US Patent No: 8,007,992

Number of patents in Portfolio can not be more than 2000

alcohol

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ALSO PUBLISHED AS: 20080102439
ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

alcohol and removing a portion of the treatment solution from the solution-treated biological tissue. Also disclosed is biological tissue prepared using the above process and prosthetic devices made with such tissue.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
EDWARDS LIFESCIENCES CORPORATIONIRVINE, CA772

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davidson, Jim - 18 63
Tian, Bin San Diego, CA 34 32

Cited Art

Patent Info (Count) # Cites Year
 
EDWARDS LIFESCIENCES CORPORATION (18)
4,481,009 Polymer incorporation into implantable biological tissue to inhibit calcification 29 1982
4,648,881 Implantable biological tissue and process for preparation thereof 111 1982
4,647,283 Implantable biological tissue and process for preparation thereof 86 1984
5,215,541 Surfactant treatment of implantable biological tissue to inhibit calcification 52 1985
4,770,665 Elastomeric polymer incorporation into implantable biological tissue to inhibit calcification 30 1985
4,885,005 Surfactant treatment of implantable biological tissue to inhibit calcification 47 1987
4,838,888 Calcification mitigation of implantable bioprostheses 40 1987
5,002,566 Calcification mitigation of bioprosthetic implants 54 1989
6,561,970 Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods 12 1996
5,928,281 Tissue heart valves 101 1997
5,931,969 Methods and apparatuses for treating biological tissue to mitigate calcification 31 1997
5,769,780 Method of manufacturing natural tissue valves having variably compliant leaflets 27 1997
6,008,292 Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials 15 1997
5,935,168 Glutaraldehyde-fixed bioprostheses 11 1998
6,214,054 Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby 14 1998
6,210,957 Apparatuses for treating biological tissue to mitigate calcification 12 1999
6,547,827 Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby 21 2001
2006/0217,805 Treatment of bioprosthetic tissues to mitigate post implantation calcification 4 2006
 
ST. JUDE MEDICAL, INC. (13)
6,203,755 Electron beam sterilization of biological tissues 11 1994
6,121,041 Use of microorganisms for decellularizing bioprosthetic tissue 5 1996
6,302,909 Calcification-resistant biomaterials 6 1996
5,855,620 Matrix substrate for a viable body tissue-derived prosthesis and method for making the same 39 1996
6,206,917 Differential treatment of prosthetic devices 15 1997
6,193,749 Calcification-resistant biomaterials 13 1997
6,254,635 Calcification-resistant medical articles 14 1998
6,132,473 Differential treatment of prosthetic devices 40 1998
6,375,680 Substrates for forming synthetic tissues 6 1998
6,190,407 Medical article with adhered antimicrobial metal 46 1998
6,471,723 Biocompatible prosthetic tissue 29 2000
6,531,310 Use of microorganisms for processing bioprosthetic tissue 4 2000
6,468,660 Biocompatible adhesives 30 2000
 
LIFENET HEALTH (12)
5,556,379 Process for cleaning large bone grafts and bone grafts produced thereby 39 1995
6,024,735 Process and composition for cleaning soft tissue grafts optionally attached to bone and soft tissue and bone grafts produced thereby 18 1997
6,293,970 Plasticized bone and soft tissue grafts and methods of making and using same 33 1998
6,734,018 Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced 23 2000
6,569,200 Plasticized soft tissue grafts, and methods of making and using same 11 2001
6,544,289 Plasticized bone grafts, and methods of making and using same 13 2001
2003/0083,752 Plasticized bone and soft tissue grafts and methods of making and using same 5 2001
7,063,726 Plasticized bone grafts and methods of making and using same 5 2002
2003/0217,415 Plasticized bone grafts and methods of making and using same 10 2003
7,338,757 Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced 4 2003
2005/0246,035 Plasticized bone and soft tissue grafts and methods of making and using same 5 2005
2009/0041,729 Process for Decellularizing Soft-Tissue Engineered Medical Implants, and Decellularized Soft-Tissue Medical Implants Produced 4 2008
 
SULZER CARBOMEDICS INC. (9)
6,093,530 Non-calcific biomaterial by glutaraldehyde followed by oxidative fixation 31 1998
6,156,531 Cross-linking tissue with a compound having a C.sub.8 to C.sub.40 aliphatic chain 16 1998
6,287,338 Pre-stressing devices incorporating materials subject to stress softening 19 1999
6,177,514 Blocked functional reagants for cross-linking biological tissues 32 1999
6,322,593 Method for treating cross-linked biological tissues 22 1999
6,132,986 Tissue crosslinking for bioprostheses using activated difunctional or polyfunctional acids 20 1999
6,364,905 Tri-composite, full root, stentless valve 24 1999
6,479,079 Anticalcification treatments for fixed biomaterials 21 1999
2002/0111,532 Tris(hydroxymethyl)phosphino compounds as tissue crosslinking agents 6 2000
 
APERION BIOLOGICS, INC. (8)
5,865,849 Meniscal heterografts 39 1995
5,782,915 Articular cartilage heterografts 44 1997
5,913,900 Substantially native meniscal cartilage heterografts 21 1997
5,922,027 Articular cartilage heterografts 33 1997
6,093,204 Meniscal heterografts 41 1998
6,231,608 Aldehyde and glycosidase-treated soft and bone tissue xenografts 34 1999
6,267,786 Proteoglycan-reduced soft tissue xenografts 27 1999
6,383,732 Method of preparing xenograft heart valves 20 2000
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (8)
5,094,661 Calcification-resistant materials and methods of making same through use of trivalent aluminum 41 1988
5,368,608 Calcification-resistant materials and methods of making same through use of multivalent cations 40 1991
5,296,583 Calcification-resistant synthetic biomaterials 18 1992
5,746,775 Method of making calcification-resistant bioprosthetic tissue 28 1993
5,436,291 Calcification-resistant synthetic biomaterials 25 1994
5,679,112 Calcification-resistant materials and methods of making same through use of multivalent cations 22 1994
5,674,298 Calcification-resistant bioprosthetic tissue and methods of making same 45 1995
6,448,076 Method for chemically acellularizing a biological tissue sample 16 2001
 
CRYOLIFE, INC. (7)
5,149,621 Kit for cryopreserving blood vessels 10 1990
5,613,982 Method of preparing transplant tissue to reduce immunogenicity upon implantation 86 1995
5,632,778 Treated tissue for implantation and methods of preparation 77 1995
5,899,936 Treated tissue for implantation and methods of preparation 73 1995
5,843,182 Treated tissue for implantation and methods of preparation 26 1997
2001/0000,804 Tissue decellularization 10 2000
7,318,998 Tissue decellularization 21 2003
 
BIOMEDICAL DESIGN, INC. (6)
4,976,733 Prevention of prosthesis calcification 76 1989
5,447,536 Method for fixation of biological tissue 53 1994
5,733,339 Process for fixation of calcification-resistant biological tissue 25 1996
5,911,951 Method of sterilization 18 1998
6,506,339 Method of sterilization 9 1999
2006/0159,641 VARIABLY CROSSLINKED TISSUE 5 2006
 
LIFECELL CORPORATION (6)
5,336,616 Method for processing and preserving collagen-based tissues for transplantation 151 1993
6,933,326 Particulate acellular tissue matrix 24 1999
2003/0035,843 Method for processing and preserving collagen-based tissues for transplantation 15 2002
2006/0073,592 Methods of storing tissue matrices 7 2004
7,358,284 Particulate acellular tissue matrix 15 2005
2006/0210,960 Method for processing and preserving collagen-based tissues for transplantation 10 2005
 
MEDTRONIC, INC. (6)
4,323,358 Method for inhibiting mineralization of natural tissue during implantation 67 1981
4,402,697 Method for inhibiting mineralization of natural tissue during implantation 40 1982
4,405,327 Method for inhibiting mineralization of natural tissue during implantation 36 1982
6,117,979 Process for making a bioprosthetic device and implants produced therefrom 136 1997
6,509,145 Process for reducing mineralization of tissue used in transplantation 25 2001
2004/0030,381 Heart valve prosthesis 71 2003
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (5)
4,676,070 Apparatus and method for cryopreparing biological tissue 24 1985
4,865,871 Method for cryopreparing biological tissue 75 1988
5,024,830 Method for cryopreparing biological tissue for ultrastructural analysis 29 1988
5,044,165 Cryo-slammer 63 1988
5,154,007 Method and apparatus for cryopreparing biological tissue 9 1990
 
HANCOCK JAFFE LABORATORIES (4)
5,595,571 Biological material pre-fixation treatment 60 1994
5,720,777 Biological material pre-fixation treatment 32 1995
5,843,180 Method of treating a mammal having a defective heart valve 38 1997
5,843,181 Biological material pre-fixation treatment 60 1997
 
