2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7989431
APP PUB NO 20090253647A1
SERIAL NO

12487235

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides compounds having the following general formula (I):

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
UNIVERSITY OF VIRGINIACHARLOTTESVILLE, VA383

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Figler, Robert Alan Earlysville, US 10 128
Linden, Joel M Charlottesville, US 36 715
Macdonald, Timothy L Charlottesville, US 61 480
Murphree, Lauren J Rockville, US 7 80
Rieger, Jayson M Charlottesville, US 49 580
Sullivan, Gail W Charlottesville, US 26 646

Cited Art Landscape

Patent Info (Count) # Cites Year
 
NOVARTIS CORPORATION (1)
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AMERICAN HOME PRODUCTS CORPORATION (1)
5124455 Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents 75 1990
 
MERCK FROSST CANADA LTD. (2)
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UNIVERSITY OF ROCHESTER, ROCHESTER, NEW YORK 14627, A NOT-FOR-PROFIT CORP. OF NEW YORK (1)
4938949 Treatment of damaged bone marrow and dosage units therefor 322 1988
 
SCHERING CORPORATION (1)
5593975 Adenosine derivatives having A.sub.2 agonist activity 59 1995
 
TOA EIYO LTD. (1)
6936596 Adenosine derivatives and use thereof 13 2001
 
PFIZER INC. (5)
6326359 Adenosine A2A receptor agonists as antiinflammatory agents 32 1999
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6525032 Purine derivatives 26 2001
6624158 Purine derivatives 14 2001
2003/0013,675 Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases 30 2002
 
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (2)
5298508 Irreversible inhibitors of adenosine receptors 33 1992
6545002 Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors 28 2000
 
PUREF, LLC (1)
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BIOCHEM PHARMA INC. (2)
5756706 Processes for the diastereoselective synthesis of nucleoside analogues 48 1994
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GLAXO WELLCOME INC. (1)
5776940 Phenylxanthine derivatives 27 1997
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
5668139 A1 adenosine receptor agonists and antagonists 22 1995
 
NEW YORK UNIVERSITY (2)
5932558 Adenosine receptor agonists for the promotion of wound healing 29 1996
6020321 Adenosine receptor agonists for the promotion of wound healing 25 1999
 
The University of Patent Foundation (1)
5854081 Stable expression of human A.sub.2B adenosine receptors, and assays employing the same 38 1996
 
UNIVERSITY OF VIRGINIA (23)
4965271 Method of inhibiting the activity of leukocyte derived cytokines 74 1987
5096906 Method of inhibiting the activity of leukocyte derived cytokines 80 1990
5272153 Method of inhibiting the activity of leukocyte derived cytokines 42 1992
5877180 Method for treating inflammatory diseases with A.sub.2a adenosine receptor agonists 72 1994
6117878 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors 60 1998
6303619 Meta-substituted acidic 8-phenylxanthine antagonists of A3 human adenosine receptors 30 1998
6060481 Method for improving insulin sensitivity using an adenosine receptor antagonist 26 1999
6322771 Induction of pharmacological stress with adenosine receptor agonists 47 1999
6448235 Method for treating restenosis with A2A adenosine receptor agonists 41 2000
6514949 Method compositions for treating the inflammatory response 41 2000
6531457 Methods and compositions for treating inflammatory response 32 2001
6670334 Method and compositions for treating the inflammatory response 32 2002
7214665 2-propynyl adenosine analogs having A.sub.2A agonist activity and compositions thereof 18 2002
7427606 Method to reduce inflammatory response in transplanted tissue 11 2004
* 7605143 agonist activity 10 2005
2006/0040,889 2-polycyclic propynyl adenosine analogs having A2A agonist activity 15 2005
* 7378400 Method to reduce an inflammatory response from arthritis 14 2005
2008/0009,460 METHOD TO TREAT SICKLE CELL DISEASE 12 2007
7737127 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof 5 2007
2007/0232,559 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF 9 2007
2009/0162,282 SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS 6 2008
2009/0298,788 2-POLYCYCLIC PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY 6 2009
2010/0152,127 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF 4 2010
 
ADERIS PHARMACEUTICALS, INC. (4)
5140015 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents 53 1990
5278150 2-hydrazoadenosines and their utility for the treatmeat of vascular conditions 44 1992
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6339072 Compositions and methods for preventing restenosis following revascularization procedures 20 2001
 
ICOS CORPORATION (1)
5665754 Substituted pyrrolidines 50 1993
 
BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (1)
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CARDIOKINE, INC. (1)
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PATENT FOUNDATION, VIRGINIA, UNIVERSITY OF (1)
6232297 Methods and compositions for treating inflammatory response 29 1999
 
Item Development AB (1)
5731296 Selective vasodilation by continuous adenosine infusion 40 1993
 
AKITA UNIVERSITY SCHOOL OF MEDICINE (1)
2008/0027,022 METHOD TO TREAT GASTRIC LESIONS 18 2007
 
TROVIS PHARMACEUTICALS, LLC (2)
2009/0162,292 SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS 10 2008
2009/0280,059 SUBSTITUTED ARYL PIPERIDINYLALKYNYLADENOSINES AS A2AR AGONISTS 8 2009
 
AVENTIS PHARMACEUTICALS PRODUCTS INC. (2)
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5593976 New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds 16 1995
 
YAMASA CORPORATION (1)
6387889 Medicinal compositions for treating eye diseases 19 2001
 
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5593973 Treatment of viral hepatitis with mismatched dsRNA 20 1994
 
SMITHKLINE BEECHAM CORPORATION (1)
6407076 Adenosine analogues and related method of treatment 17 2000
 
KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC. (1)
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Yamasa Shoyu Kabushiki Kaisha (2)
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TEVA PHARMACEUTICAL INDUSTRIES LTD. (1)
5565462 Composition for topical treatment of psoriasis and atopic dermatitis comprising a xanthine derivative 26 1994
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
UNIVERSITY OF VIRGINIA (5)
8178509 Method to treat sickle cell disease 0 2007
8188063 modulators to treat spinal cord injury 2 2007
* 2008/0064,653 USE OF ADENOSINE A2A MODULATORS TO TREAT SPINAL CORD INJURY 12 2007
8158604 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof 0 2010
* 2010/0152,127 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF 4 2010
* Cited By Examiner

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