Prevention and treatment of amyloidogenic diseases

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7977316
APP PUB NO 20080248023A1
SERIAL NO

11842046

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed are pharmaceutical compositions and methods for preventing or treating a number of amyloid diseases, including Alzheimer's disease, prion diseases, familial amyloid neuropathies and the like. The pharmaceutical compositions include immunologically reactive amounts of amyloid fibril components, particularly fibril-forming peptides or proteins. Also disclosed are therapeutic compositions and methods which use immune reagents that react with such fibril components.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ONCLAVE THERAPEUTICS LIMITEDDUBLIN, IE2

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Schenk, Dale B Burlingame, US 127 4308

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
2002/0009,445 Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease 100 2001
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SYNTEX, INCORPORATED (1)
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GLAXOSMITHKLINE LLC (1)
5854204 A.beta. peptides that modulate .beta.-amyloid aggregation 113 1996
 
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (1)
2003/0147,882 METHODS FOR AMYLOID REMOVAL USING ANTI-AMYLOID ANTIBODIES 55 1999
 
ELI LILLY AND COMPANY (7)
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5612486 Transgenic animals harboring APP allele having swedish mutation 141 1993
6114133 Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-.beta. peptide (x-.gtoreq.41) 105 1994
5593846 Methods for the detection of soluble .beta.-amyloid peptide 219 1995
5605811 Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein 91 1995
5837672 Methods and compositions for the detection of soluble .beta.-amyloid peptide 109 1995
6284221 Method for identifying .beta.-amyloid peptide production inhibitors 83 1996
 
TAKEDA PHARMACEUTICAL COMPANY LIMITED (2)
5750349 Antibodies to .beta.-amyloids or their derivatives and use thereof 149 1994
5955317 Antibodies to .beta.-amyloids or their derivatives and use thereof 98 1997
 
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (2)
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AMYLIN PHARMACEUTICALS, INC. (1)
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RASO, VICTOR (1)
2002/0136,718 Immunological control of beta-amyloid levels in vivo 63 2001
 
BRONSON NUTRITIONALS, LLC (5)
5869093 Treatment of immune diseases by oral administration of autoantigens 65 1994
5645820 Treatment of autoimmune diseases by aerosol administration of autoantigens 62 1995
5571499 Treatment of autoimmune diseases by aerosol administration of autoantigens 80 1995
5571500 Treatment of autoimmune diseases through administration by inhalation of autoantigens 63 1995
5641474 Prevention of autoimmune diseases by aerosol administration of autoantigens 60 1995
 
SCIOS NOVA INC. (3)
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5187153 Methods of treatment using Alzheimer's amyloid polypeptide derivatives 81 1990
5387742 Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease 195 1991
 
SUN HEALTH CORPORATION, INC. (1)
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PROTHENA BIOSCIENCES LIMITED (1)
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (3)
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5750361 Formation and use of prion protein (PRP) complexes 66 1995
 
AUTOIMMUNE, INC. (4)
5849298 Treatment of multiple sclerosis by oral administration of bovine myelin 51 1993
5869054 Treatment of multiple sclerosis by oral administration of autoantigens 56 1995
5733547 Treatment of autoimmune arthritis by oral administration of type I or type III collagen 54 1995
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Milkhaus Laboratory, Inc. (3)
5753624 Materials and methods for treatment of plaquing disease 89 1996
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5972269 Method of forming cavities in ceramic or metal injection molded parts using a fugitive core 16 1997
 
UNIVERSITY OF WASHINGTON (1)
5958883 Animal models of human amyloidoses 79 1995
 
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (1)
6417178 Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits 78 1997
 
TEKTRONIX, INC. (1)
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Andrulis Pharmaceuticals Corp. (1)
5434170 Method for treating neurocognitive disorders 97 1993
 
ABBVIE BIOTHERAPEUTICS INC. (1)
5622701 Cross-reacting monoclonal antibodies specific for E- and P-selectin 64 1994
 
ALZA CORPORATION (1)
5972369 Diffusional implantable delivery system 82 1998
 
BAYER PHARMACEUTICALS CORPORATION (1)
5786180 Monoclonal antibody 369.2B specific for .beta. A4 peptide 82 1995
 
ANTIGENICS INC. (2)
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ZOETIS SERVICES LLC (1)
5989566 Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation 54 1996
 
EPIMMUNE INC. (1)
5736142 Alteration of immune response using pan DR-binding peptides 83 1994
 
The Scripps Research Institute (1)
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MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
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HUNTINGTON POTTER (1)
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BHI LIMITED PARTNERSHIP (1)
5643562 Method for treating amyloidosis 40 1995
 
UNIVERSITY OF ROCHESTER (1)
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MCW RESEARCH FOUNDATION, INC. (1)
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5935927 Compositions and methods for stimulating amyloid removal in amyloidogenic diseases using advanced glycosylation endproducts 78 1996
 
PROTEIN DESIGN LABS, INC. (1)
5530101 Humanized immunoglobulins 1156 1990
 
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (1)
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SONORAN DESERT CHEMICALS CORP. LLC (1)
* 5290762 Treatment of inflammation 22 1993
 
PARDRIDGE, WILLIAM (1)
5004697 Cationized antibodies for delivery through the blood-brain barrier 101 1987
 
NEW YORK UNIVERSITY (1)
5948763 Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits 21 1996
 
CYTRX CORPORATION (1)
5824322 Compositions and methods for growth promotion 57 1996
 
REGENTS OF THE UNIVERSITY OF MINNESOTA (3)
5837473 Methods of screening for agents affecting the deposition of .beta.-amyloid peptides on amyloid plaques in human tissue 53 1995
5877399 Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease 121 1996
6262335 Transgenic mice expressing APP mutant at amino acids 717, 721 and 722 56 1998
 
CEDARS-SINAI MEDICAL CENTER (1)
5679348 Immunotherapy for recurrent HSV infections 52 1992
 
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (1)
5744368 Methods for the detection of soluble amyloid .beta.-protein (.beta.AP) or soluble transthyretin (TTR) 65 1993
 
TRUSTEES OF BOSTON UNIVERSITY (1)
5262303 Ligand/anti-ligand assays for adherent proteins 7 1990
 
NATIONAL RESEARCH COUNCIL OF CANADA (1)
* 5773007 Vaccine compositions 34 1994
 
SMITHKLINE BEECHAM BIOLOGICALS S.A. (1)
5776468 Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A 88 1996
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
BIOARCTIC NEUROSCIENCE AB (4)
8859501 Protofibril-binding antibodies and their use in thereapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies 2 2013
9315569 Antibodies and vaccines for use in therapeutic and diagnostic methods for α-synuclein-related disorders 0 2014
8968734 Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for Parkinson's disease, dementia with lewy bodies and other α-synucleinopathies 0 2014
9084832 Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other α-synucleinopathies 0 2015
* Cited By Examiner

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