
US Patent No: 8,003,097
Number of patents in Portfolio can not be more than 2000
Treatment of cerebral amyloid angiopathy
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Aug 23, 2011
Issued date -
Jul 28, 2008
filing date -
12/181,238
serial no -
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Abstract
The invention provides improved agents and methods for treatment of cerebral amyloid angiopathy (CAA) and methods to effect prophylaxis of CAA. The methods can treat CAA concurrently with Alzheimer's disease or separately. The methods can effect prophylaxis of CAA concurrently with Alzheimer's disease or separately. The methods involve administering antibody that is specific for the N-terminus of Aβ or an agent that can induce such an antibody.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
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| 6,787,523 Prevention and treatment of amyloidogenic disease | 46 | 1998 | |
| 6,761,888 Passive immunization treatment of Alzheimer's disease | 56 | 2000 | |
| 6,913,745 Passive immunization of Alzheimer's disease | 38 | 2000 | |
| 6,710,226 Transgenic mouse assay to determine the effect of A.beta. antibodies and A.beta. Fragments on alzheimer's disease characteristics | 39 | 2000 | |
| 6,743,427 Prevention and treatment of amyloidogenic disease | 72 | 2000 | |
| 6,750,324 Humanized and chimeric N-terminal amyloid beta-antibodies | 46 | 2000 | |
| 6,787,138 Prevention and treatment of amyloidogenic disease | 37 | 2000 | |
| 6,787,139 Prevention and treatment of amyloidogenic disease | 34 | 2000 | |
| 6,787,140 Prevention and treatment of amyloidogenic disease | 36 | 2000 | |
| 6,787,143 Prevention and treatment of amyloidogenic disease | 30 | 2000 | |
| 6,787,144 Prevention and treatment of amyloidogenic disease | 37 | 2000 | |
| 6,787,637 N-Terminal amyloid-.beta. antibodies | 48 | 2000 | |
| 6,875,434 Methods of treatment of Alzheimer's disease | 36 | 2000 | |
| 6,890,535 Pharmaceutical compositions and methods for treatment of amyloid diseases | 32 | 2000 | |
| 6,905,686 Active immunization for treatment of alzheimer's disease | 33 | 2000 | |
| 7,575,880 Method of screening an antibody for activity in clearing an amyloid deposit | 8 | 2000 | |
| 7,588,766 Treatment of amyloidogenic disease | 8 | 2000 | |
| 2004/0081,657 Prevention and treatment of amyloidogenic disease | 28 | 2003 | |
| 2005/0059,802 Prevention and treatment of amyloidogenic disease | 23 | 2004 | |
| 2004/0265,308 Prevention and treatment of amyloidogenic disease | 28 | 2004 | |
| 6,808,712 Prevention and treatment of amyloidogenic disease | 25 | 2004 | |
| 6,818,218 Prevention and treatment of amyloidogenic disease | 27 | 2004 | |
| 6,866,849 Prevention and treatment of amyloidogenic disease | 37 | 2004 | |
| 6,866,850 Prevention and treatment of amyloidogenic disease | 35 | 2004 | |
| 6,982,084 Prevention and treatment of amyloidogenic disease | 20 | 2004 | |
| 7,014,855 Prevention and treatment of amyloidogenic disease | 29 | 2004 | |
| 2005/0019,328 Prevention and treatment of amyloidogenic disease | 20 | 2004 | |
| 2005/0059,591 Prevention and treatment of amyloidogenic disease | 20 | 2004 | |
| 2004/0219,146 Prevention and treatment of amyloidogenic disease | 21 | 2004 | |
| 6,962,707 Prevention and treatment of amyloidogenic disease | 28 | 2004 | |
| 2004/0247,591 Prevention and treatment of amyloidogenic disease | 15 | 2004 | |
| 2004/0265,301 Prevention and treatment of amyloidogenic disease | 16 | 2004 | |
| 2005/0158,304 Prevention and treatment of amyloidogenic disease | 15 | 2004 | |
| 2004/0247,590 Prevention and treatment of amyloidogenic disease | 16 | 2004 | |
| 2005/0013,815 Prevention and treatment of amyloidogenic disease | 22 | 2004 | |
| 2005/0019,330 Prevention and treatment of amyloidogenic disease | 36 | 2004 | |
| 2005/0048,049 Prevention and treatment of amyloidogenic disease | 20 | 2004 | |
| 2005/0191,292 Prevention and treatment of amyloidogenic disease | 15 | 2004 | |
| 2005/0249,727 Prevention and treatment of amyloidogenic disease | 20 | 2004 | |
| 2005/0196,399 Prevention and treatment of amyloidogenic disease | 16 | 2004 | |
| 2005/0163,788 Prevention and treatment of amyloidogenic disease | 20 | 2004 | |
| 2005/0255,122 Prevention and treatment of amyloidogenic disease | 20 | 2004 | |
| 6,946,135 Prevention and treatment of amyloidogenic disease | 27 | 2004 | |
| 6,972,127 Prevention and treatment of amyloidogenic disease | 35 | 2004 | |
| 2005/0142,132 Prevention and treatment of amyloidogenic disease | 21 | 2005 | |
| 2005/0191,314 Prevention and treatment of amyloidogenic disease | 23 | 2005 | |
| 2006/0029,611 Prevention and treatment of amyloidogenic disease | 18 | 2005 | |
| 2006/0034,858 Prevention and treatment of amyloidogenic disease | 18 | 2005 | |
| 2007/0154,480 Humanized antibodies that recognize beta amyloid peptide | 20 | 2006 | |
| 2008/0096,818 PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE | 19 | 2007 | |
| 2008/0221,306 HUMANIZED ANTIBODIES THAT RECOGNIZE BETA AMYLOID PEPTIDE | 7 | 2007 | |
| 2008/0227,718 PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE | 8 | 2007 | |
| 2008/0227,719 PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE | 6 | 2007 | |
| 2009/0069,544 HUMANIZED ANTIBODIES THAT RECOGNIZE BETA AMYLOID PEPTIDE | 9 | 2007 | |
| 2009/0191,231 PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE | 8 | 2007 | |
| 2009/0297,511 PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE | 9 | 2008 | |
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|
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| 7,189,819 Humanized antibodies that recognize beta amyloid peptide | 25 | 2001 | |
| 7,582,733 Humanized antibodies that recognize beta amyloid peptide | 10 | 2002 | |
| 7,179,892 Humanized antibodies that recognize beta amyloid peptide | 31 | 2003 | |
| 7,256,273 Humanized antibodies that recognize beta amyloid peptide | 30 | 2003 | |
| 2004/0171,815 Humanized antibodies that recognize beta amyloid peptide | 26 | 2003 | |
| 2004/0171,816 Humanized antibodies that recognize beta amyloid peptide | 20 | 2003 | |
| 2006/0188,512 Active immunization to generate antibodies to solble a-beta | 14 | 2004 | |
| 2004/0213,800 Active immunization to generate antibodies to soluble A-beta | 20 | 2004 | |
| 2005/0249,725 Humanized antibodies that recognize beta amyloid peptide | 22 | 2004 | |
| 2005/0118,651 Humanized antibodies that recognize beta amyloid peptide | 27 | 2004 | |
| 2007/0134,762 Immunogenic peptide carrier conjugates and methods of producing same | 19 | 2004 | |
| 2007/0161,088 Beta immunogenic peptide carrier conjugates and methods of producing same | 18 | 2004 | |
| 2006/0160,161 Methods for assessing antibodies to neurodegenerative disease-associated antigens | 19 | 2005 | |
| 2006/0153,772 Contextual fear conditioning for predicting immunotherapeutic efficacy | 14 | 2005 | |
| 2006/0198,851 Humanized Abeta antibodies for use in improving cognition | 24 | 2005 | |
| 2006/0240,486 Immunoprecipitation-based assay for predicting in vivo efficacy of beta-amyloid antibodies | 19 | 2005 | |
| 2006/0257,396 Abeta antibodies for use in improving cognition | 23 | 2005 | |
| 2006/0193,850 Anti a beta antibody formulation | 24 | 2006 | |
| 7,635,473 Anti Aβ antibody formulation | 6 | 2006 | |
| 2006/0280,743 Humanized antibodies that recognize beta amyloid peptide | 21 | 2006 | |
| 2007/0072,307 Methods of purifying Fc region containing proteins | 14 | 2006 | |
| 2007/0082,367 Methods of purifying anti a beta antibodies | 17 | 2006 | |
| 2008/0050,367 Humanized antibodies that recognize beta amyloid peptide | 15 | 2006 | |
| 2007/0238,154 Humanized antibodies that recognize beta-amyloid peptide | 15 | 2007 | |
| 2008/0145,373 A-BETA IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME | 15 | 2007 | |
