium compound to the subject.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
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| 5,958,452 Extruded orally administrable opioid formulations | 75 | 1997 | |
| 6,228,863 Method of preventing abuse of opioid dosage forms | 69 | 1998 | |
| 6,277,384 Opioid agonist/antagonist combinations | 48 | 1998 | |
| 6,231,886 Methods of providing sustained treatment with opioids | 7 | 1999 | |
| 6,335,033 Melt-extrusion multiparticulates | 39 | 1999 | |
| 6,261,599 Melt-extruded orally administrable opioid formulations | 62 | 1999 | |
| 6,375,957 Opioid agonist/opioid antagonist/acetaminophen combinations | 59 | 2000 | |
| 6,696,088 Tamper-resistant oral opioid agonist formulations | 45 | 2001 | |
| 2002/0058,673 Opioid agonist/opioid antagonist/acetaminophen combinations | 21 | 2001 | |
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| 5,834,477 Opiate analgesic formulation with improved safety | 24 | 1994 | |
| 6,217,911 sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres | 22 | 1996 | |
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| 5,518,730 Biodegradable controlled release flash flow melt-spun delivery system | 144 | 1992 | |
| 6,013,280 Immediate release dosage forms containing microspheres | 17 | 1997 | |
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| 5,540,912 Viscous suspensions of controlled-release drug particles | 60 | 1994 | |
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| 6,130,258 Polyvalent metal cations in combination with dithiocarbamic acid compositions as board spectrum demulsifiers | 1 | 1998 | |
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| 5,855,915 Tablets or biologically acceptable implants for long-term antiinflammatory drug release | 15 | 1996 | |
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| 4,457,933 Prevention of analgesic abuse | 62 | 1981 | |
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| 4,391,797 Systems for the controlled release of macromolecules | 97 | 1981 | |
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| 5,840,332 Gastrointestinal drug delivery system | 52 | 1996 | |
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| 6,066,339 Oral morphine multiparticulate formulation | 7 | 1997 | |
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| 6,068,855 Pharmaceutical composition containing a fusible carrier and method for producing the same | 38 | 1997 | |
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| 6,020,002 Delivery of controlled-release system(s) | 14 | 1997 | |
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| 5,716,631 Long acting narcotic analgesics and antagonists | 6 | 1996 | |
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| 5,820,877 Percutaneously administrable patch preparation | 9 | 1996 | |
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| 5,317,022 Pharmaceutical composition and use | 39 | 1992 | |
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| 5,922,705 Rapid narcotic detoxification | 3 | 1998 | |
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| 5,569,467 Process for the preparation of microballs and microballs thus obtained | 14 | 1994 | |
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| 5,792,477 Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent | 73 | 1997 | |
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| 6,214,379 Maximizing effectiveness of substances used to improve health and well being | 14 | 1999 | |
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| 5,698,217 Transdermal drug delivery device containing a desiccant | 20 | 1995 | |
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| 5,679,373 Process of assembling a transdermal patch incorporating a polymer film incorporated with an active agent | 15 | 1995 | |
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| 6,326,027 Controlled release formulation | 37 | 1995 | |
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| 5,780,589 Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof | 12 | 1994 | |
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| 4,906,463 Transdermal drug-delivery composition | 65 | 1988 | |
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| 5,885,486 Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof | 13 | 1996 | |
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| 5,958,455 Oral solid dosage forms, methods of making same and compositions thereof | 23 | 1996 | |
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| 4,582,835 Analgesic compositions | 62 | 1984 | |
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| 5,783,583 17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol, hydrochloride salt for the purpose of rapid narcotic detoxification | 4 | 1996 | |
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| 5,496,561 Controlled release-initiation and controlled release-rate pharmaceutical composition | 15 | 1994 | |
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| 5,609,886 Microspheres for the controlled release of water-soluble substances and process for preparing them | 13 | 1995 | |
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| 6,310,072 Production of analgesic synergy by co-administration of sub-analgesic doses of a MU opioid agonist and a kappa-2 opioid agonist | 23 | 1997 | |
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| 4,987,136 Method for controlling gastrointestinal dysmotility | 80 | 1986 | |
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| 5,972,954 Use of methylnaltrexone and related compounds | 57 | 1997 | |
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| 5,494,677 Tissue-specific implantable therapeutic agent delivery system | 5 | 1993 | |
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| 5,709,883 Long acting narcotic analgesics and antagonists | 8 | 1997 | |
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| 5,580,569 Article for tissue-specific delivery of therapeutic agents | 10 | 1993 | |
| 5,512,587 Method for treating opiate withdrawal | 1 | 1994 | |
| 5,811,451 Pharmaceutical compositions comprising an opiate antagonist and calcium salts, their use for the treatment of endorphin-mediated pathologies | 16 | 1996 | |
| 5,919,473 Methods and devices for delivering opioid analgesics to wounds via a subdermal implant | 54 | 1997 | |
| 6,132,416 Universal medication dosing system | 11 | 1998 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 3.5 Year Payment | $1600.00 | $800.00 | $400.00 | Dec 28, 2014 |
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Dec 28, 2018 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Dec 28, 2022 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 3.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |