Prodrug of an ICE inhibitor
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United States of America Patent
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Sep 20, 2011
Grant Date -
Jan 8, 2009
app pub date -
Jul 1, 2008
filing date -
May 19, 2000
priority date (Note) -
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Abstract
This invention describes an ICE inhibitor prodrug (I) having good bioavailability.Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis, septic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis, asthma, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure, Huntington's disease, atherosclerosis, atopic dermatitis, leukemias and related disorders, myelodysplastic syndrome, uveitis or multiple myeloma.
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