Prodrugs of CC-A1065 analogs
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United States of America Patent
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Sep 6, 2011
Grant Date -
Jan 29, 2009
app pub date -
Sep 4, 2008
filing date -
Mar 7, 2006
priority date (Note) -
Expired
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Abstract
The present invention provides prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group containing a sulfonic acid containing phenyl carbamate, in which the protecting group confers enhanced water solubility upon the prodrug, and in which the prodrug also has a moiety, such as a sulfide or a disulfide, that can conjugate to a cell binding reagent such as an antibody, and for the therapeutic use of such prodrug and conjugates, and for processes for preparing such prodrugs and conjugates.
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