| 2008/0281,082 HUMANIZED ANTIBODIES THAT RECOGNIZE BETA AMYLOID PEPTIDE | 5 | 2007 | |
| 2008/0299,074 A-BETA IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME | 7 | 2007 | |
| 2008/0279,873 ACTIVE IMMUNIZATION TO GENERATE ANTIBODIES TO SOLUBLE A-BETA | 8 | 2008 | |
| 2008/0292,625 PREVENTION AND TREATMENT OF CEREBRAL AMYLOID ANGIOPATHY | 8 | 2008 | |
| 2009/0142,270 PREVENTION AND TREATMENT OF CEREBRAL AMYLOID ANGIOPATHY | 12 | 2008 | |
| 2009/0155,256 Immunotherapy Regimes Dependent On APOE Status | 10 | 2008 | |
| 2010/0266,505 IMMUNOTHERAPY REGIMES DEPENDENT ON APOE STATUS | 4 | 2008 | |
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| 5,441,870 Methods for monitoring cellular processing of .beta.-amyloid precursor protein | 110 | 1992 | |
| 5,766,846 Methods of screening for compounds which inhibit soluble .beta.-amyloid peptide production | 118 | 1993 | |
| 5,612,486 Transgenic animals harboring APP allele having swedish mutation | 129 | 1993 | |
| 6,114,133 Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-.beta. peptide (x-.gtoreq.41) | 78 | 1994 | |
| 5,624,937 Chemical compounds as inhibitors of amyloid beta protein production | 56 | 1995 | |
| 5,593,846 Methods for the detection of soluble .beta.-amyloid peptide | 192 | 1995 | |
| 5,605,811 Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein | 70 | 1995 | |
| 5,721,130 Antibodies and fragments thereof which bind the carboxyl-terminus of an amino-terminal fragment of .beta.APP | 82 | 1995 | |
| 5,837,672 Methods and compositions for the detection of soluble .beta.-amyloid peptide | 99 | 1995 | |
| 6,284,221 Method for identifying .beta.-amyloid peptide production inhibitors | 59 | 1996 | |
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| 5,869,093 Treatment of immune diseases by oral administration of autoantigens | 58 | 1994 | |
| 5,645,820 Treatment of autoimmune diseases by aerosol administration of autoantigens | 55 | 1995 | |
| 5,571,499 Treatment of autoimmune diseases by aerosol administration of autoantigens | 67 | 1995 | |
| 5,571,500 Treatment of autoimmune diseases through administration by inhalation of autoantigens | 56 | 1995 | |
| 5,641,474 Prevention of autoimmune diseases by aerosol administration of autoantigens | 53 | 1995 | |
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| 5,385,887 Formulations for delivery of osteogenic proteins | 118 | 1993 | |
| 6,270,757 Formulations for IL-11 | 19 | 1994 | |
| 6,372,716 Formulations for factor IX | 17 | 1994 | |
| 5,770,700 Liquid factor IX formulations | 35 | 1996 | |
| 5,744,132 Formulations for IL-12 | 27 | 1997 | |
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| 4,912,206 CDNA clone encoding brain amyloid of alzheimer's disease | 33 | 1987 | |
| 5,472,693 Family of anti-carcinoembryonic antigen chimeric antibodies | 25 | 1993 | |
| 5,733,548 Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at least one other peptide, and their uses in vaccines and disease treatments | 25 | 1995 | |
| 2003/0068,316 Anti-ADDL antibodies and uses thereof | 45 | 2002 | |
| 2003/0166,557 SEMA3B inhibits tumor growth and induces apoptosis in cancer cells | 16 | 2002 | |
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| 4,666,829 Polypeptide marker for Alzheimer's disease and its use for diagnosis | 235 | 1985 | |
| 5,270,165 Method of diagnosis of amyloidoses | 70 | 1991 | |
| 5,464,823 Mammalian antibiotic peptides | 57 | 1993 | |
| 5,750,361 Formation and use of prion protein (PRP) complexes | 55 | 1995 | |
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| 5,849,298 Treatment of multiple sclerosis by oral administration of bovine myelin | 44 | 1993 | |
| 5,869,054 Treatment of multiple sclerosis by oral administration of autoantigens | 49 | 1995 | |
| 5,733,547 Treatment of autoimmune arthritis by oral administration of type I or type III collagen | 47 | 1995 | |
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| 5,753,624 Materials and methods for treatment of plaquing disease | 72 | 1996 | |
| 5,798,102 Treatment of cardiomyopathy | 18 | 1997 | |
| 5,851,996 Materials and methods for treatment of plaquing diseases | 77 | 1998 | |
| 6,294,171 Methods for treating disease states comprising administration of low levels of antibodies | 57 | 2001 | |
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| 6,582,945 Immunological control of .beta.-amyloid levels in vivo | 32 | 2000 | |
| 2002/0136,718 Immunological control of beta-amyloid levels in vivo | 55 | 2001 | |
| 2005/0147,613 Immunological control of beta-amyloid levels in vivo | 19 | 2005 | |
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| 5,817,626 Modulators of beta-amyloid peptide aggregation | 59 | 1995 | |
| 5,854,215 Modulators of .beta.-amyloid peptide aggregation | 51 | 1995 | |
| 5,854,204 A.beta. peptides that modulate .beta.-amyloid aggregation | 94 | 1996 | |
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| 6,303,567 Modulators of .beta.-amyloid peptide aggregation comprising D-amino acids | 58 | 1996 | |
| 5,985,242 Modulators of .beta.-amyloid peptide aggregation comprising D-amino acids | 53 | 1997 | |
| 2002/0133,001 Therapeutic agents and methods of use thereof for treating an amyloidogenic disease | 38 | 2001 | |
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| 5,837,473 Methods of screening for agents affecting the deposition of .beta.-amyloid peptides on amyloid plaques in human tissue | 46 | 1995 | |
| 5,877,399 Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease | 107 | 1996 | |
| 6,262,335 Transgenic mice expressing APP mutant at amino acids 717, 721 and 722 | 49 | 1998 | |
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| 5,220,013 DNA sequence useful for the detection of Alzheimer's disease | 65 | 1989 | |
| 5,187,153 Methods of treatment using Alzheimer's amyloid polypeptide derivatives | 69 | 1990 | |
| 5,387,742 Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease | 179 | 1991 | |
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| 4,879,213 Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse | 189 | 1986 | |
| 5,846,533 Antibodies specific for native PrP.sup.Sc | 67 | 1996 | |
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| 5,057,540 Saponin adjuvant | 139 | 1990 | |
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| 5,859,205 Humanised antibodies | 194 | 1994 | |
| 6,632,927 Humanized antibodies | 141 | 2001 | |
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| 5,652,334 Method for design of substances that enhance memory and improve the quality of life | 23 | 1993 | |
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| 6,331,440 Peptide binding the KLVFF-sequence of amyloid-.beta. | 30 | 1998 | |
| 2002/0094,335 Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases | 53 | 2001 | |
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| 6,713,450 Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid .beta. for induction of an immune response to amyloid .beta. and amyloid deposits | 27 | 2001 | |
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| 5,688,651 Prevention of protein aggregation | 80 | 1994 | |
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| 5,648,260 DNA encoding antibodies with altered effector functions | 162 | 1995 | |
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| 5,750,349 Antibodies to .beta.-amyloids or their derivatives and use thereof | 110 | 1994 | |
| 5,955,317 Antibodies to .beta.-amyloids or their derivatives and use thereof | 72 | 1997 | |
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Patent Citation Ranking
Maintenance Fees
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| 3.5 Year Payment | $1600.00 | $800.00 | $400.00 | Feb 23, 2015 |
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