CARBOMEDICS INC. (3)
5,437,287 Sterilization of tissue implants using iodine 21 1992
6,797,000 Tri-composite, full root, stentless valve 47 2002
2006/0110,370 Treatments for reduction of cytotoxicity and viral contamination of implantable medical devices 1 2004
 
CHILDREN'S MEDICAL CENTER CORPORATION (3)
4,753,652 Biomaterial implants which resist calcification 166 1986
6,376,244 Methods and compositions for organ decellularization 52 1999
6,753,181 Methods and compositions for organ decellularization 12 2002
 
SYNOVIS LIFE TECHNOLOGIES, INC. (3)
5,782,914 Method for preparing heterogeneous tissue grafts 42 1996
6,312,474 Resorbable implant materials 92 1999
6,652,594 Resorbable implant materials 66 2002
 
WARSAW ORTHOPEDIC, INC. (3)
5,290,558 Flowable demineralized bone powder composition and its use in bone repair 126 1990
5,298,254 Shaped, swollen demineralized bone and its use in bone repair 173 1991
5,507,813 Shaped materials derived from elongate bone particles 240 1993
 
APERION BIOLOGICS, IINC. (2)
5,902,338 Anterior cruciate ligament heterograft 30 1995
6,063,120 Anterior cruciate ligament heterograft 6 1998
 
BEIERSDORF AG (2)
4,831,065 Antithrombogenic, non-calcifying material and method of making articles for medical purposes 11 1986
4,996,054 Antithrombogenic, non-calcifying material and method of making articles for medical purposes 46 1988
 
GRANDHOPE BIOTECH CO., LTD. (2)
6,106,555 Method for tissue fixation 14 1998
6,231,614 Method for tissue fixation 6 2000
 
RTI BIOLOGICS, INC. (2)
6,613,278 Tissue pooling process 27 1999
7,648,676 Process and apparatus for treating implants comprising soft tissue 5 2004
 
THE PROCTER & GAMBLE COMPANY (2)
5,011,913 Diphosphonate-derivatized macromolecules 12 1989
5,068,100 Anticalculus compositions 4 1990
 
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (2)
5,147,514 Process for cross-linking collagenous material and resulting product 39 1990
5,332,475 Cross-linking collagenous product 40 1992
 
UNIVERSITY OF CONNECTICUT (2)
6,586,573 Albumin-free Factor VIII formulations 31 2000
7,087,723 Albumin-free factor VIII formulations 10 2003
 
W. L. GORE & ASSOCIATES, INC. (2)
5,762,600 Blood contact surfaces employing natural subendothelial matrix and methods for making and using the same 29 1996
5,776,182 Blood contact surfaces employing natural subendothelial matrix and method for making and using the same 19 1996
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (2)
6,653,062 Preservation and storage medium for biological materials 5 2000
6,919,172 Preservation and storage medium for biological materials 5 2003
 
3F THERAPEUTICS, INC. (1)
7,594,974 Method of cutting material for use in implantable medical device 7 2004
 
ACELL, INC. (1)
6,893,666 Tissue regenerative composition, method of making, and method of use thereof 12 2002
 
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (1)
5,476,516 Anticalcification treatment for aldehyde-tanned biological tissue 28 1992
 
AMERICAN AXLE & MANUFACTURING, INC. (1)
5,879,383 Blood contact surfaces using endothelium on a subendothelial matrix 42 1997
 
AMRESCO, INC. (1)
5,977,153 Solid aldehyde and antimicrobial compositions useful as fixatives, preservatives and embalming agents 10 1997
 
ANGIOTECH PHARMACEUTICALS, INC. (1)
7,176,256 Biocompatible crosslinked composition 5 2004
 
B. BRAUN-SSC AG (1)
4,357,274 Process for the manufacture of sclero protein transplants with increased biological stability 47 1981
 
BAXTER INTERNATIONAL INC. (1)
4,599,084 Method of using biological tissue to promote even bone growth 95 1983
 
BAXTER TRAVENOL LABORATORIES, INC. (1)
4,786,287 Process for decreasing residual aldehyde levels in implantable bioprosthetic tissue 32 1986
 
BAYLOR COLLEGE OF MEDICINE (1)
6,589,591 Method for treating medical devices using glycerol and an antimicrobial agent 5 2001
 
BIOMERIEUX, INC. (1)
5,856,172 Preservation of microorganisms in a vial with a cap comprising an immobilized desiccant 22 1997
 
BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC. (1)
5,200,399 Method of protecting biological materials from destructive reactions in the dry state 58 1991
 
CHILDREN'S HOSPITAL OF PHILADELPHIA (1)
6,391,538 Stabilization of implantable bioprosthetic tissue 25 2000
 
CLEARANT, INC. (1)
6,908,591 Methods for sterilizing biological materials by irradiation over a temperature gradient 88 2002
 
COLIBRI HEART VALVE LLC (1)
2005/0113,910 Percutaneously implantable replacement heart valve device and method of making same 104 2004
 
COLLAGEN AESTHETICS, INC. (1)
5,292,802 Collagen-polymer tubes for use in vascular surgery 138 1992
 
CORAZON (1)
6,394,096 Method and apparatus for treatment of cardiovascular tissue mineralization 26 1998
 
CORDIS CORPORATION (1)
6,527,979 Catheter systems and methods for their use in the treatment of calcified vascular occlusions 32 1999
 
DAIDALOS SOLUTIONS B.V. (1)
6,790,229 Fixing device, in particular for fixing to vascular wall tissue 134 2002
 
DISCOVERY LABWARE, INC. (1)
5,108,923 Bioadhesives for cell and tissue adhesion 16 1987
 
DOW CORNING WRIGHT CORPORATION, ARLINGTON, TENNESSEE (1)
4,378,224 Coating for bioprosthetic device and method of making same 112 1980
 
FTS SYSTEMS, INC. (1)
4,197,658 Tissue freeze dryer 13 1978
 
GE.SV.IN. S.R.1. - A CORP. OF ITALY (1)
4,655,773 Bicuspid valve prosthesis for an auriculo-ventricular cardiac aperture 28 1985
 
GENENTECH, INC. (1)
6,685,940 Protein formulation 45 2001
 
GENETIX LIMITED (1)
6,322,994 Method of freeze-drying organisms 6 1999
 
GRAIN PROCESSING CORPORATION (1)
6,828,310 Compositions including reduced malto-oligosaccharide preserving agents, and methods for preserving a material 4 2003
 
HARBOR MEDICAL DEVICES, INC. (1)
5,447,724 Medical device polymer 365 1993
 
HSC RESEARCH DEVELOPMENT CORPORATION (1)
4,776,853 Process for preparing biological mammalian implants 110 1987
 
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (1)
4,958,008 Process for crosslinking of collagen by introduction of azide groups as well as tissues and biomaterials obtained by use of the process 13 1988
 
INTERNATIONAL HEART INSTITUTE OF MONTANA FOUNDATION, THE (1)
6,277,555 Compliant dehydrated tissue for implantation and process of making the same 85 2000
 
KERNFORSCHUNGSANLAGE JULICH GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (1)
4,347,671 Vacuum-drying method and apparatus 23 1980
 
KOKEN CO., LTD. (1)
5,080,670 Bioprosthetic valve 39 1988
 
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (1)
5,697,972 Bioprosthetic heart valves having high calcification resistance 33 1995
 
LATHAM, DANIEL W. (1)
5,509,932 Fixed tissue medical devices comprising albumin-binding dyes 19 1993
 
LEEDS UNIVERSITY (1)
7,354,749 Decellularisation of matrices 4 2002
 
M&I MARSHALL & ILSLEY BANK (1)
2006/0177,426 Method of preserving lyophilized microorganisms for transport, storage and recovery of viable microorganisms 4 2006
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (1)
4,553,974 Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor 88 1984
 
MITROFLOW INTERNATIONAL, INC. (1)
5,862,806 Borohydride reduction of biological tissues 9 1997
 
MURES CARDIOVASCULAR RESEARCH, INC. (1)
6,214,055 Method and kit for rapid preparation of autologous tissue medical devices 34 1998
 
NATIONAL UNIVERSITY OF SINGAPORE (1)
5,882,850 Method for reducing calcification of biological tissue used implantable bioprostheses 10 1997
 
ONE BAXTER PARKWAY (1)
5,782,931 Methods for mitigating calcification and improving durability in glutaraldehyde-fixed bioprostheses and articles manufactured by such methods 16 1996
 
ORGANOGENESIS, INC. (1)
5,460,962 Peracetic acid sterilization of collagen or collagenous tissue 115 1994
 
OSTEOTECH INVESTMENT CORPORATION (1)
4,994,030 Reconstitution of human bone and tissue 34 1988
 
