Method of classifying human subjects having adolescent idiopathic scoliosis
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United States of America Patent
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Aug 2, 2011
Grant Date -
Apr 30, 2009
app pub date -
Sep 11, 2008
filing date -
Feb 28, 2002
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Abstract
A method for classifying human subjects having adolescent idiopathic scoliosis (AIS) into AIS subgroups, comprising detecting an impairment in the melatonin-signaling pathway in a cell sample from the subject, wherein the impairment is detected by an accumulation of cyclic adenosine 5′-monophosphate (cAMP) in the cell sample as compared to a control sample in the presence of a known melatonin-signaling pathway agonist, wherein the results of the detection step enable the classification of the subject having AIS into an AIS subgroup.
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