Anti-myosin Va siRNA and skin depigmentation
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United States of America Patent
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Aug 16, 2011
Grant Date -
Sep 24, 2009
app pub date -
Dec 12, 2006
filing date -
Dec 12, 2005
priority date (Note) -
Expired
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Abstract
The present invention relates to novel isolated siRNAs comprising a sense RNA strand and a complementary antisense RNA strand which together form an RNA duplex, characterized in that the sense RNA strand comprises a sequence which has at most one nucleotide that is distinct in relation to a fragment of 14 to 30 contiguous nucleotides of the nucleotide sequence of exon F of the gene encoding the myosin Va protein, and also to compositions comprising at least one such siRNA, and to the use of at least one such siRNA as a cosmetic or therapeutic agent for skin depigmentation.
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