PERSING, DAVID H. (1)
6,258,320 Method for preservation of nucleic acids 18 1998
 
PROVIDENCE HEALTH SYSTEM, INC. (1)
6,372,228 Method of producing elastin, elastin-based biomaterials and tropoelastin materials 20 1997
 
QDOSE LIMITED (1)
6,290,991 Solid dose delivery vehicle and methods of making same 51 1994
 
QUADRANT BIORESOURCES LIMITED (1)
4,891,319 Protection of proteins and the like 153 1987
 
QUADRANT BIORESOURCES LIMITED, CAMBRIDGE RESEARCH LABORATORIES, 181A HUNTINGDON ROAD, CAMBRIDGE, CB3 ODJ, GREAT BRITAIN (1)
5,149,653 Preservation of viruses 71 1989
 
QUADRANT DRUG DELIVERY LIMITED (1)
6,586,006 Solid delivery systems for controlled release of molecules incorporated therein and methods of making same 30 2001
 
QUEEN'S UNIVERSITY AT KINGSTON (1)
4,207,689 Preservation of animal specimens 9 1978
 
QUEEN'S UNIVERSITY OF KINGSTON, A CORP. OF CANADA (1)
4,328,256 Preservation of green plant tissues 15 1981
 
QUICKIE, LLC (1)
6,066,160 Passive knotless suture terminator for use in minimally invasive surgery and to facilitate standard tissue securing 156 1998
 
ROBERT BOSCH GMBH (1)
5,904,718 Delayed drug delivery system 32 1997
 
SCICAN LTD. (1)
5,424,047 Sterilization of medical instruments, implants and the like 22 1994
 
SOCIETE SEDATELEC, A CORP OF FRANCE (1)
4,729,139 Selective incorporation of a polymer into implantable biological tissue to inhibit calcification 21 1985
 
SORIN BIOMEDICA CARDIO S.P.A. (1)
5,873,812 Method of preparing biological implantation material 7 1997
 
STRYKER CORPORATION (1)
4,975,526 Bone collagen matrix for zenogenic implants 106 1989
 
SULZER BIOLOGIES, INC. (1)
6,328,762 Prosthetic grafts 28 1999
 
TEI BIOSCIENCES, INC. (1)
6,696,074 Processing fetal or neo-natal tissue to produce a scaffold for tissue engineering 15 2001
 
THE BETH ISRAEL HOSPITAL ASSOCIATION (1)
4,994,237 Microwave preservation of bioprostheses 25 1989
 
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (1)
6,660,265 Fresh, cryopreserved, or minimally cardiac valvular xenografts 6 2000
 
THE CLEVELAND CLINIC FOUNDATION (1)
6,534,004 Processing of implantable animal tissues for dry storage 9 2000
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
4,294,753 Bone morphogenetic protein process 216 1980
 
TISSUE SCIENCE LABORATORIES, LTD. (1)
5,397,353 Implant tissue 31 1991
 
TOPPAN PRINTING CO., LTD. (1)
4,206,844 Package for a sterilized material 62 1978
 
UNIVERSAL PRESERVATION TECHNOLOGIES, INC. (1)
5,766,520 Preservation by foam formation 34 1997
 
UNIVERSITY OF SOUTH ALABAMA (1)
5,051,401 Inhibition of mineral deposition by phosphorylated and related polyanionic peptides 28 1989
 
UNIVERSITY OF SOUTHERN CALIFORNIA (1)
5,104,405 Process for improving the biostability of tissue implant devices and bioprosthetic implants so produced 34 1991
 
YAMAMOTO, RUTH S. (1)
5,987,720 Portable tomb for resurrection from mummified tissue DNA 22 1997
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (6)
5,558,875 Method of preparing collagenous tissue 15 1994
5,645,587 Prevention of calcification and degeneration of biological tissue grafts for implantation in humans 20 1996
5,856,102 Home/self-storage to improve DNA banking 13 1997
6,582,464 Biomechanical heart valve prosthesis and method for making same 5 2001
7,008,763 Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue 6 2002
2004/0193,259 Sizing apparatus for cardiac prostheses and method of using same 31 2003

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
COLIBRI HEART VALVE LLC (1)
8,361,144 Percutaneously deliverable heart valve and methods associated therewith 0 2011
 
EDWARDS LIFESCIENCES CORPORATION (1)
8,357,387 Capping bioprosthetic tissue to reduce calcification 0 2008

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