US Patent No: 8,017,598

Number of patents in Portfolio can not be more than 2000

Compositions of R(+) and S(−) pramipexole and methods of using the same

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ALSO PUBLISHED AS: 20080014259
ATTORNEY / AGENT: (SPONSORED)
 

Importance

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Abstract

Compositions of predetermined amounts of R(+) pramipexole and S(−) pramipexole and methods of using the same, including for the treatment and prevention of Parkinson's disease, are provided.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
KNOPP NEUROSCIENCES, INC.PITTSBURGH, PA2

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bozik, Michael E Pittsburgh, PA 12 12
Gribkoff, Valentin Wallingford, CT 8 9
Petzinger,, JR Thomas - 8 6

Cited Art

Patent Info (Count) # Cites Year
 
ALZA CORPORATION (42)
4,286,592 Therapeutic system for administering drugs to the skin 176 1980
4,314,557 Dissolution controlled active agent dispenser 103 1980
4,327,725 Osmotic device with hydrogel driving member 547 1980
4,379,454 Dosage for coadministering drug and percutaneous absorption enhancer 212 1981
4,725,272 Novel bandage for administering beneficial drug 34 1981
4,435,180 Elastomeric active agent delivery system and method of use 73 1982
4,559,222 Matrix composition for transdermal therapeutic system 91 1983
4,704,282 Transdermal therapeutic system having improved delivery characteristics 79 1984
4,588,580 Transdermal administration of fentanyl and device therefor 163 1984
4,568,343 Skin permeation enhancer compositions 151 1984
4,573,995 Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine 104 1984
4,612,008 Osmotic device with dual thermodynamic activity 226 1984
4,645,502 Transdermal delivery of highly ionized fat insoluble drugs 76 1985
4,698,062 Medical device for pulsatile transdermal delivery of biologically active agents 35 1985
4,938,759 Transdermal delivery device having a rate controlling adhesive 46 1986
4,908,027 Subsaturated transdermal therapeutic system having improved release characteristics 56 1986
4,783,337 Osmotic system comprising plurality of members for dispensing drug 174 1986
4,904,475 Transdermal delivery of drugs from an aqueous reservoir 38 1987
4,788,062 Transdermal administration of progesterone, estradiol esters, and mixtures thereof 68 1987
4,816,258 Transdermal contraceptive formulations 67 1987
4,781,924 Transdermal drug delivery device 44 1987
4,849,226 Method for increasing oxygen supply by administering vasodilator 45 1987
4,917,895 Transdermal drug delivery device 36 1988
5,071,656 Delayed onset transdermal delivery device 41 1988
5,141,750 Delayed onset transdermal delivery device 37 1988
5,024,843 Oral hypoglycemic glipizide granulation 36 1989
5,004,610 Subsaturated nicotine transdermal therapeutic system 45 1990
5,082,668 Controlled-release system with constant pushing source 52 1990
5,545,413 Dosage form for administering oral hypoglycemic glipizide 14 1991
5,091,190 Delivery system for administration blood-glucose lowering drug 31 1991
5,284,660 Delayed onset transdermal delivery device 22 1992
5,342,623 Subsaturated transdermal therapeutic system having improved release characteristics 26 1993
5,411,740 Transdermal administration of oxybutynin 30 1994
5,635,203 Transdermal device having decreased delamination 23 1994
5,591,454 Method for lowering blood glucose 12 1995
5,674,895 Dosage form comprising oxybutynin 29 1995
5,840,754 Dosage form comprising oxybutynin 22 1996
5,912,268 Dosage form and method for treating incontinence 23 1997
6,919,373 Methods and devices for providing prolonged drug therapy 32 1999
6,262,115 Method for the management of incontinence 9 1999
6,919,092 Method for the management of incontinence 2 2001
6,930,129 Methods and devices for providing prolonged drug therapy 7 2001
 
KNOPP NEUROSCIENCES, INC. (5)
2007/0259,930 COMPOSITIONS AND METHODS OF USING R(+) PRAMIPEXOLE 2 2007
2008/0014,259 Compositions of R(+) and S(-) Pramipexole and Methods of Using the Same 2 2007
2009/0042,956 COMPOSITIONS AND METHODS OF USING (R)-PRAMIPEXOLE 2 2007
2008/0227,985 SYNTHESIS OF CHIRALLY PURIFIED SUBSTITUTED BENZOTHIAZOLES 2 2008
2009/0054,504 Modified Release Formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and Methods of Using the Same 3 2008
 
BOEHRINGER INGELHEIM INTERNATIONAL GMBH (4)
4,731,374 Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals 15 1985
4,886,812 Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals 19 1988
2006/0051,419 Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof 5 2005
2006/0110,450 Bilayer tablet of telmisartan and amlodipine 2 2005
 
Boehringer Ingelheim KG (4)
4,843,086 Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals 15 1987
5,112,842 Transdermal administration of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole 17 1990
5,650,420 Pramipexole as a neuroprotective agent 8 1994
6,156,777 Use of pramipexole as a neuroprotective agent 5 1999
 
CHEMAGIS LTD. (2)
2006/0069,263 Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole 2 2005
2006/0148,866 Novel process for preparing pramipexole and its optical isomeric mixture by reduction with sodium triacetoxyborohydride 2 2005
 
COLLEGIUM PHARMACEUTICAL, INC. (2)
2004/0132,826 Modified release compositions of milnacipran 12 2003
2004/0122,104 Modified release compositions of milnacipran 12 2003
 
GENERICS [UK] LIMITED (2)
2006/0106,224 Process for the preparation of 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiazoles from cyclohexanes and cyclohexanones as intermediates 4 2003
2008/0096,939 Process For Preparation Of Pramipexole By Chiral Chromatography 2 2005
 
POPULATION COUNCIL, INC., THE (2)
5,122,382 Transdermal contraceptive formulations, methods and devices 26 1990
5,314,694 Transdermal formulations, methods and devices 56 1993
 
UNIVERSITY OF VIRGINIA (2)
2006/0281,797 Neurorestoration with R(+) Pramipexole 2 2006
2007/0105,918 Use of Pramipexole to Treat Amyotrophic Lateral Sclerosis 2 2006
 
ACRUX DDS PTY LTD. (1)
6,929,801 Transdermal delivery of antiparkinson agents 25 2003
 
ADVANCED COCHLEAR SYSTEMS, INC. (1)
6,480,820 Method of processing auditory data 18 1999
 
AKORN, INC. (1)
6,443,976 Methods for treating conditions and illnesses associated with abnormal vasculature 24 1999
 
ALBEMARLE CORPORATION (1)
5,442,117 Enantiomeric resolution 6 1993
 
AMBO INNOVATIONS LLC (1)
2005/0053,649 Medication delivery device 4 2004
 
Boehringer Ingelheim GmbH (1)
4,201,211 Therapeutic system for administering clonidine transdermally 126 1977
 
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (1)
2005/0089,575 Bilayer pharmaceutical tablet comprising telmisartan and a diuretic and preparation thereof 2 2004
 
BRISTOL-MYERS SQUIBB COMPANY (1)
2005/0074,865 Adzymes and uses thereof 3 2004
 
BRISTOL-MYERS SQUIBB PHARMA COMPANY (1)
4,626,539 Trandermal delivery of opioids 67 1985
 
CYPRESS BIOSCIENCE, INC. (1)
2003/0203,055 Methods of treating visceral pain syndromes 31 2003
 
ELAN PHARMA INTERNATIONAL LIMITED (1)
6,541,486 Bis-benzimidazole compounds and analogs thereof for inhibiting cell death 3 2000
 
GLAXO GROUP LIMITED (1)
2006/0099,257 Controlled drug delivery systems providing variable release rates 7 2002
 
Human Genome Sciences, Inc. (1)
2002/0106,731 Bcl-2-like polynucleotides, polypeptides, and antibodies 7 2001
 
INTEL CORPORATION (1)
2005/0265,379 Multiple channel flow control with first-in-first-out (FIFO) read/write random access memory (RAM) 4 2004
 
INTELLIPHARMACEUTICS CORP. (1)
2004/0265,370 Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors 3 2004
 
IRONWOOD PHARMACEUTICALS, INC. (1)
2007/0203,209 Useful indole compounds 10 2006
 
J.B. CHEMICAL & PHARMACEUTICALS (1)
2006/0141,037 Bilayer tablets of oxcarbazepine for controlled delivery and a process of preparation thereof 4 2005
 
KNOLL AKTIENGESELLSCHAFT (1)
6,187,802 Substituted 4-arylmethylene-2-imino-2,3-dihydrothiazoles and derivatives and their pharmaceutical use 8 1999
 
L. PERRIGO COMPANY (1)
5,804,215 Transdermal patch disposal system and method 4 1997
 
LTS LOHMANN THERAPIE-SYSTEME AG (1)
2008/0026,043 Transdermal Therapeutic System Comprising an Adhesive Layer Method for Siliconizing the Back Layer or the System and Use of Said Back Layer 2 2005
 
NITTO DENKO CORPORATION (1)
5,830,497 Medicated plaster containing basic physiologically active agents and/or salts thereof 25 1996
 
ONO PHARMACEUTICAL CO., LTD. (1)
2009/0149,518 PHARMACEUTICAL FOR PROTECTION OF MOTOR NERVE IN PATIENT WITH AMYOTROPHIC LATERAL SCLEROSIS 2 2006
 
ORTHO-MCNEIL PHARMACEUTICAL, INC. (1)
5,069,909 Transdermal administration of buprenorphine 55 1990
 
PFIZER INC. (1)
2005/0226,926 Sustained-release tablet composition of pramipexole 5 2003
 
PHARMETRIX, OF MENLO PARK (1)
4,943,435 Prolonged activity nicotine patch 94 1988
 
PURDUE PHARMA L.P. (1)
2008/0020,028 TRANSDERMAL DOSAGE FORM COMPRISING AN ACTIVE AGENT AND A SALT AND A FREE-BASE FORM OF AN ADVERSE AGENT 12 2007
 
RUTGERS, STATE UNIVERSITY OF NEW JERSEY, THE, OLD QUEEN BUILDING, SOMERSET AND GEORGE STREETS, NEW BRUNSWICK, NJ 08903 (1)
4,806,341 Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration 72 1986
 
SHIRE LLC (1)
2004/0219,213 Oral pulsed dose drug delivery system 2 2004
 
State of Illinois, Department of Transportation (1)
4,395,859 Method and apparatus for securing an object to a support structure 6 1980
 
SYNTHON IP INC. (1)
6,727,367 Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor 7 2001
 
THE GENERAL HOSPITAL CORPORATION (1)
6,750,235 Pramipexole as a treatment for cocaine craving 2 2002
 
TITAN PHARMACEUTICALS, INC. (1)
2005/0031,667 Implantable polymeric device for sustained release of dopamine agonist 7 2004
 
WYETH (1)
2002/0177,626 Treatment of sleep disturbances 2 2002
 
Other [Check patent profile for assignment information] (3)
2005/0220,877 Bilayer tablet comprising an antihistamine and a decongestant 5 2004
2006/0286,167 Compositions and methods for the treatment of neurodegenerative diseases 4 2006
2008/0081,041 Method of Using IL6 Antagonists with Mitoxantrone for Prostate Cancer 3 2007

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