Production of functional antibodies in filamentous fungi
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United States of America Patent
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Jul 12, 2011
Grant Date -
Jul 21, 2005
app pub date -
Dec 9, 2004
filing date -
Apr 18, 2002
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Abstract
Described herein are methods for the production of monoclonal antibodies in filamentous fungi host cells. The monoclonal antibodies are expressed as full-length fusion proteins that retain functional antigen binding and antibody-dependent cellular cytotoxicity capabilities. Improvements in the cleavage of the glucoamylase-light chain fusion protein to yield a mature antibody are also provided. The antibodies produced in filamentous fungi show equivalent pharmacokinetic disposition to antibodies produced in mammalian cells.
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