Reversible di-nucleotide terminator sequencing
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United States of America Patent
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Sep 13, 2011
Grant Date -
Oct 22, 2009
app pub date -
Nov 20, 2008
filing date -
Nov 20, 2007
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Abstract
The present teachings provide methods, compositions, and kits for synthesizing and sequencing nucleic acids. In some embodiments, reversible di-nucleotide compounds are employed along with cleaving reactions that remove a label and a blocking moiety. Improved sequencing efficiency is achieved by the rapid polymerase-mediated incorporation of reversible di-nucleotide compounds. In some embodiments, the di-nucleotides do not contain conventional nucleotide triphosphates, but rather employ amino acid phosphoramidate nucleotides (AAPNs).
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