US Patent No: 8,017,146
Number of patents in Portfolio can not be more than 2000
Transdermal delivery system with two superimposed adhesive layers having different affinities to the active substance comprised
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Sep 13, 2011
Issued date -
May 15, 2003
filing date -
10/514,047
serial no -
In Force
status
Importance
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Abstract
A device for the transdermal delivery of a pharmacologically active substance has first and second superimposed mutually contacting adhesive layers (2, 3). The first layer (3) is in use brought into contact with the skin. The active substance is dissolved in both layers, the affinity of the first layer for the active substance being between about 1.15 and about 10 times lower than that of the second layer. The percent saturation of the active substance in both the layers is the same and is less than 100%. The first layer has a greater thickness than the second layer. The device is simple and can provide stable delivery over a long period.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,262,003 Method and therapeutic system for administering scopolamine transdermally | 33 | 1977 | |
| 4,286,592 Therapeutic system for administering drugs to the skin | 174 | 1980 | |
| 4,436,741 Method for administering scopolamine transdermally | 8 | 1983 | |
| 4,938,759 Transdermal delivery device having a rate controlling adhesive | 44 | 1986 | |
| 5,004,610 Subsaturated nicotine transdermal therapeutic system | 44 | 1990 | |
| 6,174,545 Drug delivery devices and process of manufacture | 1 | 1999 | |
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| 5,474,783 Solubility parameter based drug delivery system and method for altering drug saturation concentration | 107 | 1991 | |
| 5,656,286 Solubility parameter based drug delivery system and method for altering drug saturation concentration | 132 | 1994 | |
| 5,958,446 Solubility parameter based drug delivery system and method for altering drug saturation concentration | 44 | 1995 | |
| 6,235,306 Solubility parameter based drug delivery system and method for altering drug saturation concentration | 18 | 1999 | |
| 6,221,383 Solubility parameter based drug delivery system and method for altering drug saturation concentration | 39 | 1999 | |
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| 5,230,898 Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof | 38 | 1990 | |
| 6,074,665 Transdermal therapeutic system for administering active agents to the human body via the skin | 3 | 1998 | |
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| 4,201,211 Therapeutic system for administering clonidine transdermally | 122 | 1977 | |
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| 5,006,342 Resilient transdermal drug delivery device | 70 | 1989 | |
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| 6,024,976 Solubility parameter based drug delivery system and method for altering drug saturation concentration | 63 | 1997 | |
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| 5,310,559 Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer | 32 | 1992 | |
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| 5,662,926 Transdermal patch incorporating a polymer film incorporated with an active agent | 16 | 1995 | |
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| 4,906,463 Transdermal drug-delivery composition | 65 | 1988 | |
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| 4,769,028 Pharmaceutical product, in medical bandage form | 33 | 1986 | |
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| 2004/0202,704 Transdermal delivery systems and methods | 2 | 2003 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 3.5 Year Payment | $1600.00 | $800.00 | $400.00 | Mar 13, 2015 |
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Mar 13, 2019 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Mar 13, 2023 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 3.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |