US Patent No: 7,989,431

Number of patents in Portfolio can not be more than 2000

2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity

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ALSO PUBLISHED AS: 20090253647
ATTORNEY / AGENT: (SPONSORED)
 

Importance

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Abstract

The invention provides compounds having the following general formula (I):

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
UNIVERSITY OF VIRGINIACHARLOTTESVILLE, VA443

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Figler, Robert Alan Earlysville, VA 17 113
Linden, Joel M Charlottesville, VA 45 591
Macdonald, Timothy L Charlottesville, VA 74 322
Murphree, Lauren J Rockville, MD 11 68
Rieger, Jayson M Charlottesville, VA 73 345
Sullivan, Gail W Charlottesville, VA 32 567

Cited Art

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UNIVERSITY OF VIRGINIA (20)
5,272,153 Method of inhibiting the activity of leukocyte derived cytokines 42 1992
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6,117,878 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors 51 1998
6,303,619 Meta-substituted acidic 8-phenylxanthine antagonists of A3 human adenosine receptors 27 1998
6,060,481 Method for improving insulin sensitivity using an adenosine receptor antagonist 26 1999
6,322,771 Induction of pharmacological stress with adenosine receptor agonists 34 1999
6,448,235 Method for treating restenosis with A2A adenosine receptor agonists 32 2000
6,514,949 Method compositions for treating the inflammatory response 32 2000
6,531,457 Methods and compositions for treating inflammatory response 25 2001
6,670,334 Method and compositions for treating the inflammatory response 24 2002
7,214,665 2-propynyl adenosine analogs having A.sub.2A agonist activity and compositions thereof 17 2002
7,427,606 Method to reduce inflammatory response in transplanted tissue 11 2004
7,605,143 agonist activity 9 2005
2006/0040,889 2-polycyclic propynyl adenosine analogs having A2A agonist activity 10 2005
7,378,400 Method to reduce an inflammatory response from arthritis 13 2005
2008/0009,460 METHOD TO TREAT SICKLE CELL DISEASE 10 2007
7,737,127 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof 5 2007
2007/0232,559 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF 9 2007
2009/0162,282 SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS 6 2008
2010/0152,127 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF 4 2010
 
PFIZER INC. (5)
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6,525,032 Purine derivatives 21 2001
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5,561,134 Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties 31 1994
 
BIOCHEM PHARMA INC. (2)
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5,696,254 Processes for the diastereoselective synthesis of nucleoside analogues 41 1994
 
MERCK FROSST CANADA LTD. (2)
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NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (2)
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6,545,002 Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors 25 2000
 
NEW YORK UNIVERSITY (2)
5,932,558 Adenosine receptor agonists for the promotion of wound healing 28 1996
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TROVIS PHARMACEUTICALS, LLC (2)
2009/0162,292 SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS 7 2008
2009/0280,059 SUBSTITUTED ARYL PIPERIDINYLALKYNYLADENOSINES AS A2AR AGONISTS 8 2009
 
YAMASA SHOYU KABUSHIKI KAISHA (2)
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5,189,027 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases 49 1991
 
AKITA UNIVERSITY SCHOOL OF MEDICINE (1)
2008/0027,022 METHOD TO TREAT GASTRIC LESIONS 18 2007
 
AMERICAN HOME PRODUCTS CORPORATION (1)
5,124,455 Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents 75 1990
 
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BURROUGHS WELLCOME CO. (1)
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CARDIOKINE, INC. (1)
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GLAXO WELLCOME INC. (1)
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HEMISPHERX BIOPHARMA, INC. (1)
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ICOS CORPORATION (1)
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ITEM DEVELOPMENT AB (1)
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KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC. (1)
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NOVARTIS;CORPORATE INTELLECTUAL PROPERTY (1)
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PATENT FOUNDATION, VIRGINIA, UNIVERSITY OF (1)
6,232,297 Methods and compositions for treating inflammatory response 28 1999
 
PHARMACIA & UPJOHN S.P.A. (1)
5,593,976 New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds 16 1995
 
PUREF, LLC (1)
6,004,945 Use of adenosine compounds to relieve pain 24 1995
 
SCHERING AKTIENGESELLSCHAFT (1)
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SCHERING CORPORATION (1)
5,593,975 Adenosine derivatives having A.sub.2 agonist activity 52 1995
 
SMITHKLINE BEECHAM CORPORATION (1)
6,407,076 Adenosine analogues and related method of treatment 14 2000
 
TEVA PHARMACEUTICAL INDUSTRIES LTD. (1)
5,565,462 Composition for topical treatment of psoriasis and atopic dermatitis comprising a xanthine derivative 26 1994
 
THE UNIVERSITY OF PATENT FOUNDATION (1)
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TOA EIYO LTD. (1)
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UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
5,668,139 A1 adenosine receptor agonists and antagonists 22 1995
 
UNIVERSITY OF ROCHESTER, ROCHESTER, NEW YORK 14627, A NOT-FOR-PROFIT CORP. OF NEW YORK (1)
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UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION, THE, THE TOWERS OFFICE BUILDING, SUITE 6211, 1224 W. MAIN STREET, CHARLOTTESVILLE, VA 22903 A CORP OF VA (1)
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UNIVERSITY OF VIRGINIA PATENT FOUNDATION AND ADENOSINE THERAPEUTICS, L.L.C. (1)
2009/0298,788 2-POLYCYCLIC PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY 6 2009
 
UNIVERSITY OF VIRGINIA, A CORP. OF DE (1)
4,965,271 Method of inhibiting the activity of leukocyte derived cytokines 73 1987
 
WULFING; JOHANN A. (1)
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YAMASA CORPORATION (1)
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Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
UNIVERSITY OF VIRGINIA (3)
8,178,509 Method to treat sickle cell disease 0 2007
8,188,063 modulators to treat spinal cord injury 0 2007
8,158,604 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof 0 2010

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